Effect of MEN 10755, a new disaccharide analogue of doxorubicin, on sarcoplasmic reticulum Ca2+ handling and contractile function in rat heart

British Journal of Pharmacology

Volumn 131, Issue 2, 2000, Pages 342-348

  Zucchi, R ^a   Yu, G ^a   Ghelardoni, S ^a   Ronca, F ^a   Ronca Testoni, S ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Anthraquinones; Calcium; Doxorubicin; Epirubicin; Heart; MEN 10755; Ryanodine receptor; Sarcoplasmic reticulum

Indexed keywords

7 O [2,6 DIDEOXY 4 O (2,3,6 TRIDEOXY 3 AMINO ALPHA LEVO HEXOPYRANOSYL) ALPHA LEVO HEXOPYRANOSYL] 4 DEMETHOXY 13 DIHYDRO 14 HYDROXYDAUNOMYCINONE; 7 O [2,6 DIDEOXY 4 O (2,3,6 TRIDEOXY 3 AMINO ALPHA LEVO HEXOPYRANOSYL) ALPHA LEVO HEXOPYRANOSYL] 4 DEMETHOXY 14 HYDROXYDAUNOMYCINONE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ANTHRAQUINONE DERIVATIVE; CALCIUM; DISACCHARIDE; DOXORUBICIN; DOXORUBICIN DERIVATIVE; DOXORUBICINOL; EPIRUBICIN; EPIRUBICINA; MEN 11383; RYANODINE; RYANODINE RECEPTOR; SABARUBICIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CARDIOTOXICITY; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; HEART MUSCLE CONTRACTILITY; HEMODYNAMICS; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOPLASMIC RETICULUM;

EID: 0033770084     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703575     Document Type: Article

References (40)

1. Mechanism of anthraquinone-induced calcium release from skeletal muscle sarcoplasmic reticulum
2. Sarcoplasmic reticulum genes are selectively down-regulated in cardiomyopathy produced by doxorubicin in rabbits
3. Doxorubicin disaccharide analogue: Apoptosis-related improvement of efficacy in vivo
4. Anthracycline-induced tension in permeabilized cardiac fibres: Evidence for the activation of the calcium release channel of the sarcoplasmic reticulum
5. The major metabolite of doxorubicin is a potent inhibitor of membrane-associated ion pumps
6. Early and delayed clinical cardiotoxicity of doxorubicin
7. Trypsin digestion of junctional sarcoplasmic reticlum vesicles
8. Comparison of doxorubicin- and MEN 10755-induced long-term progressive cardiotoxicity in the rat
9. Doxorubicin cardiomyopathy is associated with a decrease in calcium release channel of the sarcoplasmic reticulum in a chronic rabbit model
10. Doxorubicin-induced cardiac toxicity
11. A rapid-filtration technique for membrane fragments or immobilized enzymes: Measurements of substrate binding or ion fluxes with a few-millisecond time resolution
12. Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells
13. Mechanism of action of ryanodine on cardiac sarcoplasmic reticulum
14. Site-selective modification of hyperreactive cysteines off ryanodine receptor complex by quinones
15. Doxorubicin: Mechanisms of cardiodepressant actions in guinea pigs
16. Inhibition of calcium accumulation by the sarcoplasmic reticulum: A putative mechanism for the cardiotoxicity of adriamycin
17. Doxorubicin cardiotoxicity: Contractile changes after long-term treatment in the rat
18. Doxorubicin-induced changes in intracellular Ca2+ transients observed in cardiac myocytes isolated from guinea-pig heart
19. Doxorubicin-induced calcium release from cardiac sarcoplasmic reticulum vesicles
20. Alterations of intracellular calcium homeostasis and myocardial energetics in acute adriamycin-induced heart failure
21. Doxorubicin cardiotoxicity: Diastolic cardiac myocyte dysfunction as a result of impaired calcium handling in isolated cardiac myocytes
22. 2+ release from skeletal sarcoplasmic reticulum
23. Late cardiotoxicity following anthracycline therapy for childhood cancer
24. Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol
25. Biphasic effects of doxorubicin on the calcium release channel from sarcoplasmic reticulum of cardiac muscle
26. Analysis of negative inotropic actions of anthracyclins (doxorubicin, epirubicin and MEN 10755) in rat isolated rat ventricles
27. 2+ release channel from rat cardiac sarcoplasmic reticulum: Possible receptor-mediated mechanism of doxorubicin cardiomyopathy
28. Etiology of sarcoplasmic reticulum calcium release channel lesions in doxorubicin-induced cardiomyopathy
29. Improved efficacy and enlarged spectrum of activity of a novel anthracycline disaccharide analogue of doxorubicin against human tumor xenografts
30. Anthracyclines and the heart
31. Measurements of cation transport with metallochromic indicators
32. 2+ loading and inotropic effects of doxorubicin in atrial muscle preparations isolated from rat or giunea-pig hearts
33. 2+ release from skeletal and cardiac muscle sarcoplasmic reticulum
34. Effects of doxorubicin on excitation-contraction coupling in guinea pig ventricular myocardium
35. Doxorubicin-induced calcium release from terminal cisternae of skeletal muscle
36. + channel/ryanodine receptor: Modulation by endogenous effectors, drugs and disease states
37. 2+ channels
38. Interaction between gallopamil and cardiac ryanodine receptors
39. 2+ channels. A possible mechanism of ischemic preconditioning