The GABA(A) agonist THIP increases non-REM sleep and enhances non-REM sleep-specific delta activity in the rat during the dark period

Sleep

Volumn 20, Issue 12, 1997, Pages 1099-1104

  Lancel, Marike ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

GABA(A) agonist; GABA(A) receptor; Rat; Sleep state; Spectral analysis

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; GABOXADOL; MUSCIMOL;

ADOLESCENT; ARTICLE; CONTROLLED STUDY; DELTA RHYTHM; DRUG EFFECT; ELECTROENCEPHALOGRAM; ELECTROMYOGRAM; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; RAT; SLEEP STAGE;

EID: 0031418191     PISSN: 01618105     EISSN: None     Source Type: Journal    
DOI: 10.1093/sleep/20.12.1099     Document Type: Article

References (28)

1. A receptors in sleep regulation. Differential effects of muscimol and midazolam on sleep in rats. Neuropsychopharmacology 1996; 15:63-74.
2. A agonist THIP (gaboxadol) increases non-REM sleep and enhances delta activity in the rat. Neuroreport 1996;7:2241-5.
3. Lancel M, Faulhaber J, Schiffelholz T, Mathias S, Deisz RA. Muscimol and midazolam do not potentiate each other's effects on sleep EEG in the rat. J Neurophysiol 1997;77:1624-9.
4. A agonist THIP produces slow wave sleep and reduces spindling activity in NREM sleep in humans. Psychopharmacology 1997;130:285-91.
5. Borbély AA, Neuhaus HU. Sleep-deprivation: effects on sleep and EEG in the rat. J Comp Physiol 1979;133:71-87.
6. Tobler I, Borbély AA. Sleep EEG in the rat as a function of prior waking. Electroencephalogr Clin Neurophysiol 1986;64: 74-6.
7. Lancel M, Kerkhof GA. Effects of repeated sleep deprivation in the dark- or light-period on sleep in rats. Physiol Behav 1989; 45:289-97.
8. Franken P, Dijk DJ, Tobler I, Borbély AA. Sleep deprivation in rats: effects on EEG power spectra, vigilance states, and cortical temperature. Am J Physiol 1991;261:R198-208.
9. Franken P, Tobler I, Borbély AA. Effects of 12-h sleep deprivation and of 12-h cold exposure on sleep regulation and cortical temperature in the rat. Physiol Behav 1993;53:885-94.
10. Borbély AA, Baumann F, Brandeis D, Strauch I, Lehmann D. Sleep deprivation: effect on sleep stages and EEG power density in man. Electroencephalogr Clin Neurophysiol 1981;51:483-93.
11. Dijk DJ, Czeisler CA. Body temperature is elevated during the rebound of slow-wave sleep following 40-h of sleep deprivation on a constant routine. J Sleep Res 1993;2:117-20.
12. Dijk DJ, Hayes B, Czeisler CA. Dynamics of electroencephalographic sleep spindles and slow wave activity in men: effect of sleep deprivation. Brain Res 1993;626:190-9.
13. Dijk DJ, Brunner DP, Beersma DGM, Borbély AA. Electroencephalogram power density and slow wave sleep as a function of prior waking and circadian phase. Sleep 1990;13:430-40.
14. Dijk DJ, Brunner DP, Borbély AA. EEG power density during recovery sleep in the morning. Electroencephalogr Clin Neurophysiol 1991;78:203-14.
15. Gandolfo G, Scherschlicht R, Gottesmann C. Benzodiazepines promote the intermediate stage at the expense of paradoxical sleep in the rat. Pharmacol Biochem Behav 1994;49:921-7.
16. Neckelmann D, Ursin R. Sleep stages and EEG power spectrum in relation to acoustical stimulus arousal threshold in the rat. Sleep 1993;16:464-77.
17. Marescaux C, Micheletti G, Vergnes M, Rumbach L, Warter JM. Diazepam antagonizes GABAmimetics in rats with spontaneous petit mal-like epilepsy. Eur J Pharmacol 1985;113:19-24.
18. Lancel M, Mathias S, Faulhaber J, Schiffelholz T. Effect of interleukin-1β on EEG power density during sleep depends on circadian phase. Am J Physiol 1996;270:R830-7.
19. Mendelson WB, Martin JV. Effects of muscimol and flurazepam on the sleep EEG in the rat. Life Sci 1990;47:P99-101.
20. Liu Z, Vergnes M, Depaulis A, Marescaux C. Evidence for a critical role of GABAergic transmission within the thalamus in the genesis and control of absence seizures in the rat. Brain Res 1991;545:1-7.
21. Dugovic C, Leysen JE, Janssen PF, Wauquier A. The light-dark cycle modulates the effects of ritanserin on sleep-wakefulness patterns in the rat. Pharmacol Biochem Behav 1989;34:533-7.
22. Mendelson WB, Gillin JC, Dawson SD, Lewy AJ, Wyatt RJ. Effects of melatonin and propranolol on sleep of the rat. Brain Res 1980;201:240-4.
23. Opp MR, Obál F Jr, Krueger JM. Interleukin-1 alters rat sleep: temporal and dose-related effects. Am J Physiol 1991;260:R52-8.
24. Mistlberger RE, Bergmann BM, Waldenar W, Rechtschaffen A. Recovery sleep following sleep deprivation in intact and suprachiasmatic nuclei-lesioned rats. Sleep 1983;6:217-33.
25. Lancel M, van Riezen H, Glatt A. Enhanced slow-wave activity within NREM sleep in the cortical and subcortical EEG of the cat after sleep deprivation. Sleep 1992;15:102-18.
26. Trachsel L, Tobler I, Borbély AA. Effect of sleep deprivation on EEG slow wave activity within non-REM sleep episodes in the rat. Electroencephalogr Clin Neurophysiol 1989;73:167-71.
27. Steiger A, Guldner J, Lauer CJ, Meschenmoser C, Pollmächer T, Holsboer F. Flumazenil exerts intrinsic activity on sleep EEG and nocturnal hormone secretion in normal controls. Psychopharmacology 1994;113:334-8.
28. Iversen LL, Kelly JS. Uptake and metabolism of γ-aminobutyric acid by neurons and glial cells. Biochem Pharmacol 1975;24: 933-8.