Ethyl side-chain modifications in novel flexible antiestrogens - design, synthesis and biological efficacy in assay against the MCF-7 breast tumor cell line

Anti-Cancer Drug Design

Volumn 16, Issue 1, 2001, Pages 57-69

  Meegan, M J ^a   Hughes, R B ^a   Lloyd, D G ^a   Williams, D C ^a   Zisterer, D M ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Antiestrogens; Breast cancer; Flexible; Oxidative potential; Tamoxifen

Indexed keywords

1 BENZYL 2 PHENYL [(4 DIMETHYLAMINOETHOXY)PHENYL]BUT 1 ENE; ANTIESTROGEN; ESTROGEN RECEPTOR; HYDROXYTAMOXIFEN; TAMOXIFEN; TOREMIFENE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ADULT; ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; CELL DIVISION; COMPUTER SIMULATION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ESTROGEN ANTAGONISTS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEPATITIS, TOXIC; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PREGNANCY; RECEPTORS, ESTROGEN; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0035203757     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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