메뉴 건너뛰기




Volumn 98, Issue 3, 1996, Pages 650-661

Paradoxical inhibition of cardiac lipid peroxidation in cancer patients treated with doxorubicin: Pharmacologic and molecular reappraisal of anthracycline cardiotoxicity

Author keywords

cardiotoxicity; doxorubicin; free radicals; iron; lipid peroxidation

Indexed keywords

DOXORUBICIN; ISOFERRITIN;

EID: 0029910238     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118836     Document Type: Article
Times cited : (68)

References (81)
  • 1
    • 0016797157 scopus 로고
    • Adriamycin (NSC 123127) cardiomyopathy - An overview with determination of risk factors
    • Minow, R.A., R.S. Benjamin, and J.A. Gottlieb. 1975. Adriamycin (NSC 123127) cardiomyopathy - an overview with determination of risk factors. Cancer Chemother. Rep. 6:198-201.
    • (1975) Cancer Chemother. Rep. , vol.6 , pp. 198-201
    • Minow, R.A.1    Benjamin, R.S.2    Gottlieb, J.A.3
  • 2
    • 0026029483 scopus 로고
    • 2: Evidence for enhanced toxicity with multiagent chemotherapy
    • 2: evidence for enhanced toxicity with multiagent chemotherapy. Am. J. Hematol. 36:217-218.
    • (1991) Am. J. Hematol. , vol.36 , pp. 217-218
    • Watts, R.G.1
  • 3
    • 0024592332 scopus 로고
    • Free radical formation by antitumor quinones
    • Powis, G. 1989. Free radical formation by antitumor quinones. Free Radic. Biol. & Med. 6:63-101.
    • (1989) Free Radic. Biol. & Med. , vol.6 , pp. 63-101
    • Powis, G.1
  • 4
    • 0025051505 scopus 로고
    • Doxorubicin cardiotoxicity: Analysis of prevailing hypotheses
    • Olson, R.D., and P.S. Mushlin. 1990. Doxorubicin cardiotoxicity: analysis of prevailing hypotheses. FASEB J. 4:3076-3086.
    • (1990) FASEB J. , vol.4 , pp. 3076-3086
    • Olson, R.D.1    Mushlin, P.S.2
  • 5
    • 0026078494 scopus 로고
    • Doxorubicin-induced cardiotoxicity
    • Doroshow, J.H. 1991. Doxorubicin-induced cardiotoxicity. N. Engl. J. Mol. 324:843-845.
    • (1991) N. Engl. J. Mol. , vol.324 , pp. 843-845
    • Doroshow, J.H.1
  • 6
    • 0026760865 scopus 로고
    • Manganese deficiency and transcriptional regulation of mitochondrial superoxide dismutase
    • Borrello, S., E. De Leo, H. Wohlrab, and T. Galeotti. 1992. Manganese deficiency and transcriptional regulation of mitochondrial superoxide dismutase. FEBS Lett. 3:249-254.
    • (1992) FEBS Lett. , vol.3 , pp. 249-254
    • Borrello, S.1    De Leo, E.2    Wohlrab, H.3    Galeotti, T.4
  • 8
    • 0027502430 scopus 로고
    • Sources and role of iron in lipid peroxidation
    • Minotti, G. 1993. Sources and role of iron in lipid peroxidation. Chem. Res. Toxicol. 6:134-146.
    • (1993) Chem. Res. Toxicol. , vol.6 , pp. 134-146
    • Minotti, G.1
  • 9
    • 0020875630 scopus 로고
    • Ferritin: Structure, function, and regulation
    • B.C. Theil, G.L. Eichorn, and L. Marzili, editors. Elsevier Science Publishing. Co., Inc., New York
    • Theil, E.C. 1983. Ferritin: structure, function, and regulation. In Iron Binding Proteins Without Cofactors or Sulfur Clusters. B.C. Theil, G.L. Eichorn, and L. Marzili, editors. Elsevier Science Publishing. Co., Inc., New York. 1-38.
    • (1983) Iron Binding Proteins Without Cofactors or Sulfur Clusters , pp. 1-38
    • Theil, E.C.1
  • 10
    • 0026710009 scopus 로고
    • The role of iron in oxygen-mediated toxicities
    • Ryan, T.P., and S.D. Aust. 1992. The role of iron in oxygen-mediated toxicities. Crit. Rev. Toxicol. 22:119-141.
    • (1992) Crit. Rev. Toxicol. , vol.22 , pp. 119-141
