Multiple substrates of late-onset dementia: Implications for brain protection

Novartis Foundation Symposium

Volumn 235, Issue , 2001, Pages 49-65

  Kalaria, R N ^a   Ballard, C G ^a   Ince, P G ^a   Kenny, R A ^a   McKeith, I G ^a   Morris, C M ^a   O'Brien, J T ^a   Perry, E K ^a   Perry, R H ^a   Edwardson, J A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E;

ALZHEIMER DISEASE; BRAIN; CARDIOVASCULAR MALFORMATION; CEREBROVASCULAR DISEASE; DEMENTIA; DIFFUSE LEWY BODY DISEASE; GENETICS; GENOTYPE; HUMAN; METABOLISM; MULTIINFARCT DEMENTIA; ONSET AGE; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; RISK FACTOR;

AGE OF ONSET; ALZHEIMER DISEASE; APOLIPOPROTEINS E; BRAIN; CARDIOVASCULAR ABNORMALITIES; CEREBROVASCULAR DISORDERS; DEMENTIA; DEMENTIA, VASCULAR; GENOTYPE; HUMANS; LEWY BODY DISEASE; RISK FACTORS;

EID: 0035227582     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (40)

1. Ballard C, Shaw F, McKeith I, Kenny RA 1998 High prevalence of neurovascular instability in neurodegenerative dementias. Neurology 51:1760-1762
2. Ballard C, McKeith I, O'Brien J et al 2000 Neuropathological substrates of dementia and depression in vascular dementia, with a particular focus on cases with small infarct volumes. Dement Geriatr Cogn Disord 11:59-65
3. Corey-Bloom J, Sabbagh MN, Bondi MW et al 1997 Hippocampal sclerosis contributes to dementia in the elderly. Neurology 48:154-160
4. Erkinjuntti T, Sawada T, Whitehouse PJ 1999 Summary of the 1st international conference on development of drug treatment for vascular dementia. Alz Dis Assoc Dis J 13:S1-S3
5. Esiri M, Wilcock GK, Morris JH 1997 Neuropathological assessment of the lesions of significance in vascular dementia. J Neurol Neurosurg Psychiatry 63:749-753
6. Farrer LA, Cupples LA, Haines J et al 1997 Effects of age, gender and ethnicity on the association of apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 278:1349-1356
7. Gottfries CG, Blennow K, Karlsson I, Wallin A 1994 The neurochemistry of vascular dementia. Dementia 5:163-167
8. Greenberg SM, Vonsattel JP, Segal AZ et al 1998 Association of apolipoprotein E epsilon2 and vasculopathy in cerebral amyloid angiopathy. Neurology 50:961-965
9. Heyman A, Fillenbaum GG, Welsh-Bohmer KA et al 1998 Cerebral infarcts in patients with autopsy-proven Alzheimer's disease. CERAD Part XVIII. Consortium to Establish a Registry for Alzheimer's Disease. Neurology 51:159-162
10. Hofman A, Ott A, Breteler MMB 1997 Atherosclerosis, apolipoprotein E, and the prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet 349:151-154
11. Ince PG, McArthur FK, Bjertness E, Torvik A, Candy JM, Edwardson JA 1995 Neuropathological diagnoses in elderly patients in Oslo: Alzheimer's disease, Lewy body disease, vascular lesions. Dementia 6:162-168
12. Ince PG, Perry EK, Morris CM 1998 Dementia with Lewy bodies. A distinct non-Alzheimer dementia syndrome? Brain Pathol 8:299-324
13. Kalaria RN 1996 Cerebral vessels in ageing and Alzheimer's disease. Pharmacol Ther 72:193-214
14. Kalaria RN 1997 Apolipoprotein E, arteriosclerosis and Alzheimer's disease. Lancet 349:1174
15. Kalaria RN 2000a The impact of risk factors for stroke on Alzheimer's disease. Neurobiol Aging 21:321-330
16. Kalaria RN 2000b The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease. Ann NY Acad Sci 893:113-125
17. Kalaria RN, Ballard CG 1999 Overlap between the pathology of Alzheimer disease and vascular dementia. Alzheimer Dis Assoc Disord 13:S115-S123
18. Kalaria RN, Ogeng'o JA, Patel NB et al 1997 Evaluation of risk factors for Alzheimer's disease in elderly east Africans. Brain Res Bull 44:573-577
