E2 supplementation selectively relieves GH's autonegative feedback on GH-releasing peptide-2-stimulated GH secretion

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 12, 2001, Pages 5904-5911

  Anderson, S M ^a   Wideman, L ^a   Patrie, J T ^a   Weltman, A ^a   Bowers, C Y ^a   Veldhuis, J D ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE RELEASING FACTOR RECEPTOR; HUMAN GROWTH HORMONE; PRALMORELIN; SODIUM CHLORIDE;

ADULT; ARTICLE; AUTOREGULATION; BLOOD SAMPLING; CHEMOLUMINESCENCE; CONTROLLED STUDY; ESTROGEN ACTIVITY; FEEDBACK SYSTEM; FEMALE; GONAD FUNCTION; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; NORMAL HUMAN; POSTMENOPAUSE; PRIORITY JOURNAL; SUPPLEMENTATION;

ADMINISTRATION, ORAL; ESTRADIOL; FEEDBACK; FEMALE; GROWTH HORMONE-RELEASING HORMONE; HUMAN GROWTH HORMONE; HUMANS; INJECTIONS, INTRAVENOUS; MIDDLE AGED; OLIGOPEPTIDES; POSTMENOPAUSE; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS;

HUMAN ECHOVIRUS 1;

EID: 0035215942     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.86.12.5904     Document Type: Article

References (68)

