β-catenin activation through mutation is rare in rectal cancer

Cancer Genetics and Cytogenetics

Volumn 128, Issue 1, 2001, Pages 43-45

  Nilbert, Mef ^a   Rambech, Eva ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA CATENIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TCF4; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CYTOGENETICS; EXON; FEMALE; GENE ACTIVATION; GENE MUTATION; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROTEIN DOMAIN; RECTUM CARCINOMA;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; BETA CATENIN; CHROMOSOME ABERRATIONS; CYTOSKELETAL PROTEINS; DNA PRIMERS; FEMALE; FRAMESHIFT MUTATION; GENES, APC; HUMANS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; RECTAL NEOPLASMS; TCF TRANSCRIPTION FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0035397694     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-4608(01)00397-1     Document Type: Article

References (15)

1. Association of the APC gene produce with β-catenin
2. Association of the APC tumor suppressor protein with catenins
3. Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly
4. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC -/- colon carcinoma
5. Functional interaction of β-catenin with the transcription factor LEF-1
6. Activation of β-catenin-Tcf signalling in colon cancer by mutations in β-catenin or APC
7. Mutations in β-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors
8. Activation of the β-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations
9. β-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway
10. Frequent mutation of β-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer
11. β-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas
12. Microsatellite instability is rare in rectal carcinomas and signifies hereditary cancer
13. Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability
14. Novel germline APC mutations in Swedish patients with familial adenomatous polyposis (FAP) and Gardner syndrome
15. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling