Production of 1α,25-Dihydroxy-3-epi-vitamin D3 in two rat osteosarcoma cell lines (UMR 106 and ROS 17/2.8): Existence of the C-3 epimerization pathway in ROS 17/2.8 cells in which the C-24 oxidation pathway is not expressed

Bone

Volumn 24, Issue 5, 1999, Pages 457-463

  Siu Caldera, M L ^a   Sekimoto, H ^a   Weiskopf, A ^b   Vouros, P ^b   Muralidharan, K R ^c   Okamura, W H ^c   Bishop, J ^c   Norman, A W ^c   Uskokovic M R ^d   Schuster, I ^e   Reddy, G S ^a  

^a BROWN UNIVERSITY   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d HOFFMANN LA ROCHE INC   (United States)

^e NOVARTIS RESEARCH INSTITUTE   (Austria)

Author keywords

1 ,25(OH)2 3 epi D3; 1 ,25(OH)2D3; C 24 oxidation pathway; C 3 epimerization pathway; Metabolism; Osteosarcoma cells

Indexed keywords

CALCITRIOL;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MASS SPECTROMETRY; NONHUMAN; OSTEOSARCOMA CELL; OXIDATION; RAT; VITAMIN D METABOLISM; ANIMAL; BIOSYNTHESIS; BONE TUMOR; CELL CULTURE; CYTOLOGY; KIDNEY; MALE; MASS FRAGMENTOGRAPHY; METABOLISM; OSTEOSARCOMA; OXIDATION REDUCTION REACTION; PERFUSION; SPRAGUE DAWLEY RAT; STEREOISOMERISM;

ANIMALS; BONE NEOPLASMS; CALCITRIOL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; KIDNEY; MALE; OSTEOSARCOMA; OXIDATION-REDUCTION; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; TUMOR CELLS, CULTURED;

EID: 0032587861     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(99)00019-8     Document Type: Article

References (48)

