Impairment of myocardial contractility by anticancer anthracyclines: Role of secondary alcohol metabolites and evidence of reduced toxicity by a novel disaccharide analogue

British Journal of Pharmacology

Volumn 134, Issue 6, 2001, Pages 1271-1278

  Minotti, Giorgio ^a   Parlani, Massimo ^b   Salvatorelli, Emanuela ^a   Menna, Pierantonio ^a   Cipollone, Amalia ^b   Animati, Fabio ^b   Maggi, Carlo A ^b   Manzini, Stefano ^b  

^a UNIVERSITY OF CHIETI   (Italy)

^b Menarini Ricerche SpA   (Italy)

Author keywords

Cardiotoxicity; Doxorubicin; Epirubicin; MEN 10755; Secondary alcohol metabolites

Indexed keywords

ALCOHOL DERIVATIVE; ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; CARBONYL DERIVATIVE; DISACCHARIDE; DOXORUBICIN; EPIRUBICIN; SABARUBICIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CELL LEVEL; CONTROLLED STUDY; CORRELATION FUNCTION; DRUG METABOLISM; DRUG UPTAKE; ESTERIFICATION; HEART MUSCLE; HEART MUSCLE CONTRACTILITY; HUMAN; HUMAN TISSUE; INOTROPISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION;

EID: 0035192387     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704369     Document Type: Article

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