Clinical and immunological benefits from highly active antiretroviral therapy in spite of limited viral load reduction in HIV type 1 infection

AIDS Research and Human Retroviruses

Volumn 17, Issue 4, 2001, Pages 277-286

  Hejdeman, B ^a   Lenkei, R ^a   Leandersson, A C ^b   Hultstrom A L ^b   Wahren, B ^b   Sandstrom E ^a   Bratt, G ^a  

^a STOCKHOLM SÖDER HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD20 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CELL MARKER; INDINAVIR; LAMIVUDINE; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; VIRUS RNA;

ADULT; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CLINICAL OBSERVATION; FEMALE; FLOW CYTOMETRY; HELPER CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LEUKOCYTE COUNT; MALE; MEMORY CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TREATMENT OUTCOME; VIRUS LOAD;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; B-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOLOGIC MEMORY; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RNA, VIRAL; T-LYMPHOCYTE SUBSETS; TREATMENT OUTCOME; VIRAL LOAD;

EID: 0035282884     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/08892220150503654     Document Type: Article

References (26)

1. Changing patterns of mortality across Europe in patients infected with HIV-1
2. Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS
3. Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection
4. Determination of antibody binding capacity of lymphocyte membrane antigens by flow cytometry in 58 blood donors
5. Abnormalities of CD45 isoform expression in HIV infection
6. Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men
7. Increased losses of CD4+CD45RA+ cells in late stages of HIV infection is related to increased risk of death: Evidence from a cohort of 347 HIV-infected individuals
8. Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
9. High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors
10. CD8 naive T cell counts decrease progressively in HW-infected adults
11. Elevated levels of CD38+CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: Results of 6 years of follow-up
12. Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation
13. Performance of calibration standards for antigen quantitation with flow cytometry
14. A randomized double blind placebo controlled trial of therapeutic immunization with rgp160 in human immunodeficiency virus infection
15. Long-term immunotherapy in HIV infection, combined with short-term antiretroviral treatment
16. Immunological changes in human immunodeficiency virus (HIV)-infected individuals during HIV-specific protease inhibitor treatment
17. Highly active antiretroviral therapy during early HIV infection reverses T-cell activation and maturation abnormalities
18. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
19. Vigorous HIV-1 specific CD4+ T-cell responses associated with control of viremia
20. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation
21. Long-term evaluation of T-cell subsets and T-cell function after HAART in advanced stage HIV-1 disease
22. T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life
23. Lifespan of human lymphocyte subsets defined by CD45 isoforms
24. Expression of CD28 and CD38 by CD8+ T lymphocytes in HIV-1 infection correlates with markers of disease severity and changes towards normalization under treatment
25. CD8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: Development of HLA-DR+CD38-CD8+ cells is associated with subsequent stable CD4+ cell levels
26. Mega-HAART, resistance and scheduled treatment interruptions (STI)