The Na+/Ca2+ exchanger as a culprit of myocardial stunning;El intercambiador Na+/Ca2+ como responsable del atontamiento miocardico

Medicina

Volumn 61, Issue 2, 2001, Pages 167-173

  Mosca, Susana M ^b   Cingolani, Horacio E ^a  

^a UNIVERSIDAD NACIONAL DE LA PLATA   (Argentina)

^b NONE

Author keywords

Ischemia; Myocardial stunning; Na+ ca2+ blockade; Na+ h+ blockade

Indexed keywords

2 (2 (4 (4 NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA METHANESULFONATE; 2-(2-(4-(4-NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA METHANESULFONATE; ANTIARRHYTHMIC AGENT; CARIPORIDE; DRUG DERIVATIVE; GUANIDINE DERIVATIVE; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN; SULFONE; THIOUREA;

ANIMAL; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; HEART CONTRACTION; HEART MUSCLE ISCHEMIA; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; STUNNED HEART MUSCLE; TIME;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; GUANIDINES; MYOCARDIAL CONTRACTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL STUNNING; RATS; SODIUM-CALCIUM EXCHANGER; SODIUM-HYDROGEN ANTIPORTER; SULFONES; THIOUREA; TIME FACTORS;

EID: 0035235083     PISSN: 00257680     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Heyndrickx GR, Millard RW, McRitchie RJ, Maroko PR, Vatner F. Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs. J Clin Invest 1975; 56: 978-85.
2. Braunwald E, Kloner R . The stunned myocardium: prolonged, postischemic ventricular dysfunction. Circulation 1982; 66: 1146-49.
3. i in perfused hearts: critical evaluation of the 5F-BAPTA and nuclear magnetic resonance method as applied to the study of ischemia and reperfusion. Circ Res 1990; 66: 1255-67.
4. +2 responsiveness and stunned rat ventricular myocardium: relative roles of soluble cytosolic factors versus structural alterations. Circ Res 1996; 78: 455-65.
5. Bolli R. Mechanism of myocardial & quot;stunning". Circulation 1990; 82: 723-38.
6. Carrozza JP Jr, Bentivegna LA, Williams CP, Kuntz RE, Grossman W, Morgan JP. Decreased myofilament responsiveness in myocardial stunning follows transient calcium overload during ischemia and reperfusion. Circ Res 1992; 71: 1334-40.
7. Gao WD, Atar D, Liu Y, Pérez NG, Murphy AM, Marban E. Role of troponin l proteolysis in the pathogenesis of stunned heart. Circ Res 1997; 80: 393-99.
8. + exchanger activity does not contribute to protection by ischemic preconditioning in the isolated rat heart. Circulation 1997; 96:3617-25.
9. 2+ exchange inhibitor, on myocardial ischemia/reperfusion injury. Nippon Yakurigaku Zasshi 1998; 111:105-15.
10. Mosca SM, Gelpi RJ, Cingolani HE. Adenosine and dipyridamole mimic the effects of ischémic preconditioning. J Mol. Cell Cardiol 1994; 26: 1403-9.
11. +2 exchange in cells expressing NCX1. J Biol Chem 1996; 271: 22391-97.
12. 2+ exchange. Circ Res 1989; 65: 1045-56.
13. +2 overload in rat ventricular myocytes. Circulation 2000; 101: 1441-46.
14. 2+ exchanger. Am J Physiol 1999; 276 (Heart Circ Physiol 45): H1868-76.
15. + exchange. Basic Res Cardiol 1996; 91: 203-9.
16. 2+ overload in isolated perfused rabbit heart. Circulation 1994; 89: 2787-98.
17. Scholz W, Aibus U, Counillon H, Gögelein H, Lang HJ, Linz W, Weichert A, Schölkens BA. Protective effects of HOE 642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc Res 1995; 29: 260-68.
18. + exchange inhibition in a regionally ischemic, reperfused oorcine heart preparation with low residual blood flow. J Mol Cell Cardiol 1998; 30: 795-801.
19. Gumina RJ, Mizumura T, Beier N, Schelling P, Schultz JJ, Gross GJ. A new sodium/hydrogen exchange inhibitor, EMD 85131 limits infarct size in dogs when administered before and after coronary occlusion. J Pharmacol Exp Ther 1998; 286:175-83.
20. Vanheel B, deHemptinne A, Leusen I. Acidification and intracellular sodium activity during simulated myocardial ischemia. Am J Physiol 1990; 259: C169-79.
21. 23Na-NMR measurements of intracellular sodium in intact perfused ferret hearts during ischemia and reperfusion. Am J Physiol 1990; 259 (Heart Circ physiol 28): H 1767-73.
22. Reeves JP, Bailey CA, Hale CC. Redox modification of sodium-calcium exchange activity in cardiac sarcolemmal vesicles. J Biol Chem 1986; 261: 4948-55.
23. Corretti M, Koretsune Y, Kusuoka H, Chacko VP, Zweier JL, Marban E. Glycolytic inhibition and calcium overload as consequences of exogenously-generated free radicals in rabbit hearts. J Clin Invest 1991; 88: 1014-25.
24. Barry WH, Brooks WW, Messer JV. Heart muscle viability following hipoxia: protective effect of acidosis. Science 1973; 180: 1297-8.
25. Ventura-Clapier R, Veksler V. Myocardial contracture. Metabolites affect rigor tension development and stiffness. Circ Res 1994; 74: 920-29.