Inhibition of wild-type and mutant neuronal nicotinic acetylcholine receptors by local anesthetics

Molecular Pharmacology

Volumn 60, Issue 6, 2001, Pages 1365-1374

  Papke, R L ^a   Horenstein, B A ^a   Placzek, A N ^a  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; LIDOCAINE ETHOBROMIDE; LOCAL ANESTHETIC AGENT; MUTANT PROTEIN; NICOTINIC RECEPTOR; RECEPTOR SUBUNIT; TETRACAINE;

ADOLESCENT; ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; FEMALE; IC 50; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RECEPTOR SENSITIVITY;

EID: 0035210795     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.60.6.1365     Document Type: Article

References (12)

1. An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor
2. Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor
3. Sensitivity to voltage-independent inhibition determined by pore-lining region of ACh receptor
4. Molecular biology of the muscle and neural acetylcholine receptors
5. Asymmetry of the acetylcholine channel revealed by quaternary anesthetics
6. 3H]tetracaine, a nondesensitizing noncompetitive antagonist
7. Genetic manipulation of ion channels: A new approach to structure and mechanism
8. The charge carried by single-channel currents of rat cultured muscle cells in the presence of local anesthetics
9. Mechanisms of noncompetitive inhibition of acetylcholine-induced single channel currents
10. Delimiting the binding site for quaternary ammonium lidocaine derivatives in the acetylcholine receptor channel
11. A structure-based approach to nicotinic receptor pharmacology
12. Antagonist activities of mecamylamine and nicotine show reciprocal dependence on beta subunit sequence in the second transmembrane domain