Acute valproate-associated microvesicular steatosis: Could the [13C]methionine breath test be useful to assess liver mitochondrial function?

Digestive Diseases and Sciences

Volumn 46, Issue 12, 2001, Pages 2758-2761

  Spahr, Laurent ^a   Negro, Francesco ^a   Rubbia Brandt, Laura ^a   Marinescu, Oana ^a   Goodman, Keith ^b   Jordan, Martha ^a   Frossard, Jean Louis ^a   Hadengue, Antoine ^a  

^a UNIVERSITY HOSPITAL   (Switzerland)

^b METABOLIC SOLUTIONS INC   (United States)

Author keywords

Breath test; Decarboxylation; Drug induced liver injury; Electron microscopy; Methionine; Microvesicular steatosis; Mitochondria; Overdose; Valproate

Indexed keywords

ACTIVATED CARBON; ALPRAZOLAM; METHIONINE; METHIONINE C 13; OLANZAPINE; UNCLASSIFIED DRUG; VALPROIC ACID;

ADULT; ARTICLE; BREATH ANALYSIS; CASE REPORT; CLINICAL FEATURE; CONTROLLED STUDY; DRUG OVERDOSE; FATTY LIVER; FEMALE; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER FUNCTION TEST; LIVER MITOCHONDRION; LIVER TOXICITY; PRIORITY JOURNAL;

ADULT; ANTIMANIC AGENTS; BREATH TESTS; FEMALE; HEPATOCYTES; HUMANS; LIVER FAILURE; METHIONINE; MITOCHONDRIA, LIVER; OVERDOSE; VALPROIC ACID;

EID: 0035208158     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012791832730     Document Type: Article

References (14)

1. Hepatotoxicity to sodium valproate: A review
2. Fatal liver failure associated with valproate therapy in a patient with Friedreich's disease: Review of valproate hepatotoxicity in adults
3. Sodium valproate and ornithine carbamyl transferase deficiency
4. 1996 Annual report of the American Association of Poison Control Centers toxic exposure surveillance system
5. Impaired mitochondrial function in microvesicular steatosis. Effects of drugs, ethanol, hormones and cytokines
6. Disorders of the mitochondria
7. Hepatotoxicity in rat following administration of valproic acid
8. 13C-urea breath test
9. Fatal sodium valproate poisoning
10. Effects of long-term administration of the antiepileptic drug-sodium valproate upon the ultrastructure of hepatocytes in rats
11. The mitochondrial permeability transition: A new pathophysiological mechanism for Reye's syndrome and toxic liver injury
12. Mitochondrial dysfunction in alcoholic patients as assessed by breath analysis
13. S-Adenosylmethionine synthesis: Molecular mechanisms and clinical implications
14. Identification of 3-methylthiopropionic acid as an intermediate in mammalian methionine metabolism in vitro