In vitro metabolism of a new anticancer agent, 6-N-formylamino-12,13- dihydro-1,11-dihydroxy-13-(β-D-glucopyranosil)5H-indolo [2,3-a]pyrrolo [3,4- c]carbazole-5,7(6H)-dione (NB-506), in mice, rats, dogs, and humans

Drug Metabolism and Disposition

Volumn 27, Issue 2, 1999, Pages 213-220

  Takenaga, N ^a   Hasegawa, T ^a   Ishii, M ^a   Ishizaki, H ^a   Hata, S ^a   Kamei, T ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 FORMYLAMINO 12,13 DIHYDRO 1,11 DIHYDROXY 5H INDOLO[2,3 A][PYRROLO[3,4 C]CARBAZOLE 5,7(6H) DIONE 13 GLUCOSIDE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE; ED 501; ED 551; ED 594; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TACROLIMUS; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DOG; DRUG GLUCURONIDATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIVER MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE;

ANIMALS; ANTINEOPLASTIC AGENTS; BILE; BIOTRANSFORMATION; CARBAZOLES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; GLUCOSIDES; GLUCURONATES; GLUCURONOSYLTRANSFERASE; HUMANS; INTESTINE, SMALL; MALE; MASS SPECTROMETRY; MICE; MICROSOMES, LIVER; NADP; RATS; SPECIES SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET;

ANIMALIA; CANIS FAMILIARIS; RODENTIA;

EID: 0032963583     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

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