Spinal and supraspinal changes in opioid mRNA expression are related to the onset of pain behaviors following excitotoxic spinal cord injury

Pain

Volumn 90, Issue 1-2, 2001, Pages 181-190

  Abraham, Karen E ^a   McGinty, Jacqueline F ^b   Brewer, Kori L ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Dynorphin; Enkephalin; Quisqualic acid; Spinal cord injury

Indexed keywords

DYNORPHIN; ENKEPHALIN; OPIATE PEPTIDE; QUISQUALIC ACID;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOMUTILATION; BITE; BRAIN CORTEX; BRAIN SLICE; CHRONIC PAIN; CONTROLLED STUDY; GENE EXPRESSION; GROOMING; IN SITU HYBRIDIZATION; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD INJURY; TEMPERATURE SENSITIVITY; THALAMUS;

ANIMALS; BRAIN; DYNORPHINS; ENKEPHALINS; EXCITATORY AMINO ACID AGONISTS; GENE EXPRESSION; GROOMING; MALE; OPIOID PEPTIDES; PAIN; PROTEIN PRECURSORS; QUISQUALIC ACID; RATS; RATS, LONG-EVANS; RNA, MESSENGER; SPINAL CORD; SPINAL CORD INJURIES;

EID: 0035252406     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(00)00402-4     Document Type: Article

References (56)

1. Opioid peptide expression following excitotoxic spinal cord injury
2. Behavioral evidence for a bidirectional effect of systemic naloxone in a model of experimental neuropathy in the rat
3. Blockade of the glycine modulatory site of NMDA receptors modifies dynorphin-induced behavioral effects
4. Competitive and non-competitive NMDA antagonists limit dynorphin A-induced rat hindlimb paralysis
5. Post-spinal cord injury pain states
6. Central dysesthetisa syndrome in SCI patients
7. Effects of IL-10 on pain behaviors following excitotoxic spinal cord injury
8. Tactile allodynia, but not thermal hyperalgesia, of the hindlimbs is blocked by spinal transection in rats with nerve injury
9. Loss of antiallodynic and antinociceptive spinal/supraspinal morphine synergy in nerve-injured rats: Restoration by MK-801 or dynorphin antiserum
10. Excitotoxic spinal cord injury induces diencephalic changes in gene expression
11. Naloxone alters pain perception and somatosensory evoked potentials in normal subjects
12. Intrathecal dynorphin (1-13) results in an irreversible loss of the tail-flick reflex in rats
13. Influence of dynorphin (1-13) on spinal reflexes in the rat
14. Effects of traumatic injury on dynorphin immunoreactivity in spinal cord
15. Morphological characterization of excitotoxic injury in the rat spinal cord
16. Function-limiting dysesthetic pain syndrome among traumatic spinal cord injury patients: A cross-sectional study
17. Upregulation of opioid gene expression in spinal cord evoked by experimental nerve injuries and inflammation
18. Pain following spinal cord injury
19. Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation
20. Lack of effect of naloxone on pain perception in humans
21. Opioid and nonopioid mechanisms may contribute to dynorphin's pathophysiological actions in spinal cord injury
22. Dynorphin-related peptides cause motor dysfunction in the rat through a non-opiate action
23. Endogenous opioid immunoreactivity in rat spinal cord following traumatic injury
24. Placebo and naloxone can alter postsurgical pain by separate mechanisms
25. Effects of eight-hour naloxone infusions in human subjects
26. Treatment of a chronic allodynia-like response in spinally injured rats: Effects of systemically administered excitatory amino acid receptor antagonists
27. Evidence that spinal endogenous opioidergic systems control the expression of chronic pain-related behaviors in spinally injured rats
28. Intrahippocampal NMDA administration alters fos, fos-related antigens, and opioid peptide immunoreactivity and mRNA in rats
29. Effects of spinal kappa-opioid receptor agonists on the responsiveness of nociceptive superficial dorsal horn neurons
30. Physiological relevance and time course of a tonic endogenous opioid modulation of nociceptive messages, based on the effects of naloxone in a rat model of localized hyperalgesic inflammation
31. Factors associated with acute and chronic pain following spinal cord injuries
32. Effects of selective and non-selective κ-opioid receptor agonists on cutaneous C-fibre-evoked responses of rat dorsal horn neurones
33. Opioid peptides and their receptors
34. Spinally administered dynorphin A produces long-lasting allodynia: Involvement of NMDA but not opioid receptors
35. Redox manipulation of NMDA receptors in vivo: Alteration of acute pain transmission and dynorphin-induced allodynia
36. NMDA and non-NMDA receptor antagonists protect against excitotoxic injury in the rat spinal cord
37. Dynorphin A-induced rat spinal cord injury: Evidence for excitatory amino acid involvement in a pharmacological model of ischemic spinal cord injury
38. Phantom body pain in paraplegics: Evidence for a central 'pattern generating mechanism: For pain
39. Multiple opioid systems and pain
40. Chronic, selective forebrain responses to excitotoxic dorsal horn injury
41. Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons
42. Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with fos and fos-related proteins
43. In situ hybridization histochemistry and immunocytochemistry reveal an increase in spinal dynorphin biosynthesis in a rat model of peripheral inflammation and hyperalgesia
44. Regulation of spinal neuropeptide genes in a rat model of peripheral inflammation and hyperalgesia
45. Met-Enkephalin-Arg-6-Phe-7 in spinal cord and brain following traumatic injury to the spinal cord: Influence of p-chlorophenylalanine. An experimental study in the rat using radioimmunoassay technique
46. Classification of pain following spinal cord injury
47. Acute amphetamine or metamphetamine alters opioid peptide mRNA expression in rat striatum
48. Dynorphin A and related peptides administered intrathecally in the rat: A search for putative kappa opiate receptor activity
49. Dose-dependent alteration in zif-268 and preprodynorphin mRNA expression induced by amphetamine or metamphetamine in rat forebrain
50. Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus
51. Chronic pain-related syndrome in rats after ischemic spinal cord lesion: A possible animal model for pain in patients with spinal cord injury
52. Opioid receptor systems and the endorphins: A review of their spinal organization
53. Sites of action of opiates in production of analgesia
54. Neuronal degeneration and spinal cavitation following intraspinal injections of quisqualic acid in the rat
55. Neuronal damage following the intraspinal injection of a nitric oxide synthase inhibitor in the rat
56. Excitotoxic spinal cord injury: Behavioral and morphological characteristics of a central pain model