Mitochondrial uncoupling protein as a target of pharmacotherapy for obesity

Folia Pharmacologica Japonica

Volumn 118, Issue 5, 2001, Pages 327-333

  Saito, M ^a   Ohashi, A ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Fatty acids; Metabolic thermogenesis; Sympathetic nerves; Uncoupling protein

Indexed keywords

4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID METHYL ESTER; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; ADENYLATE CYCLASE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FATTY ACID; ISOPRENALINE; NORADRENALIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; RETINOID X RECEPTOR; SALBUTAMOL; THYROID HORMONE RECEPTOR; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

BODY FAT; BROWN ADIPOSE TISSUE; COLD SENSATION; DRUG MECHANISM; DRUG TARGETING; HYPERPHAGIA; INFECTION RESISTANCE; KNOCKOUT MOUSE; MITOCHONDRION; OBESITY; OXIDATIVE PHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FAMILY; REVIEW; THERMOGENESIS;

ADRENERGIC AGONISTS; CARRIER PROTEINS; DRUG DESIGN; HUMANS; ION CHANNELS; MEMBRANE PROTEINS; MITOCHONDRIAL PROTEINS; OBESITY;

EID: 0035195718     PISSN: 00155691     EISSN: None     Source Type: Journal    
DOI: 10.1254/fpj.118.327     Document Type: Review

References (21)

1. The uncoupling protein homologues: UCP1, UCP2, UCP 3, StUCP and At UCP
2. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
3. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
4. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
5. Uncoupling protein-2: A nobel gene linked to obesity and hyperinsulinemia
6. Uncoupling protein 3: A new member of the mitochondrial carrier family with tissue-specific expression
7. The uncoupling proteins, a review
8. Energy metabolism in uncoupling protein 3 gene knockout mice
9. Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3
10. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
11. Towards a molecular understanding of adaptive thermogenesis
12. Up-regulation of uncoupling protein 3 by thyroid hormone, peroxisome proliferator-activated receptor ligands and 9-cis retinoic acid in L 6 myotubes
13. Up-regulation of uncoupling proteins by β-adrenergic stimulation in L6 myotubes
14. 3-adrenergic agonist
15. 3-adrenergic agonist
16. 3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism
17. 3-adrenergic receptor is required for MAP kinase activation
18. 3-Adrenergic agonist up-regulates uncoupling proteins 2 and 3 in skeletal muscle of the mouse
19. Coenzyme Q is an obligatory cofactor for uncoupling protein function
20. + transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)
21. Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2