Estrogen reduces the depth of resorption pits by disturbing the organic bone matrix degradation activity of mature osteoclasts

Endocrinology

Volumn 142, Issue 12, 2001, Pages 5371-5378

  Parikka, Vilhelmiina ^a,b   Lehenkari, Petri ^b   Sassi, Mirja Liisa ^b   Halleen, Jussi ^a   Risteli, Juha ^b   Härkönen, Pirkko ^a   Väänänen, H Kalervo ^a,c  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN K; COLLAGEN TYPE 1; CYSTEINE PROTEINASE; ESTROGEN; GELATINASE B;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE MATRIX; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CROSS LINKING; DEGRADATION; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ESTROGEN ACTIVITY; MENOPAUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; RAT;

EID: 0035213922     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.12.8533     Document Type: Article

References (48)

1. Estrogen and bone Loss
2. Increased osteoclast development after estrogen loss: Mediation by interleukin-6
3. 17β-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: A potential mechanism for the antiosteoporotic effect of estrogens
4. Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin-land tumor necrosis factor-mediated stimulation of macrophage colony-stimulating factor production
5. Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α
6. Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression
7. Failure of estrogens and androgens to inhibit bone resorption in tissue culture
8. +-ATPase and bone resorption by tamoxifen and calmodulin antagonists. Effects independent of steroid receptors
9. Selective toxic effects of tamoxifen on osteoclasts: Comparison with the effects of oestrogen
10. The effect of sex hormones on bone resorption by rat osteoclasts
11. Avian osteoclasts as estrogen target cells
12. Mammalian mature osteoclasts as estrogen target cells
13. Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts
14. Removal of osteoclast bone resorption products by transcytosis
15. Trafficking of matrix collagens through bone-resorbing osteoclasts
16. High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development
17. Identification of matrix metalloproteinase 9 in rabbit osteoclasts
18. Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts
19. Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts
20. Applications of an enzyme immunoassay for a new marker of bone resorption (CrossLaps): Follow-up on hormone replacement therapy and osteoporosis risk assessment
21. Serum CrossLaps One Step ELISA. First application of monoclonal antibodies for measurement in serum of bone-related degradation products from C-terminal telopeptides of type I collagen
22. Effect of the menopause and hormone replacement therapy on the carboxy-terminal pyridinoline cross-linked telopeptide of type 1 collagen
23. The carboxy-terminal pyridinoline cross-linked telopeptide of type 1 collagen in serum as a marker of bone resorption: The effect of nandrolone decanoate and hormone replacement therapy
24. Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment
25. Increased type 1 collagen degradation correlates with disease severity in rheumatoid arthritis
26. Usefulness of bone metabolic markers in the diagnosis and follow-up of bone metastasis from lung cancer
27. Organization of osteoclast microfilaments during the attachment to bone surface in vitro
28. The effects of bisphosphonates on the resorption cycle of isolated osteoclasts
29. Comparison of bone resorption markers during hypocalcemia in dairy cows
30. Immunochemical characterization of assay for carboxyterminal telopeptide of human type I collagen: Loss of antigenicity by treatment with cathepsin K
31. Time course of vertebral osteopenia in ovariectomized rats
32. Hormone replacement therapy prevents osteoclastic hyperactivity: A histomorphometric study in early postmenopausal women
33. Osteoclasts isolated from membranous bone in children exhibit nuclear estrogen and progesterone receptors
34. Estrogen modulation of avian osteoclast lysosomal gene expression
35. Endocytic pathway from the basal plasma membrane to the ruffled border membrane in bone-resorbing osteoclasts
36. Cell-mediated extracellular acidification and bone-resorption: Evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border
37. Regulation of collagenolytic cysteine protease synthesis by estrogen in osteoclasts
38. Cathepsin K antisense oligodeoxynucleotide inhibits osteoclastic bone resorption
39. Localization of rat cathepsin K in osteoclasts and resorption pits: Inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones
40. Immunohistochemical localization of cathepsins B, D and L in the rat osteoclast
41. Cathepsin B and L activities in isolated osteoclasts
42. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency
43. Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis
44. Determination of bone markers in pycnodysostosis: Effects of cathepsin K deficiency on bone matrix degradation
45. Expression of 92 kD type IV collagenase/gelatinase B in human osteoclasts
46. The collagenolytic activity of cathepsin K is unique among mammalian proteinases
47. Initiation of osteoclast bone resorption by interstitial collagenase
48. The migration of purified osteoclasts through collagen is inhibited by matrix metalloproteinase inhibitors