A novel myeloid-restricted zebrafish CCAAT/enhancer-binding protein with a potent transcriptional activation domain

Blood

Volumn 97, Issue 9, 2001, Pages 2611-2617

  Lyons, Susan E ^a,b   Shue, Bixiong C ^a,b   Oates, Andrew C ^a,b   Zon, Leonard I ^a,b   Paul Liu, P ^a,b  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; CHIMERIC PROTEIN; DNA; RNA; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BONE MARROW CELL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; DNA BINDING; DNA SEQUENCE; ELECTROPHORETIC MOBILITY; EMBRYO; GENE; GENE EXPRESSION; GENE MAPPING; HEMATOPOIESIS; IN SITU HYBRIDIZATION; MOUSE; MYELOPOIESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TRANSCRIPTION INITIATION; ZEBRA FISH;

EID: 0035353205     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.9.2611     Document Type: Article

References (46)

1. Shivdasani RA, Orkin SH. The transcriptional control of hematopoiesis. Blood. 1996;87:4025-4039.
2. Yamanaka R, Lekstrom-Himes J, Barlow C, Wynshaw-Boris A, Xanthopoulos KG. CCAAT/enhancer binding proteins are critical components of the transcriptional regulation of hematopoiesis [Review]. Int J Mol Med. 1998;1:213-221.
3. Wedel A, Ziegler-Heitbrock HW. The C/EBP family of transcription factors. Immunobiology. 1995;193:171-185.
4. Lekstrom-Himes J, Xanthopoulos KG. Biological role of the CCAAT/enhancer-binding protein family of transcription factors. J Biol Chem. 1998;273:28545-28548.
5. Landschulz WH, Johnson PF, McKnight SL. The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science. 1988;240:1759-1764.
6. Wang ND, Finegold MJ, Bradley A, et al. Impaired energy homeostasis in C/EBP alpha knockout mice. Science. 1995;269:1108-1112.
7. Flodby P, Barlow C, Kylefjord H, Ahrlund-Richter L, Xanthopoulos KG. Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha. J Biol Chem. 1996;271:24753-24760.
8. Zhang DE, Zhang P, Wang ND, Hetherington CJ, Darlington GJ, Tenen DG. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc Natl Acad Sci U S A. 1997;94:569-574.
9. Radomska HS, Huettner CS, Zhang P, Cheng T, Scadden DT, Tenen DG. CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol Cell Biol. 1998;18:4301-4314.
10. Tanaka T, Akira S, Yoshida K, et al. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell. 1995;80:353-361.
11. Screpanti I, Romani L, Musiani P, et al. Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice. EMBO J. 1995;14:1932-1941.
12. Chumakov AM, Grillier I, Chumakova E, Chih D, Slater J, Koeffler HP. Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor. Mol Cell Biol. 1997;17:1375-1386.
13. Morosetti R, Park DJ, Chumakov AM, et al. A novel, myeloid transcription factor, C/EBP epsilon, is upregulated during granulocytic, but not monocytic, differentiation. Blood. 1997;90:2591-2600.
14. Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG. A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus. Genomics. 1996;35:30-38.
15. Yamanaka R, Barlow C, Lekstrom-Himes J, et al. Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice. Proc Natl Acad Sci U S A. 1997;94:13187-13192.
16. Paw BH, Zon LI. Zebrafish: a genetic approach in studying hematopoiesis. Curr Opin Hematol. 2000;7:79-84.
17. Herbomel P, Thisse B, Thisse C. Ontogeny and behaviour of early macrophages in the zebrafish embryo. Development. 1999;126:3735-3745.
18. Ransom DG, Haffter P, Odenthal J, et al. Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development. 1996;123:311-319.
19. Weinstein BM, Schier AF, Abdelilah S, et al. Hematopoietic mutations in the zebrafish. Development. 1996;123:303-309.
20. Willett CE, Cortes A, Zuasti A, Zapata AG. Early hematopoiesis and developing lymphoid organs in the zebrafish. Dev Dyn. 1999;214:323-336.
21. Jagadeeswaran P, Sheehan JP, Craig FE, Troyer D. Identification and characterization of zebrafish thrombocytes. Br J Haematol. 1999;107:731-738.