1. Effects of sex and age on the 24-hour profile of growth hormone secretion in man: Importance of endogenous estradiol concentrations
2. Proposed mechanisms of sex-steroid hormone neuromodulation of the human GH-IGF-I axis
3. Pathophysiology of the neuroregulation of GH secretion in experimental animals and the human
4. Human growth hormone and human aging
5. Clinical aspects of growth hormone deficiency in adults
6. The newer uses of growth hormone in adults
7. Growth hormone pretreatment in man blocks the response to growth hormone-releasing hormone: Evidence for a direct effect of growth hormone
8. Negative feedback suppression of sleep-related growth hormone secretion
9. Suppression of the growth hormone (GH) response to clonidine and GH-releasing hormone by exogenous GH
10. Growth hormone releasing hormone (GHRH)-, growth hormone releasing peptide-2 (GHRP-2)-, and exercise-induced GH secretion demonstrate variable degrees of suppressibility by GH autonegative feedback
11. Hexarelin induced growth hormone release is influenced by exogenous growth hormone
12. Mechanisms underlying the negative growth hormone (GH) autofeedback on the GH-releasing effect of hexarelin in man
13. Exogenous growth hormone inhibits growth hormone-releasing factor-induced growth hormone secretion in normal men
14. Acute administration of recombinant human growth hormone inhibits the somatotrope responsiveness to growth hormonereleasing hormone in childhood
15. Arginine reinstates the somatotrope responsiveness to intermittent growth hormone-releasing hormone administration in normal adults
16. Neuroendocrine control of growth hormone secretion
17. Sex difference in growth hormone feedback in the rat
18. Females secrete growth hormone with more process irregularity than males in both human and rat
19. Differential orderliness of the GH release process in castrate male and female rats
20. The specific gravity of healthy men; body weight/volume and other physical characteristics of exceptional athletes and of naval personnel
21. Low basal and persistent pulsatile growth hormone secretion are revealed in normal and hyposomatotropic men studied with a new ultrasensitive chemiluminescence assay
22. Actions of estrogen on the pulsatile, nyctohemeral, and entropic modes of growth hormone secretion
23. The pituitary gland secretes in bursts: Appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations
24. Deconvolution analysis of hormone data
25. Half-time of endogenous growth hormone (GH) disappearance in normal man after stimulation of GH secretion by GH-releasing hormone and suppression with somatostatin
26. Synergistic release of growth hormone by GHRP and GHRH: Scope and implication
27. Growth hormone-releasing and somatostatin concentrations in the hypophysial portal blood of conscious sheep during the infusion of growth hormone-releasing peptide-6
28. Growth hormone (GH)-releasing hormone secretion is stimulated by a new GHreleasing hexapeptide in sheep
29. Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary
30. Insulin-like growth factor-I modulates hypothalamic somatostatin through a growth hormone releasing factor increased somatostatin release and messenger ribonucleic acid levels
31. Synergistic interaction between insulin-like growth factors-I and -II in central regulation of pulsatile growth hormone secretion
32. Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factors-I in growth hormone receptor deficiency syndrome/Laron syndrome
33. IGF feedback effects on growth hormone secretion in ewes: Evidence for action at the pituitary but not the hypothalamic level
34. A receptor in pituitary and hypothalamus that functions in growth hormone release
35. Ghrelin is a growth-hormone-releasing acylated peptide from stomach
36. Growth hormone-releasing hormone receptor (GHRH-R) and growth hormone secretagogue receptor (GHS-R) mRNA levels during postnatal development in male and female rats
37. Sexual dimorphism of growth hormone-releasing hormone and somatostatin gene expression in the hypothalamus of the rat during development
38. Regulation of somatostatin and growth hormonereleasing factor by gonadal steroids in fetal rat hypothalamic cells in culture
39. Gene expression of the receptor for growth-hormone-releasing hormone is physiologically regulated by glucocorticoids and estrogen
40. The effect of testosterone and estrogen on the pituitary, growth hormone response to growth hormone releasing factor
41. Short-term estradiol supplementation augments growth hormone (GH)secretory responsiveness to dose-varying GH-releasing peptide infusions in healthy postmenopausal women
42. The growth hormone response to hexarelin in children: Reproducibility and effect of sex steroids
43. The GH, prolactin, ACTH and cortisol responses to hexarelin, a synthetic hexapeptide, undergo different age-related variations
44. Endocrine responses to GH secretagogues in relation to sex and age in humans
45. Cloning and characterization of the 5′-flanking region of the human growth hormone secretagogue receptor gene
46. Influence of sex, age, and adrenergic pathways on the growth hormone response to GHRP-6
47. Oestrogen replacement does not restore the reduced GH-releasing activity of hexarelin, a synthetic hexapeptide, in postmenopausal women
48. Short-term estradiol replacement in postmenopausal women selectively mutes somatostatin's dose-dependent inhibition of fasting growth-hormone (GH) secretion
49. GH feedback occurs through modulation of hypothalamic somatostatin under cholinergic control: Studies with pyridostigmine and GHRH
50. The decrease in growth hormone (GH) response after repeated stimulation with GH-releasing hormone is partly caused by an elevation of somatostatin tonus
51. Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: Evidence that GHRP-6 main action is exerted at the hypothalamic level
52. Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone
53. Aging effects on growth hormone receptor binding in the brain
54. 1996 Differential regulation of the growth hormone receptor gene: Effects of dexamethasone and estradiol
55. Oral estradiol administration modulates continuous intravenous growth hormone (GH)-releasing peptide-2 driven GH secretion in postmenopausal women
56. Estrogen and testosterone, but not a non-aromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: Evidence from pubertal pathophysiology and sex-steroid hormone replacement
57. Tripartite neuroendocrine activation of the human growth-hormone (GH) axis in women by continuous 24-hour GH-releasing peptide (GHRP-2) infusion: Pulsatile, entropic, and nyctohemeral mechanisms
58. Secretory process regularity monitors neuroendocrine feedback and feedforward signaling strength in humans
59. Quantification of hormone pulsatility via an approximate entropy algorithm
60. Regulation of growth hormone and somatomedin-C secretion in postmenopausal women: Effect of physiological estrogen replacement therapy
61. Both oral and transdermal estrogen increase growth hormone release in postmenopausal women - A clinical research center study
62. In vivo release of growth hormone-releasing factor from rat hypothalamus: Effect of insulin-like growth factor-I
63. Effect of aging on the sensitivity of growth hormone secretion to insulin-like growth factor-I negative feedback
64. Negative feedback regulation of pulsatile growth hormone secretion by insulin-like growth factor I: Involvement of hypothalamic somatostatin
65. Insulin-like growth factor-I and -II in combination inhibit the release of growth hormone-releasing hormone from the rat hypothalamus in vitro
66. Effects of recombinant human insulin-like growth factor I administration on growth hormone (GH) secretion, both spontaneous and stimulated by GH-releasing hormone or hexarelin, a peptidyl GH secretagogue, in humans