Translocation breakpoints in FHIT and FRA3B in both homologs of chromosome 3 in an esophageal adenocarcinoma

Genes Chromosomes and Cancer

Volumn 30, Issue 3, 2001, Pages 292-298

  Fang, Jianming M ^a   Arlt, Martin F ^a   Burgess, Ann C ^b   Dagenais, Susan L ^b   Beer, David G ^a,b   Glover, Thomas W ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GENE PRODUCT; PROTEIN FHIT; PROTEIN FRA3B; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CHIMERA; CHROMOSOME BREAKAGE; CHROMOSOME FRAGILE SITE; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION 3; ESOPHAGUS CARCINOMA; HUMAN; HUMAN CELL; MOLECULAR CLONING; PRIORITY JOURNAL;

ACID ANHYDRIDE HYDROLASES; ADENOCARCINOMA; AMINO ACID SEQUENCE; BASE SEQUENCE; CHROMOSOME BREAKAGE; CHROMOSOME FRAGILE SITES; CHROMOSOME FRAGILITY; CHROMOSOMES, HUMAN, PAIR 16; CHROMOSOMES, HUMAN, PAIR 3; CHROMOSOMES, HUMAN, PAIR 4; ESOPHAGEAL NEOPLASMS; HUMANS; MALE; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PROTEINS; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSLOCATION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0035154338     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2264(2000)9999:9999<::AID-GCC1095>3.0.CO;2-F     Document Type: Article

References (25)

1. Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells
2. Hereditary renal-cell carcinoma associated with a chromosomal translocation
3. Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons
4. The canine copper toxicosis locus is not syntenic with ATP7B or ATX1 and maps to a region showing homology to human 2p21
5. Changing patterns in the incidence of esophageal and gastric carcinoma
6. The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8
7. Expression of reciprocal hybrid transcripts of HMGIC and FHIT in a pleomorphic adenoma of the parotid gland
8. Instability at chromosomal fragile sites
9. Induction of sister chromatid exchanges at common fragile sites
10. Chromosome breakage and recombination at fragile sites
11. DNA polymerase α inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes
12. Cancer chromosome breakpoints and common fragile sites induced by aphidicolin
13. Frequent deletions within FRA7G at 7q31.2 in invasive epithelial ovarian cancer
14. Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest
15. Heritable fragile sites and cancer
16. Chromosomal fragile site FRA16D and DNA instability in cancer
17. Frequent deletions of FHIT and FRA3B in Barrett's metaplasia and esophageal adenocarcinomas
18. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
19. A 700-kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D
20. Preferential integration of marker DNA into the chromosomal fragile site at 3p14: An approach to cloning fragile sites
21. Viral integration and fragile sites in human papillomavirus-immortalized human keratinocyte cell lines
22. FHIT in human cancer
23. Aphidicolin-induced FRA3B break-points cluster in two distinct regions
24. Multicolor FISH mapping of YAC clones in 3p14 and identification of a YAC spanning both FRA3B and the t(3;8) associated with hereditary renal cell carcinoma
25. Constitutive fragile sites and cancer