Substituted benzopyranobenzothiazinones. Synthesis and estrogenic activity on MCF-7 breast carcinoma cells

European Journal of Medicinal Chemistry

Volumn 36, Issue 2, 2001, Pages 127-136

  Jacquot, Yves ^a   Bermont, Laurent ^a,b   Giorgi, Hervé ^a   Refouvelet, Bernard ^a   Adessi, Gerard L ^b   Daubrosse, Edwige ^a   Xicluna, Alain ^a  

^a UNIVERSITÉ DE FRANCHE COMTÉ   (France)

^b CRI 9601   (France)

Author keywords

2D NMR; Benzopyranobenzothiazinones; Binding assay; Estrogenic activity; SAR

Indexed keywords

2 AMINOTHIOPHENOL; 2 BROMO 6,12 DIHYDRO 1 BENZOPYRANO[3,4 B][1,4]BENZOTHIAZIN 6 ONE; 2 CHLORO 6,12 DIHYDRO 1 BENZOPYRANO[3,4 B][1,4]BENZOTHIAZIN 6 ONE; 4 HYDROXYCOUMARIN DERIVATIVE; 6,12 DIHYDRO 1 BENZOPYRANO[3,4 B][1,4]BENZOTHIAZIN 6 ONE; 6,12 DIHYDRO 2 METHYL 1 BENZOPYRANO[3,4 B][1,4]BENZOTHIAZIN 6 ONE; 6,12 DIHYDRO 3 HYDROXY 1 BENZOPYRANO[3,4 B][1,4]BENZOTHIAZIN 6 ONE; 6,12 DIHYDRO 3 METHOXY 1 BENZOPYRANO[3,4 B][1,4]BENZOTHIAZIN 6 ONE; ANTIESTROGEN; BENZOTHIAZINE DERIVATIVE; ESTRADIOL; ESTROGEN RECEPTOR; ETHINYLESTRADIOL; FULVESTRANT; PHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ESTROGEN ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; REPORTER GENE;

BENZOPYRANS; BREAST NEOPLASMS; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL CONGENERS; FEMALE; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; RECEPTORS, ESTROGEN; THIAZINES; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED;

EID: 0035246363     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(00)01207-1     Document Type: Article

References (37)