Normal tissue radiobiology: From the laboratory to the clinic

International Journal of Radiation Oncology Biology Physics

Volumn 49, Issue 2, 2001, Pages 353-365

  Hill, R P ^a   Rodemann, H P ^b   Hendry, J H ^c   Roberts, S A ^c   Anscher, M S ^d  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c CHRISTIE HOSPITAL   (United Kingdom)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CYTOKINE; GROWTH FACTOR; RECEPTOR BLOCKING AGENT; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

CANCER RADIOTHERAPY; CONFERENCE PAPER; FIBROBLAST; FIBROSIS; PARENCHYMA; PRIORITY JOURNAL; RADIOSENSITIVITY; RADIOTHERAPY;

ANIMALS; ATAXIA TELANGIECTASIA; CELL DIFFERENTIATION; CELL SURVIVAL; CYTOKINES; DIFFUSION OF INNOVATION; DOSE FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; FIBROBLASTS; FIBROSIS; HUMANS; LINEAR MODELS; LUNG; MICE; MICE, SCID; MODELS, BIOLOGICAL; ORGAN SPECIFICITY; RADIATION INJURIES; RADIATION TOLERANCE; RADIOBIOLOGY; RATS; RELATIVE BIOLOGICAL EFFECTIVENESS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TREATMENT OUTCOME; UP-REGULATION;

EID: 0035253539     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(00)01484-X     Document Type: Conference Paper

References (115)

