Delimiting the binding site for quaternary ammonium lidocaine derivatives in the acetylcholine receptor channel

Journal of General Physiology

Volumn 112, Issue 5, 1998, Pages 611-621

  Pascual, Juan M ^a   Karlin, Arthur ^a  

^a Howard Hughes Medical Institute   (United States)

Author keywords

Cysteine mutagenesis; Methanethiosulfonate; Open channel block; Reaction kinetics

Indexed keywords

2 AMINOETHYLMETHANE THIOSULFONIC ACID; ACETYLCHOLINE; CHOLINERGIC RECEPTOR; CYSTEINE; GLUTAMIC ACID; LEUCINE; LIDOCAINE DERIVATIVE; LIDOCAINE ETHOBROMIDE; N [(2,6 DIMETHYLPHENYL)CARBAMOYLMETHYL]TRIMETHYLAMMONIUM; QUATERNARY AMMONIUM DERIVATIVE; RECEPTOR SUBUNIT; SERINE; SULFONIC ACID DERIVATIVE; TRIMETHYLAMMONIUM SALT DERIVATIVE; UNCLASSIFIED DRUG; VALINE;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; NONHUMAN; OOCYTE; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANESTHETICS, LOCAL; ANIMALS; BINDING SITES; CYSTEINE; CYTOPLASM; ELECTROPHYSIOLOGY; INDICATORS AND REAGENTS; ION CHANNEL GATING; KINETICS; LIDOCAINE; MESYLATES; MICE; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PROTEIN CONFORMATION; RECEPTORS, CHOLINERGIC; XENOPUS;

EID: 0031772578     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.112.5.611     Document Type: Article

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