1. 3 is regulated by parathyroid hormone in UMR106 osteoblastic cells. Endocrinology. 139:1998;3375-3381.
2. 3 metabolite in primary human keratinocytes, upregulates and undergoes side chain oxidation. Norman A.W., Bouillon R., Thomasset M. Vitamin D chemistry, biology and clinical applications of the steroid hormone. 1997;579-580 University of California, Riverside, CA.
3. 3 rapidly increases cytosolic calcium in clonal rat osteosarcoma cells lacking the vitamin D receptor. J Bone Miner Res. 6:1991;1269-1275.
4. 3 production by human keratinocytes. J Clin Invest. 78:1986;557-566.
5. Bischof M.G., Siu-Caldera M.-L., Weiskopf A., Vouros P., Cross H.S., Peterlik M., Reddy G.S. Differentiation-related pathways of 1α,25-dihydroxycholecalciferol metabolism in human colon adenocarcinoma-derived Caco-2 cells Production of 1α,25-dihydroxy-3epi-cholecalciferol . Exp Cell Res. 241:1998;194-201.
6. Bouillon R., Okamura W.H., Norman A.W. Structure-function relationships in the vitamin D endocrine system. Endocr Rev. 16:1995;200-257.
7. 3, is a potent suppressor of parathyroid hormone secretion. J Cell Biochem. 73:1999;106-113.
8. DeLuca H.F. The metabolism and functions of vitamin D. Adv Exp Med Biol. 196:1986;361-375.
9. Garabedian M., Lieberherr M., N'Guyen T.M., Corvol M.T., Bailly Du Bois M., Balsan S. The in vitro production and activity of 24,25-dihydroxycholecalciferol in cartilage and calvarium. Clin Orthop Rel Res. 135:1978;241-248.
10. 3. J Biol Chem. 256:1981;7738-7740.
11. 3-26,23-lactone. J Biol Chem. 262:1987;7165-7170.
12. 3 and its physiological implications. Steroids. 49:1987;29-53.
13. 3-24-hydroxylase by aminophylline A cytochrome P-450 monooxygenase system . Biochem Biophys Res Commun. 90:1979;50-57.
14. 3. Physiol Rev. 64:1984;478-504.
15. Liel Y., Kraus S., Levy J., Shany S. Evidence that estrogens modulate activity and increase the number of 1,25-dihydroxyvitamin D receptors in osteoblast-like cells (ROS 17/2.8). Endocrinology. 130:1992;2597-2601.
16. 3 in osteosarcoma cell line UMR-106. J Biol Chem. 262:1987;14394-14401.
17. 3 in target cells. J Nutr Sci Vitaminol (Special Issue):75-78; 1992.
18. 3 to calcitroic acid. Biochem J. 262:1989;173-180.
19. 3 in target cells. Norman A.W., Bouillon R., Thomasset M. Vitamin D chemistry, biology and clinical applications of the steroid hormone. 1997;159-160 University of California, Riverside, CA.
20. 3. J Biol Chem. 258:1983;13458-13465.
21. 3 metabolism in a human osteosarcoma cell line and human bone cells. J Bone Miner Res. 5:1990;597-608.
22. 3 in seven human prostatic carcinoma cell lines. Clin Cancer Res. 1:1995;997-1003.
23. 3. J Biol Chem. 272:1997;14115-14119.
24. 3. J Org Chem. 58:1993;1895-1899.
25. 3 . Biochemistry. 22:1983;5848-5853.
26. Napoli J.L., Martin C.A., Horst R.L. Induction, inhibition, and analysis of vitamin D metabolism in cultured cells. Methods Enzymol. 123:1986;491-501.
27. 3, a steroid hormone that produces biologic effects via both genomic and nongenomic pathways. J Steroid Biochem Mol Biol. 41:1992;231-240.
28. 3. J Biol Chem. 268:1993;20022-20030.
29. 3 function as ligands for the D-binding protein, nuclear receptor and membrane receptor A status report . J Steroid Biochem Mol Biol. 56:1996;13-22.
30. 3 enriched in cloned osteoblast-like rat osteogenic sarcoma cells. FEBS Lett. 115:1980;139-142.
31. 3 receptors Structure and function in transcription . Annu Rev Nutr. 11:1991;189-216.
32. Pols H.A., Schilte H.P., Nijweide P.J., Visser T.J., Birkenhager J.C. The influence of albumin on vitamin D metabolism in fetal chick osteoblast-like cells. Biochem Biophys Res Commun. 125:1984;265-272.
33. 3-1-hydroxylase by chronic metabolic acidosis. Am J Physiol. 243:1982;E265-E271.
34. 3 produced in rat kidney. Biochemistry. 26:1987;324-331.
35. 3 through C-24 oxidation pathway. Biochemistry. 28:1989;1763-1769.
36. 3 in neonatal human keratinocytes. Norman A.W., Bouillon R., Thomasset M. Vitamin D A pluripotent steroid hormone: Structural studies, molecular endocrinology and clinical applications . 1994;172-173 Walter de Gruyter, New York.
37. Reinhardt T.A., Horst R.L. Parathyroid hormone down-regulates 1,25-dihydroxyvitamin D receptors (VDR) and VDR messenger ribonucleic acid in vitro and blocks homologous up-regulation of VDR in vivo. Endocrinology. 127:1990;942-948.
38. 3. Pediatr Res. 34:1993;98-104.
39. Schuster I., Astecker N., Egger H., Herzig G., Reddy G.S., Schmid J., Vorisek G. Vitamin D-metabolism in human keratinocytes and biological role of products. Norman A.W., Bouillon R., Thomasset M. Vitamin D chemistry, biology and clinical applications of the steroid hormone. 1997;551-558 University of California, Riverside, CA.
40. 3 by growth zone and resting zone chondrocytes is dependent on cell maturation and is regulated by hormones and growth factors. Endocrinology. 130:1992;2495-2504.
41. 3 into their respective lactones. Endocrinology. 136:1995;4195-4203.
42. 3 in rat osteosarcoma cells (UMR 106 and ROS 17/2.8) and rat vascular smooth muscle cells. J Bone Miner Res. 23:(Suppl):1998;S426.
43. 3-24-hydroxylase. Arch Biochem Biophys. 171:1975;521-526.
44. 3 Isolation, identification, and biological activity . Arch Biochem Biophys. 210:1981;104-109.
45. 3-24-hydroxylase activity in Caco-2 cells An in vitro model of intestinal vitamin D catabolism . Endocrinology. 126:1990;2868-2875.
46. 3. Biochemistry. 22:1983;1073-1076.
47. 3 in vitro synthesis by human decidua and placenta. Nature. 281:1979;317-319.
48. 3 (analogs) by cytochrome P450 enzyme inhibitors is compound- and cell-type specific. J Steroid Biochem Mol Biol. 57:1996;197-202.