Maturation versus death of developing double-positive thymocytes reflects competing effects on Bcl-2 expression and can be regulated by the intensity of CD28 costimulation

Journal of Immunology

Volumn 166, Issue 5, 2001, Pages 3468-3475

  McKean, D J ^a   Huntoon, C J ^a   Bell, M P ^a   Tai, X ^a   Sharrow, S ^a   Hedin, K E ^a   Conley, A ^a   Singer, A ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD2 ANTIGEN; CD28 ANTIGEN; CELL SURFACE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL MATURATION; CELL STIMULATION; FEMALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE;

EID: 0035284806     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.5.3468     Document Type: Article

References (49)

1. Selective events in T cell development
2. T cell tolerance by clonal elimination in the thymus
3. Another view of the selective model of thymic selection
4. Thymocyte development in major histocompatibility complex-deficient mice: Evidence for stochastic commitment to the CD4 and CD8 lineages
5. Evidence for a differential avidity model of T cell selection in the thymus
6. T cell receptor antagonist peptides induce positive selection
7. + thymocytes
8. Identity of cells that imprint H-2-restricted T-cell specificity in the thymus
9. Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals
10. + thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: Implications for negative selection in the thymus
11. + T cell activation
12. Identification and distribution of the costimulatory receptor CD28 in the mouse
13. Medullary thymic epithelium expresses a ligand for CTLA4 in situ and in vivo
14. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
15. Characterization of a monoclonal antibody which detects all mature αβ T cell receptors
16. Class II histocompatibility molecules associate with calnexin during assembly in the endoplasmic reticulum
17. + T cell lineages: A new perspective on thymic commitment and selection
18. Positive and negative selection invoke distinct signaling pathways
19. + thymocytes
20. ras distinguishes positive and negative selection in thymocytes
21. A synthetic inhibitor of the mitogen-activated protein kinase cascade
22. + stage, before the onset of functional maturation
23. A molecular map of T cell development
24. Membrane compartmentation is required for efficient T cell activation
25. Engagement of T cell receptor triggers its recruitment to low-density detergent insoluble membrane domains
26. T lymphocyte costimulation mediated by reorganization of membrane microdomains
27. Non-CD28 costimulatory molecules present in T cell rafts induce T cell costimulation by enhancing the association of TCR with rafts
28. Kinetic proofreading in T-cell receptor signal transduciton
29. Kinetic discrimination of T-cell activation
30. A TcR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists
31. k complexes: Correlation of the dissociation rate with T-cell responsiveness
32. CD28-mediated signaling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
33. Identification of a naturally occurring ligand for thymic positive selection
34. + T cells
35. T-cell receptor affinity and thymic positive selection
36. T cell positive selection by a high density, low affinity ligand
37. A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex
38. Thymic selection and autoreactivity are regulated by multiple coreceptors involved in T cell activation
39. Several different cell surface molecules control negative selection of medullary thymocytes
40. TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection
41. Fas modulation of apoptosis during negative selection of thymocytes
42. CD28 expression is not essential for positive and negative selection of thymocytes or pheripheral T cell tolerance
43. T cell stimulation: An abundance of B7s
44. T cell costimulatory molecules other than CD28
45. Bcl-xL and Bcl-2 repress a common pathway of cell death
46. Bclx regulates the survival of double-positive thymocytes
47. + stage during positive selection and promotes thymocyte differentiation at several control points
48. A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis
49. A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells