Vitamin B12-mediated uptake of erythropoietin and granulocyte colony stimulating factor in vitro and in vivo

International Journal of Pharmaceutics

Volumn 145, Issue 1-2, 1996, Pages 1-8

  Habberfield, Alan ^a   Jensen Pippo, Kathleen ^a   Ralph, Lloyd ^a   Westwood, Steven W ^b   Russell Jones, Gregory J ^b  

^a AMGEN INC   (United States)

^b Biotechnology Australia   (Australia)

Author keywords

Cobalamin; Erythropoietin; G CSF; Oral

Indexed keywords

CYANOCOBALAMIN; RECOMBINANT ERYTHROPOIETIN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG MIXTURE; DRUG UPTAKE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE EPITHELIUM CELL; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0030573059     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(96)04690-X     Document Type: Article

References (18)

1. Cotes, P.M. and Bangham, D.R., Bio-assay of erythropoeitin in mice made polycythaemic by exposure to air at a reduced pressure. Nature, 4793 (1961) 1065-1067.
2. Dan, N. and Cutler, D,F., Transcytosis and processing of intrinsic factor-cobalamin in Caco-2 cells. J. Biol. Chem., 269 (1994) 18849-18855.
3. 12 through polarized monolayers of Caco-2 cells. Gastroenterology, 88 (1990) 1272-1279.
4. Egrie, J.C., Strickland, T.W., Lane, J., Aoki, K., Cohen, A.M., Smalling, R., Trail, G., Lin, F.K., Browne, J.K. and Hines, D.K., Characterization and biological effects of recombinant human erythropoietin. Immunobiology, 172 (1986) 213-224.
5. Hidalgo, I.J., Raub, T.J and Borchardt, R.T., Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability, Gastroenterology, 96 (1989) 736-749.
6. Jensen-Pippo, K.E., Whitcomb, K.L., DePrince, R.B., Ralph, L. and Habberfield, A.D., Enteral bioavailability of human granulocyte colony stimulating factor conjugated with poly(ethytene glycol). Pharm. Res., 13 (1996) 102-107.
7. Krantz, S.B. and Goldwasser, E., Specific binding of erythropoietin to spleen cells infected with the anaemia strain of Friend virus. Proc. Natl. Acad. Sci. USA, 81 (1984) 7574-7578.
8. Le Bivic, A., Quaroni, S., Nichols, B, and Rodriguez-Boulan, E., Biogenetic pathways of plasma membrane proteins in Caco-2, a human intestinal epithelial cell line. J. Cell Biol., 111 (1990) 1351-1361.
9. Levine, J.S., Nakane, P.K. and Allen, R.H., Immunocytochemical localisation of human intrinsic factor in: the non-stimulated stomach. Gastroenterology, 79 (1980) 493-502.
10. Marshall, K., in G.S. Banker and C.T. Rhodes (Eds.), Modern Pharmaceutics, 1979, p. 10, Marcel Dekker, New York.
11. Mathan, V.I., Babior, B.M. and Donaldson, R.M. Jr., Kinetics of the attachment of intrinsic factor-bound cobamides to ileal receptors. J. Clinical Invest., 54 (1974) 598-608.
12. Morstyn, G. and Burgess, A.W., Haematopoietic growth factors: a review. Cancer Res., 48 (1988) 5624-5637.
13. Rubas, W., Jezyk, N. and Grass, G.M., Comparison of the permeability characteristics of a human colonic epithelial (Caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption. Pharm. Res., 10 (1993) 113-118.
14. 12 mediated oral delivery systems for Granulocyte-Colony Stimulating Factor and erythropoietin. Bioconjugate Chemistry, 6 (1995) 459-465.
15. Seetharam, B., Presti, M., Frank, B., Tiruppathi, C. and Alpers, D.H., Intestinal uptake and release of cobalamin complexed with rat intrinsic factor. Am. J. Physiol., 248 (1985) G326-G331.
16. Smith, P.L., Wall, D.A., Gochocco, C.H. and Wilson, G., Routes of delivery: Case studies: Oral absorption of peptides and proteins. Adv. Drug Delivery Reviews, 8 (1992) 253-290.
17. Takada, K., Nakahigashi, Y.T.T., Kishimoto, S., Ushirogawa, Y. and Takaya, T., Pharmacological activity of tablets containing recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats. Int. J. Pharm., 101 (1994) 89-96.
18. Wilson, G., Hassan, I.F., Dix, C.J., Williamson, I., Shah, R., Mackay, M. and Artusson, P., Transport and permeability of human Caco-2 cells: An in vitro model of the intestinal epithelial cell barrier. J. Control. Rel., 11 (1990) 25-40.