The thrombin inhibitor, hirudin, attenuates lipopolysaccharide-induced liver injury in the rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 278, Issue 1, 1996, Pages 378-383

  Pearson, Julia M ^a,b   Schultze, A Eric ^c   Schwartz, Kenneth A ^a   Scott, Michael A ^a   Davis, John M ^a   Roth, Robert A ^a,b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; FIBRINOGEN; LEPIRUDIN; THROMBIN; THROMBIN INHIBITOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FIBRINOGEN BLOOD LEVEL; LIVER INJURY; LIVER NECROSIS; NEUTROPHIL; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTE;

ANIMALS; BLOOD PLATELETS; DISEASE MODELS, ANIMAL; FEMALE; HIRUDINS; LIPOPOLYSACCHARIDES; LIVER; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030435119     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. BAR-SHAVIT, R., KAHN, A., FENTON, J. W. II. AND WILNER, G. D.: Receptormediated chemotactic response of a macrophage cell line (J774) to thrombin. Lab. Invest. 49: 702-707, 1983a.
2. BAR-SHAVIT, R., KAHN, A., FENTON, J. W. II. AND WILNKR, G. D.: Chemotactic response of monocytes to thrombin. J. Cell. Biol. 96: 282-285, 1983b.
3. BECKER, M., MENGER, M. D. AND LEHR, H.: Heparin-released Superoxide dismutase inhibits postischemic leukocyte adhesion to venular endothelium. Am. J. Physiol. 267: H925-H930, 1994.
4. BIZIOS, R., LAI, L., FENTON, J. W. II. AND MALIK, A. B.: Thrombin-induced chemotaxis and aggregation of neutrophils. J. Cell. Physiol. 128: 485-490, 1986.
5. BROWN, A. P., NG, H., JEAN, P. A., GANEY, P. E. AND ROTH, R. A.: Kupffer cell inactivation protects against lipopolysaccharide-induced hepatic injury despite neutrophil accumulation and tumor necrosis factor-α (TNF-α) release (Abstract). Toxicologist 15: 727, 1995.
6. COHEN, W. M., WU, H., LEATHERSTONE, G. L., JENZANO, J. W. AND LUNDBLAD, R. L.: Linkage between blood coagulation and inflammation: Stimulation of neutrophil tissue kallikrein by thrombin. Biochem. Biophys. Res. Commun. 176: 315-320, 1991.
7. DEMICHELE, M. A. A. AND MINNEAR, F. L.: Modulation of vascular endothelial permeability by thrombin. Semin. Thrombos. Hemostas. 18: 287-295, 1992.
8. DRAKE, W. T. AND ISSEKUTZ, A. C.: A role for α-thrombin in polymorphonuclear leukocyte recruitment during inflammation. Semin. Thrombos. Hemostas. 18: 333-340, 1992.
9. 2 by heparin. Eur. J. Biochem. 221: 481-490, 1994.
10. 1, local anesthetics and a serine-protease inhibitor. Prostaglandins 14: 1075-1093, 1977.
11. FENTON, J. W. II: Thrombin interactions with hirudin. Semin. Thrombos. Hemostas. 15: 265-287, 1989.
12. FENTON, J. W. II., VILLANUEVA, G. B., OFOSU, F. A. AND MARGANORE, J. M.: Thrombin inhibition by hirudin: How hirudin inhibits thrombin. Haemostasia 21: Suppl. 1, 27-31, 1991.
13. FERRER-LOPEZ, P., RENESTO, P., PREVOST, M., GOUNON, P. AND CHIGNARD, M.: Heparin inhibits neutrophil-induced platelet activation via cathepsin G. J. Lab. Clin. Med. 119: 231-239, 1982.
14. HEWETT, J. A. AND ROTH, R. A.: The coagulation system, but not circulating fibrinogen, contributes to liver injury in rats exposed to lipopolysaccharide from gram-negative bacteria. J. Pharmacol. Exp. Ther. 272: 53-62, 1995.
15. HEWETT, J. A., SCHULTZE, A. E., VAN CISE, S. AND ROTH, R. A.: Neutrophil depletion protects against liver injury from bacterial endotoxin. Lab. Invest. 66: 347-361, 1992.
16. JONES, A. AND GECZY, C. L.: Thrombin and factor Xa enhance the production of interleukin-1. Immunology 71: 236-241, 1990.
17. MARGARETTEN, W., McKAY, D. G. AND PHILLIPS, L. L.: The effect of heparin on endotoxin shock in the rat. Am. J. Pathol. 51: 61-68, 1967.
18. MARKWARDT, F.: Development of hirudin as an antithrombotic agent. Semin. Thrombos. Hemostas. 15: 269-282, 1989.
19. OLSON, S. T. AND BJORK, I.: Regulation of thrombin activity by antithrombin and heparin. Semin. Thrombos. Hemostas. 20: 373-409, 1994.
20. PEARSON, J. M., SCHULTZE, A. E., JEAN, P. A. AND ROTH, R. A.: Platelet participation in liver injury from gram-negative bacterial lipopolysaccharide in the rat. Shock 4: 178-186, 1995.
21. PEARSON, J. M. AND ROTH, R. A.: Hepatic platelet sequestration after lipopolysaccharide administration is not altered by heparin (Abstract). Toxicologist 15: 1694, 1995.
22. PODJARNY, E., RATHAUS, M., POMERANZ, A., SHAPIRA, J. AND BERNHEIM, J.: Thrombin inhibits the synthesis of prostanoids by isolated glomeruli and peritoneal macrophages in rats. Nephron 53: 50-53, 1989.
23. SHIBAYAMA, Y.: Sinusoidal circulatory disturbance by microthrombosis as a cause of endotoxin-induced hepatic injury. J. Pathol. 151: 315-321, 1987.
24. SHIBAYAMA, Y., HASHIMOTO, K. AND NAKATA, K.: Relation of the reticuloendothelial function to endotoxin hepatotoxicity. Exp. Pathol. 43: 173-179, 1991.
25. TALBOT, M.: Biology of recombinant hirudin (CGP 39393): A new prospect in the treatment of thrombosis. Semin. Thrombos. Hemostas. 15: 293-301, 1989.
26. WEBB, L. M. C., EHRENGRUBER, M. U., CLARK-LEWIS, I., BAGGIOLINI, M. AND ROT, A.: Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8. Proc. Natl. Acad. Sci. U.S.A. 90: 7158-7162, 1993.
27. WHITE, S. M. AND ROTH, R. A.: Pulmonary platelet sequestration is increased following monocrotaline pyrrole treatment of rats. Toxicol. Appl. Pharmacol. 96: 465-475, 1988.
28. WISE, J. C., COOK, J. A., HALUSHJA, P. V. AND KNAPP, D. R.: Protective effects of thromboxane synthase inhibitors in rats in endotoxic shock. Circ. Res. 46: 854-859, 1980.