1. Clinical impact of predictive assays for acute and late radiation morbidity
2. Pharmacologic modification of radiation-induced late normal tissue injury
3. Failla Memorial Lecture. Contrarian concepts in the progress of radiotherapy
4. The relationship between functional assays of radiation response in the lung and target cell depletion
5. Microvasculature and radiation damage
6. Dose, time and fractionation; A clinical hypothesis
7. Assessment of chronic gamma radiosensitivity as an in vitro assay for heterozygote identification of ataxia-telangiectasia
8. A review of human cell radiosensitivity in vitro
9. The importance of genetics for the optimization of radiation therapy
10. The ESTRO Regaud lecture; Inherent radiosensitivity of tumor and normal tissue cells as a predictor of human tumor response
11. How much could the radiotherapy dose be altered for individual patients based on a predictive assay of normal-tissue radiosensitivity?
12. The modelled benefits of individualizing radiotherapy patients dose using cellular radiosensitivity assays with inherent variability
13. Low predictive value of intrinsic fibroblast radiosensitivity for fibrosis development following radiotherapy for breast cancer
14. Variability in the radiosensitivity of normal cells and tissues. Report from a workshop organised by the European Society for Therapeutic Radiology and Oncology in Edinburgh, UK, 19 September 1998
15. Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer
16. Differential radiosensitising effect of the scid mutation among tissues, studied using high and low dose rates; Implications for prognostic indicators in radiotherapy
17. Lack of correlation between residual radiation-induced DNA damage, in keratinocytes assayed directly from skin, and late radiotherapy reactions in breast cancer patients
18. The radiobiology of human tumour cells
19. Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation
20. LENT SOMA scales for all anatomic sites
21. Molecular biology mechanisms in the radiation induction of pulmonary injury syndromes; Interrelationship between the alveolar macrophage and the septal fibroblast
22. A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis
23. Intratracheal injection of adenovirus containing the human MnSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis
24. Manganese superoxide dismutase plasmid/liposome pulmonary radioprotective gene therapy; Modulation of irradiation-induced mRNA for IL-I, TNF-alpha, and TGF-beta correlates with delay of organizing alveolitis/fibrosis
25. Partial volume rat lung irradiation; An evaluation of early DNA damage
26. Spatial heterogeneity of the volume effect for radiation pneumonitis in mouse lung
27. Estimation of the spatial distribution of target cells for radiation pneumonitis in mouse lung
28. Evidence for two patterns of inheritance of sensitivity to induction of lung fibrosis in mice by radiation, one of which involves two genes
29. Murine susceptibility to radiation-induced pulmonary fibrosis is influenced by a genetic factor implicated in susceptibility to bleomycin-induced pulmonary fibrosis
30. Fibroblast radiosensitivity in vitro and lung fibrosis in vivo; Comparison between a fibrosis-prone and fibrosis-resistant mouse strain
31. Differences in correlation of mRNA gene expression in mice sensitive and resistant to radiation-induced pulmonary fibrosis
32. Immunohistochemical localization of transforming growth factor beta and tumor necrosis factor alpha in the lungs of fibrosis-prone and non-fibrosing mice during the latent period and early phase after irradiation
33. TGF-beta1 levels in pre-treatment plasma identify breast cancer patients at risk of developing post-radiotherapy fibrosis
34. Cellular sources of transforming growth factor-beta isoforms in early and chronic radiation enteropathy
35. Paradigm shifts in the radiation pathophysiology of late effects in normal tissues; Molecular vs. classic concepts
36. Effect of fibroblast implants on wound healing of irradiated skin; Assay of wound strength and quantitative immunohistology of collagen
37. Intradermal injection of autologous dermal fibroblasts improves wound healing in irradiated skin
38. Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatic transplantation
39. Evidence for circulating bone-marrow derived endothelial cells
40. Ischaemic and cytokine-induced mobilization of bone-marrow derived endothelial progenitor cells for neovascularization
41. Differential degradation of intracellular proteins in human skin fibroblasts of mitotic and mitomycin C-induced postmitotic differentiation states
42. Differentiation of fibroblast stem cells
43. Selective enrichment of and biochemical characterization of 7 human skin fibroblast cell types in vitro
44. TGF-β1-mediated alterations of rat lung fibroblast differentiation resulting in the radiation-induced fibrotic phenotype
45. Human skin fibroblasts in vitro differentiate along a terminal cell lineage
46. Cellular basis of radiation-induced fibrosis
47. Radiation-induced lung injury in vivo; Expression of transforming growth factor β precedes fibrosis
48. Expression of 72-kDa gelatinase, collagenase, and tissue metallo-proteinase inhibitor (TIMP) in primary pig skin fibroblast cultures derived from radiation-induced skin fibrosis
49. Negative regulator of the cell cycle
50. Radiation-induced fibrosis; Experimental studies
51. Radiation-induced differentiation of human skin fibroblasts; Relationship with cell survival and collagen production
52. Molecular and cellular basis of radiation fibrosis
53. Evidence for a positive correlation between in vitro radiosensitivity of normal human skin fibroblasts and the occurrence of subcutaneous fibrosis after radiotherapy
54. Differentiation state of skin fibroblast cultures versus risk of subcutaneous fibrosis after radiotherapy
55. Predictive assays in radiation therapy
56. Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer
57. Low does-rate fibroblast radiosensitivity and the prediction of patient response to radiotherapy
58. Normal tissue radiosensitivity in breast cancer patients
59. Cellular radiosensitivity and DNA damage in primary human fibroblasts
60. 60Co γ-irradiation in vitro
61. Dose fractionation and regeneration in radiotherapy for cancer of the oral cavity and oropharynx. Part 2. Normal tissue responses; Acute and late effects
62. The time factor for late reactions in radiotherapy; Repopulation or intracellular repair?
63. The time factor and repopulation in tumours and normal tissues
64. A modelled comparison of the effects of using different ways to compensate for missed treatment days in radiotherapy
65. The CHART regimen and morbidity
66. Repair capacity and kinetics of human skin during fractionated radiotherapy; Erythema, desquamation, and telangiectasia after 3 and 5 years' follow-up
67. Fractionation sensitivity and latency of telangiectasia after postmastectomy radiotherapy; a graded-response analysis
68. Relationship between early and late normal-tissue injury after postmastectomy radiotherapy
69. Response of human organs to single (or fractionated equivalent) doses of irradiation
70. The steepness of the dose response curve both for tumor cure and normal tissue injury
71. Late normal tissue sequelae from radiation therapy for carcinoma of the tonsil; Patterns of fractionation study of radiobiology
72. Can WR-2721 be improved upon?
73. The sulfhydryl containing compounds WR-2721 and glutathione as radio- and chemoprotective agents. A review, indications for use and prospects
74. Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma; Final analysis of a randomized trial of the EORTC cooperative group of radiotherapy
75. Treatment acceleration in radiotherapy; The relative time factors and dose-response slopes for tumours and normal tissues
76. The volume effect in radiotherapy-Its biological significance
77. Tolerance of normal tissue to therapeutic irradiation
78. Comparison of radiation side-effects of conformal and conventional radiotherapy in prostate cancer; A randomised trial
79. Acute toxicity in pelvic radiotherapy; a randomised trial of conformal versus conventional treatment
80. Optimization of stereotactically-guided conformal treatment planning of sellar and parasellar tumors, based on normal brain dose volume histograms
81. Amelioration of both early and late radiation-induced damage to pig skin by essential fatty acids
82. Influence of protein nutrition on dose-survival relationship following rat kidney irradiation
83. Influence of a low protein diet on radiation nephropathy in the pig
84. Experimental studies on the pathogenesis of the chronic radiation ulcer of the large bowel in rats
85. Potential clinical impact of normal-tissue intrinsic radiosensitivity testing
86. Plasma transforming growth factor beta1 as a predictor of radiation pneumonitis
87. Transforming growth factor-β1 expression in irradiated liver
88. Transforming growth factor beta-1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis
89. Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta
90. Transforming growth factor beta levels in rat wound chambers
91. Accelerated healing of incisional wounds in rats induced by transforming growth factor beta
92. Transforming growth factor type-beta; Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
93. Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo
94. The effect of transforming growth factor beta on cell proliferation and collagen formation by lung fibroblasts
95. TGFβ is a strong and fast-acting positive regulator of the level of Type 1 plasminogen activator inhibitor mRNA in WI-38 lung fibroblast
96. Hepatic toxicity resulting from cancer treatment
97. Pulmonary venoocclusive disease following marrow transplantation
98. Hepatic venoocclusive disease after bone marrow transplantation; Immunohistochemical identification of the material within occluded central venules
99. Alterations in pulmonary mRNA encoding procollagens, fibronectin, and transforming growth factor beta precede bleomycin-induced pulmonary fibrosis
100. Early increases in pulmonary mRNA encoding procollagens and transforming growth factor beta in mice sensitive to cyclophosphamide-induced pulmonary fibrosis
101. Effect of antibody to transforming growth factor β on bleomycin induced accumulation of lung collagen in mice
102. Regulation of transforming growth factor-β1 mRNA expression by taurine and niacin in the bleomycin hamster model of lung fibrosis
103. Treatment with anti-transforming growth factor β antibodies influences an altered pattern of cytokines gene expression in injured rat liver
104. Dietary omega-3 lipids delay the onset and progression of autoimmune lupus nephritis by inhibiting transforming growth factor β mRNA and protein expression
105. Angiotensin-converting enzyme inhibition attenuates proteinuria and renal TGF-β1 mRNA expression in rats with chronic renal disease
106. Effects of pirfenidone on transforming growth factor-β gene expression at the transcriptional level in bleomycin hamster model of fibrosis
107. TGF-β1 production in radiation nephropathy; Role of angiotensin II
108. Captopril preserves function and ultrastructure in experimental radiation nephropathy
109. Radiation pneumotoxicity in rats; modification by inhibitors of angiotensin converting enzyme
110. Can angiotensin converting enzyme inhibitors protect against symptomatic radiation pneumonitis?