22. Stainier DY, Weinstein BM, Detrich HW 3rd, Zon LI, Fishman MC. Cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages. Development. 1995;121:3141-3150.
23. Liao W, Bisgrove BW, Sawyer H, et al. The zebrafish gene cloche acts upstream of a fik-1 homologue to regulate endothelial cell differentiation. Development. 1997;124:381-389.
24. Liao EC, Paw BH, Oates AC, Pratt SJ, Postlethwait JH, Zon LI. SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. Genes Dev. 1998;12:621-626.
25. Blake T, Adya N, Kim C, et al. Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. Blood. 2000;96:4178-4184.
26. Kwok C, Korn RM, Davis ME, et al. Characterization of whole genome radiation hybrid mapping resources for non-mammalian vertebrates. Nucleic Acids Res. 1998;26:3562-3566.
27. Geisler R, Rauch GJ, Baler H, et al. A radiation hybrid map of the zebrafish genome. Nat Genet. 1999;23:86-89.
28. Westerfield M. The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish (Danio rerio). 3rd ed. Eugene, OR: University of Oregon Press, 1995.
29. Riley BB, Grunwald DJ. Efficient induction of point mutations allowing recovery of specific locus mutations in zebrafish. Proc Natl Acad Sci U S A. 1995;92:5997-6001.
30. Kimmel CB, Kane DA, Walker C, Warga RM, Rothman MB. A mutation that changes cell movement and cell fate in the zebrafish embryo. Nature. 1989;337:358-362.
31. Yamanaka R, Kim GD, Radomska HS, et al. CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing. Proc Natl Acad Sci U S A. 1997;94:6462-6467.
32. Kozak M. Structural features in eukaryotic mRNAs that modulate the initiation of translation. J Biol Chem. 1991;266:19867-19870.
33. Ho RK, Kane DA. Cell-autonomous action of zebrafish spt-1 mutation in specific mesodermal precursors. Nature. 1990;348:728-730.
34. Thompson MA, Ransom DG, Pratt SJ, et al. The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis. Dev Biol. 1998;197:248-269.
35. Lieschke GJ, Oates AC, Paw BH, Ho RK, Zon LI, Layton JE. Anatomical and genetic separation of early myeloid and erythroid lineage hematopoietic commitment in the zebrafish embryo [abstract]. Cold Spring Harbor, NY: Zebrafish Development and Genetics-Cold Spring Harbor Laboratory; 2000:309.
36. Williamson EA, Xu HN, Gombart AF, et al. Identification of transcriptional activation and repression domains in human CCAAT/enhancer-binding protein epsilon. J Biol Chem. 1998;273:14796-14804.
37. Postlethwait J, Amores A, Force A, Yan YL. The zebrafish genome. Methods Cell Biol. 1999;60:149-163.
38. Amores A, Force A, Yan YL, et al. Zebrafish hox clusters and vertebrate genome evolution. Science. 1998;282:1711-1714.
39. Trede NS, Zon LI. Development of T-cells during fish embryogenesis. Dev Comp Immunol. 1998;22:253-263.
40. Lin H, Freedman M, Zhou Y, Zon L, Handin RI. Thrombocyte development in the zebrafish (Danio redo) [abstract]. Blood. 2000;96:36a.
41. Takiguchi M. The C/EBP family of transcription factors in the liver and other organs. Int J Exp Pathol. 1998;79:369-391.
42. Nerlov C, Ziff EB. Three levels of functional interaction determine the activity of CCAAT/enhancer binding protein-alpha on the serum albumin promoter. Genes Dev. 1994;8:350-362.
43. Pei DQ, Shih CH. An "attenuator domain" is sandwiched by two distinct transactivation domains in the transcription factor C/EBP. Mol Cell Biol. 1991;11:1480-1487.
44. Trautwein C, Walker DL, Plumpe J, Manns MP. Transactivation of LAP/NF-IL6 is mediated by an acidic domain in the N-terminal part of the protein. J Biol Chem. 1995;270:15130-15136.
45. Verbeek W, Gombart AF, Chumakov AM, Muller C, Friedman AD, Koeffler HP. C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters. Blood. 1999;93:3327-3337.
46. Oelgeschlager M, Nuchprayoon I, Luscher B, Friedman AD. C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter. Mol Cell Biol. 1996;16:4717-4725.