Autoantibodies from patients with primary biliary cirrhosis recognize a region within the nucleoplasmic domain of inner nuclear membrane protein LBR

Hepatology

Volumn 23, Issue 1, 1996, Pages 57-61

  Lin, Feng ^a   Noyer, Charles M ^b   Ye, Qian ^a   Courvalin, Jean Claude ^c   Worman, Howard J ^a  

^a The New York Presbyterian Hospital   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c INSTITUT JACQUES MONOD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BIOCHEMICAL MARKER; MEMBRANE PROTEIN;

AMINO TERMINAL SEQUENCE; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS MEMBRANE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INTERMEDIATE FILAMENT; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

EID: 0030034034     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.1996.v23.pm0008550049     Document Type: Article

References (25)

1. Sherlock S, Scheuer P. The presentation and diagnosis of 100 patients with primary biliary cirrhosis. N Engl J Med 1973;289:674-678.
2. Schaffner F. Primary biliary cirrhosis. Clin Gastroenterol 1975;4:351-366.
3. Kaplan MM. Primary biliary cirrhosis. N Engl J Med 1987;316:521-528.
4. Gershwin ME, Mackay IR. Primary biliary cirrhosis: paradigm or paradox for autoimmunity. Gastroenterology 1991;100:822-833.
5. Coppel RL, McNeilage LJ, Surh CD, Van de Water J, Spithill TW, Whittingham S, Gershwin ME. Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase. Proc Natl Acad Sci USA 1988;85:7317-7321.
6. Fussey SPM, Guest JR, James OFW, Bassendine MF, Yeaman SJ. Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis. Proc Natl Acad Sci USA 1988;85:8654-8658.
7. Surh CD, Danner DJ, Ahmed A, Coppel RL, Mackay IR, Dickson ER, Gershwin ME. Reactivity of primary biliary cirrhosis sera with a human fetal liver cDNA line of branched chain alpha-keto acid dehydrogenase dihydrolipoamide acetyltransferase, the 52 kD mitochondrial antigen. HEPATOLOGY 1989;9:63-68.
8. Worman HJ, Courvalin J-C. Autoantibodies against nuclear envelope proteins in liver disease. HEPATOLOGY 1991;14:1269-1279.
9. Courvalin J-C, Lassoued K, Bartnik E, Blobel G, Wozniak RW. The 210 kilodalton nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore. J Clin Invest 1990;86:279-285.
10. Lassoued K, Brenard R, Degos F, Courvalin J-C, André C, Danon R, Brouet J-C, et al. Antinuclear antibodies directed to a 200 kD polypeptide of the nuclear envelope in primary biliary cirrhosis: a clinical and immunological study of a series of 150 patients with primary biliary cirrhosis. Gastroenterology 1990;99:181-186.
11. Nickowitz RE, Wozniak RW, Schaffner F, Worman HJ. Autoantibodies against integral proteins of the nuclear envelope in patients with primary biliary cirrhosis. Gastroenterology 1994;106:193-199.
12. Courvalin J-C, Lassoued K, Worman HJ, Blobel G. Identification and characterization of autoantibodies against the nuclear envelope lamin B receptor from patients with primary biliary cirrhosis. J Exp Med 1990;172:961-967.
13. Steinman L. Escape from "horro autotoxicus": pathogenesis and treatment of autoimmune disease. Cell 1995;80:7-10.
14. Van de Water J, Gershwin ME, Leung P, Ansari A, Coppel RL. The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase. J Exp Med 1988;167:1791-1803.
15. Surh CD, Coppel R, Gershwin ME. Structural requirement for autoreactivity on human pyruvate dehydrogenase-E2, the major autoantigen of primary biliary cirrhosis. Implications for a conformational epitope. J Immunol 1990;144:3367-3374.
16. Cha S, Leung PS, Coppel RL, Van de Water J, Ansari AA, Gershwin ME. Heterogeneity of combinatorial human autoantibodies against PDC-E2 and biliary epithelial cells in patients with primary biliary cirrhosis. HEPATOLOGY 1994;20:574-583.
17. Cha S, Leung PS, Gershwin ME, Fletcher MP, Ansari AA, Coppel RL. Combinatorial autoantibodies to dihydrolipoamide acetyltransferase, the major autoantigen of primary biliary cirrhosis. Proc Natl Acad Sci U S A 1993;90:2527-2531.
18. Van de Water J, Turchany J, Leung PS, Lake J, Munoz S, Surh CD, Coppel R, et al. Molecular mimicry in primary biliary cirrhosis: evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2. J Clin Invest 1993;91:2653-2664.
19. Tsuneyama K, Van de Water J, Nakanuma Y, Cha S, Ansari A, Coppel R, Gershwin ME. Human combinatorial autoantibodies and mouse monoclonal antibodies to PDC-E2 produce abnormal apical staining of salivary glands in patients with coexistent primary biliary cirrhosis and Sjogren's syndrome. HEPATOLOGY 1994;20:893-898.
20. Nickowitz RE, Worman HJ. Autoantibodies from patients with primary biliary cirrhosis recognize a restricted region within the cytoplasmic tail of nuclear pore membrane glycoprotein gp210. J Exp Med 1993;178:2237-2242.
21. Tartakovsky F, Worman HJ. Detection of gp210 autoantibodies in primary biliary cirrhosis using a recombinant protein containing the predominant autoepitope. HEPATOLOGY 1995;21:495-500.
22. Chou CH, Reeves WH. Recognition of multiple epitopes in the coiled-coil domain of lamin B by human autoantibodies. Mol Immunol 1992;29:1055-1064.
23. Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, Mullis KB, et al. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 1987;239:487-491.
24. Ye Q, Worman HJ. Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane. J Biol Chem 1994;269:11306-11311.
25. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A 1977;74:5463-5467.