Detection of oxidative species and low-molecular-weight DNA in skin following dermal exposure with JP-8 jet fuel

Journal of Applied Toxicology

Volumn 21, Issue 6, 2001, Pages 521-525

  Rogers, James V ^a   Gunasekar, Palur G ^a   Garrett, Carol M ^b   Kabbur, Mahendra B ^c   McDougal, James N ^a  

^a SCIENCE APPLICATIONS INTERNATIONAL CORPORATION   (United States)

^b WRIGHT STATE UNIVERSITY   (United States)

^c AIR FORCE RESEARCH LABORATORY   (United States)

Author keywords

DNA fragmentation; Jet fuel; JP 8; Oxidative species; Skin

Indexed keywords

DNA; FUEL;

ABSORPTION; AIRCRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPOSURE; MALE; MOLECULAR WEIGHT; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; SKIN INJURY; SKIN IRRITATION;

ABSORPTION; ADMINISTRATION, CUTANEOUS; AIRCRAFT; ANIMALS; DNA DAMAGE; HYDROCARBONS; KEROSENE; MALE; RATS; RATS, INBRED F344; REACTIVE OXYGEN SPECIES; SKIN; VOLATILIZATION;

EID: 0035203812     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jat.799     Document Type: Article

References (39)

1. Effect of chronic low-level exposure to jet fuel on postural balance of US Air Force personnel
2. Inhalation exposure to JP-8 jet fuel alters pulmonary function and substance P levels in Fischer 344 rats
3. Neutral endopeptidase (NEP) and its role in pathological pulmonary change with inhalation exposure to JP-8 jet fuel
4. Immunotoxicological effects of JP-8 jet fuel exposure
5. Short-term exposure to JP-8 jet fuel results in long-term immunotoxicity
6. Effects of short-term JP-8 jet fuel exposure on cell-mediated immunity
7. Evaluation of skin sensitization potential of jet fuels by murine local lymph node assay
8. Dermal application of JP-8 jet fuel induces immune suppression
9. Assessment of skin absorption and penetration of JP-8 jet fuel and its components
10. Percutaneous absorption and skin irritation of JP-8 (jet fuel)
11. A 90-Day toxicity study of the effects of petroleum middle distillates on the skin of C3H mice
12. The role of dermal irritation in the skin tumor promoting activity of petroleum middle distillates
13. Evaluation of the contribution of chronic skin irritation and selected compositional parameters to the tumorigenicity of petroleum middle distillates in mouse skin
14. Identification of early biomarkers of inflammation produced by keratinocytes exposed to jet fuels Jet A, JP-8, and JP-8(100)
15. JP-8 jet fuel-induced DNA damage in H4IIE rat hepatoma cells
16. Investigation of in vitro toxicity of jet fuels JP-8 and Jet A
17. Mechanisms of JP-8 jet fuel toxicity. II. Induction of necrosis in skin fibroblasts and keratinocytes and modulation of levels of bcl-2 family members
18. Mechanisms of JP-8 jet fuel toxicity. I. Induction of apoptosis in rat lung epithelial cells
19. Effect of JP-8 jet fuel on molecular and histological parameters related to acute skin irritation
20. Physiologically based modeling of nonsteady state dermal absorption of halogenated methanes from an aqueous solution
21. 2 in cultured endothelial cells
22. Cyanide-induced apoptosis involves oxidative-stress-activated NF-κB in cortical neurons
23. Induction and excretion of ultraviolet-induced 8-oxo-2′-deoxyguanosine and thymine dimmers in vivo: Implications for PUVA
24. Redoxmodulated pathways in inflammatory skin diseases
25. Age-related changes in oxidative damage to lipids and DNA
26. Measurement of cellular repair activities for oxidative DNA damage
27. Skin low molecular weight antioxidants and their role in aging and in oxidative stress
28. Quantification of the overall reactive oxygen species scavenging capacity of biological fluids and tissues
29. Biochemical and neurotoxicology: Relevance to biomarker development, neurotoxicity testing and risk assessment
30. Biological monitoring in occupational and environmental toxicology
31. Biomarkers in toxicology
32. Use of biomarkers - New frontiers in occupational toxicology and epidemiology
33. New aspects in genotoxic risk assessment of styrene exposure - A working hypothesis
34. Comparison of the mutations induced by p-benzoquinone, a benzene metabolite, in human and mouse cells
35. Carcinogenicity and genotoxicity of ethylene oxide: New aspects and recent advances
36. Oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin: An application of oxidative stress markers to cancer risk assessment of dioxins
37. Short-term pulmonary response to inhaled JP-8 jet fuel aerosol in mice
38. Proteomic analysis of simulated jet fuel exposure in the lung
39. Dermal exposure to m-xylene leads to increasing oxidative species and low molecular weight DNA levels in rat skin