Effect of dietary deoxycholic acid and cholesterol on fecal steroid concentration and its impact on the colonic crypt cell proliferation in azoxymethane-treated rats

Cancer Letters

Volumn 124, Issue 1, 1998, Pages 79-84

  Hori, Tetsuji ^a   Matsumoto, Keisuke ^a   Sakaitani, Yukiko ^a   Sato, Mikiko ^a   Morotomi, Masami ^a  

^a YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

Author keywords

Azoxymethane; Bile acid; Cholesterol; Crypt cell proliferation; Rat colon

Indexed keywords

AZOXYMETHANE; BILE ACID; CARCINOGEN; CHOLESTEROL; DEOXYCHOLIC ACID; STEROID; VINCRISTINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; COLON CARCINOGENESIS; COLON MUCOSA; CONTROLLED STUDY; FECES LEVEL; INTESTINE CRYPT; LIPID DIET; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; AZOXYMETHANE; BILE ACIDS AND SALTS; BODY WEIGHT; CARCINOGENS; CELL DIVISION; CHOLESTEROL, DIETARY; COCARCINOGENESIS; COLON; COLONIC NEOPLASMS; DEOXYCHOLIC ACID; EATING; FECES; MALE; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344; STEROIDS;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0032512880     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(97)00452-7     Document Type: Article

References (12)

1. J.H. Weisburger, E.L. Wynder, Etiology of colorectal cancer with emphasis on mechanism of action and prevention, in: V.T. De Vita, S. Hellman, S.A. Rosenberg (Eds.), Important Advances in Oncology, J.B. Lippincott, Philadelphia, PA, 1987, pp. 197-220.
2. Bruce W.R. Recent hypotheses for the origin of colon cancer. Cancer Res. 47:1987;4237-4242.
3. Lipkin M. Biomarkers of increased susceptibility to gastrointestinal cancer: new application to studies of cancer prevention in human subjects. Cancer Res. 48:1988;235-245.
4. Lapré J.A., Van der Meer R. Diet-induced increase of colonic bile acids stimulates lytic activity of fecal water and proliferation of colonic cells. Carcinogenesis. 13:1992;41-44.
5. Rao A.V., Friday D., Janezic S.A., Kendall C.W. Influence of dietary cholesterol on faecal steroid excretion and its impact on the colonic epithelium in mice: implications for colon carcinogenesis. Nutr. Res. 13:1993;45-57.
6. Corpet D.E., Taché S., Peiffer G. Colon tumor promotion: is it a selection process? Effects of cholate, phytate, and food restriction in rats on proliferation and apoptosis in normal and aberrant crypts. Cancer Lett. 114:1997;135-138.
7. Takahashi T., Morotomi M. Absence of cholic acid 7α-dehydroxylase activity in the strains of Lactobacillus and Bifidobacterium. J. Dairy Sci. 77:1994;3275-3286.
8. Morotomi M., Sakaitani Y., Satou M., Takahashi T., Takagi A., Onoue M. Effects of a high-fat diet on azoxymethane-induced aberrant crypt foci and fecal biochemistry and microbial activity in rats. Nutr. Cancer. 27:1997;84-91.
9. Van Faassen A., Bol J., Van Dokkum W., Pikaar N.A., Ockhuizen T.et al. Bile acids, neutral steroids, and bacteria in feces as affected by a mixed, a lacto-ovovegetarian, and a vegan diet. Am. J. Clin. Nutr. 46:1987;962-967.
10. Kelloff G.J., Boone C.W., Steele V.E., Crowell J.A., Lubet R., Sigman C.C. Progress in cancer chemoprevention: perspectives on agent selection and short-term clinical intervention trials. Cancer Res. 54(Suppl.):1994;2015s-2024s.
11. Sohn O.S., Ishizaki H., Yang C.S., Fiala E.S. Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450 II E1. Carcinogenesis. 12:1991;127-131.
12. Pretlow T.P., O'Riordan M.A., Somich G.A., Amini S.B., Pretlow T.G. Aberrant crypts correlate with tumor incidence in F344 rats treated with azoxymethane and phytate. Carcinogenesis. 13:1992;1509-1512.