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Volumn 49, Issue 12, 2001, Pages 1593-1603

Synthesis and structure-activity relationships in a series of ethenesulfonamide derivatives, a novel class of endothelin receptor antagonists

(10) Harada, Hironori a Kazami, Jun Ichi a Watanuki, Susumu a Tsuzuki, Ryuji b Sudoh, Katsumi a Fujimori, Akira a Tokunaga, Tatsuhiro a Tanaka, Akihiro b Tsukamoto, Shin Ichi a Yanagisawa, Isao a

a Yamacnouchi Pharmaceutical Co Ltd (Japan)

b ASTELLAS PHARMA INC (Japan)

Author keywords

Endothelin antagonist; Endothelin A selective antagonist; Endothelin A endothelin B mixed antagonist; Ethenesulfonamide

Indexed keywords

ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; ETHENESULFONAMIDE DERIVATIVE; N [6 METHOXY 5 (2 METHOXYPHENOXY) 2 (PYRIMIDIN 2 YL)PYRIMIDIN 4 YL] 1 ETHYL 2 PHENYLETHENESULFONAMIDATE; N [6 METHOXY 5 (2 METHOXYPHENOXY) 2 (PYRIMIDIN 2 YL)PYRIMIDIN 4 YL] 2 (2,4,6 TRIMETHYLPHENYL)ETHENESULFONAMIDE; PHENYL GROUP; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; MALE; NONHUMAN; PRESSOR RESPONSE; RAT; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BLOOD PRESSURE; CLONING, MOLECULAR; COS CELLS; DECEREBRATE STATE; ENDOTHELIN-1; ENDOTHELINS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PROTEIN PRECURSORS; RATS; RATS, WISTAR; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0035205299 PISSN: 00092363 EISSN: None Source Type: Journal
DOI: 10.1248/cpb.49.1593 Document Type: Article

Times cited : (11)

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