19. Kalmijn S, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM 1997 Dietary-fat intake and the risk of incident dementia in the Rotterdam study. Ann Neurol 42:776-782
20. Kenny RA 1996 Syncope in the older patient. In: Kenny RA (ed) Syncope, 1st edn. Chapman & Hall, London, p 1-15
21. Kokmen E, Whisnant JP, O'Fallon WM, Chu CP, Beard CM 1996 Dementia after ischemic stroke: a population-based study in Rochester, Minnesota (1960-1984). Neurology 46: 154-159
22. Lipsitz LA 1996 Abnormalities in blood pressure regulation. Dementia 9:33-46
23. McCarron MO, Nicoll JA 1998 High frequency of apolipoprotein E epsilon 2 allele is specific for patients with cerebral amyloid angiopathy-related haemorrhage. Neurosci Lett 247:45-48
24. McKeith IG, O'Brien JT, Ballard CG 1999 Diagnosing dementia with Lewy bodies. Lancet 354:1227-1228
25. Morris CM, Massey HM, Benjamin R et al 1996 Molecular biology of APO E alleles in Alzheimer's and non-Alzheimer's dementias. J Neural Transm Suppl 47:205-218
26. Nolan KA, Lino MM, Seligmann AW, Blas JP 1998 Absence of vascular dementia in an autopsy series from a dementia clinic. J Am Geriatr Soc 46:597-604
27. Orgogozo JM, Dartigues JF, Lafont S et al 1997 Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area. Rev Neurol (Paris) 153:185-192
28. Osuntokun BO, Sahota A, Ogunniyi AO et al 1995 Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians. Ann Neurol 38:463-465
29. Perry E, Walker M, Grace J, Perry R 1999 Acetylcholine in mind: a neurotransmitter correlate of consciousness? Trends Neurosci 22:273-280
30. Petot GJ, Cole R, Debanne SM et al 1995 Adult lifetime dietary intake patterns of antioxidant nutrients and foods in a case control study of risk factors for Alzheimer's disease: preliminary data. Neuroepidemiology 14:6
31. Piggott M, Perry E, Marshall E et al 1998 Nigrostriatal dopaminergic activities in Dementia with Lewy bodies in relation to neuroleptic sensitivity: comparisons with Parkinson's disease. Biol Psychiatry 44:765-774
32. Poehlman ET, Dvorak RV 2000 Energy expenditure, energy intake and weight loss in Alzheimer disease. Am J Clin Nutr 71:650S-655S
33. Poirier J, Sevigny P 1998 Apolipoprotein E4, cholinergic integrity and the pharmacogenetics of Alzheimer's disease. J Neural Transm Suppl 105:199-207
34. Premkumar DRD, Cohen DL, Hedera P, Friedland RP, Kalaria RN 1996 Apolipoprotein E ε4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology in Alzheimer's disease. Am J Pathol 148:2083-2095
35. Skoog I 1998 A review of blood pressure and ischaemic white matter lesions. Dement Geriatr Cogn Disord (suppl 1) 9:13-19
36. Skoog I, Vanmechelen E, Andreasson LA et al 1995 A population-based study of tau protein and ubiquitin in cerebrospinal fluid in 85-year-olds: relation to severity of dementia and cerebral atrophy, but not to the apolipoprotein E4 allele. Neurodegeneration 4:433-442
37. Slooter AJ, Cruts M, Ott A et al 1999 The effect of APOE on dementia is not through atherosclerosis: the Rotterdam Study. Neurology 53: 1593-1595
38. Snowdon DA, Greiner LH, Mortimer JA et al 1997 Brain infarction and the clinical expression of Alzheimer's disease: the Nun study. JAMA 277:813-817
39. Van der Cammen TJM, Vershoor CJ, Van Loon CPM, et al 1998 Risk of left ventricular dysfunction in patients with probable Alzheimer's disease with APOE*4 allele. J Am Geriatr Soc 46:962-967
40. Zhan SS, Beyreuther K, Schmitt HP 1994 Synaptophysin immunoreactivity of the cortical neuropil in vascular dementia of Binswanger type compared with the dementia of the Alzheimer type and nondemented controls. Dementia 5:79-87