    • Ryan, T.P.1    Aust, S.D.2
  • 11
    • 0023726412 scopus 로고
    • Adriamycin-induced free radical formation in the perfused rat heart: Implications for cardiotoxicity
    • Rajagopalan, S., P.M. Politi, B.K. Sinha, and C.E. Myers. 1988. Adriamycin-induced free radical formation in the perfused rat heart: implications for cardiotoxicity. Cancer Res. 48:4766-4769.
    • (1988) Cancer Res. , vol.48 , pp. 4766-4769
    • Rajagopalan, S.1    Politi, P.M.2    Sinha, B.K.3    Myers, C.E.4
  • 12
    • 0028323537 scopus 로고
    • Effect of vitamin A administration on resistance of rat heart against doxorubicin-induced cardiotoxicity and lethality
    • Tesoriere, L., M. Ciaccio, M. Valenza, A. Bongiorno, E. Maresi, R. Albiero, and M.A. Livrea. 1994. Effect of vitamin A administration on resistance of rat heart against doxorubicin-induced cardiotoxicity and lethality. J. Pharmacol. Exp. Ther. 269:430-436.
    • (1994) J. Pharmacol. Exp. Ther. , vol.269 , pp. 430-436
    • Tesoriere, L.1    Ciaccio, M.2    Valenza, M.3    Bongiorno, A.4    Maresi, E.5    Albiero, R.6    Livrea, M.A.7
  • 13
    • 0028888378 scopus 로고
    • Probucol protects against adriamycin cardiomyopathy without interfering with its antitumor effect
    • Siveski-Iliskovic, N., M. Hill, D.A. Chow, and P.K. Singal. 1995. Probucol protects against adriamycin cardiomyopathy without interfering with its antitumor effect. Circulation. 91:10-15.
    • (1995) Circulation , vol.91 , pp. 10-15
    • Siveski-Iliskovic, N.1    Hill, M.2    Chow, D.A.3    Singal, P.K.4
  • 15
    • 0026498952 scopus 로고
    • Copper and selenium deficiencies do not enhance the cardiotoxicity in rats due to chronic doxorubicin treatment
    • Fischer, J.C., R.L. Tackett, E.W. Howerth, and M.A. Johnson. 1992. Copper and selenium deficiencies do not enhance the cardiotoxicity in rats due to chronic doxorubicin treatment. J. Nutr. 122:2128-2137.
    • (1992) J. Nutr. , vol.122 , pp. 2128-2137
    • Fischer, J.C.1    Tackett, R.L.2    Howerth, E.W.3    Johnson, M.A.4
  • 16
    • 0027231126 scopus 로고
    • Accumulation of malondialdehyde in mouse heart following acute dosing with adriamycin is strain specific and unaffected by cardiac catalase status
    • Baird, M.B., J.L. Hough, and G.T. Sfeir. 1993. Accumulation of malondialdehyde in mouse heart following acute dosing with adriamycin is strain specific and unaffected by cardiac catalase status. Res. Commun. Chem. Pathol. Pharmacol. 80:363-366.
    • (1993) Res. Commun. Chem. Pathol. Pharmacol. , vol.80 , pp. 363-366
    • Baird, M.B.1    Hough, J.L.2    Sfeir, G.T.3
  • 17
    • 0027207013 scopus 로고
    • In vivo and in vitro mitochondrial membrane damages induced in mice by adriamycin and derivatives
    • Pract, M., and J.M. Ruysschaert. 1993. In vivo and in vitro mitochondrial membrane damages induced in mice by adriamycin and derivatives. Biochim. Biophys. Acta. 1149:79-85.
    • (1993) Biochim. Biophys. Acta , vol.1149 , pp. 79-85
    • Pract, M.1    Ruysschaert, J.M.2
  • 18
    • 0021141362 scopus 로고
    • The Karnofsky performance status scale: An examination of its reliability and validity in a research setting
    • Mor, V., L. Laliberte, J.N. Morris, and M. Wiemann. 1984. The Karnofsky performance status scale: an examination of its reliability and validity in a research setting. Cancer. 53:2002-2007.
    • (1984) Cancer , vol.53 , pp. 2002-2007
    • Mor, V.1    Laliberte, L.2    Morris, J.N.3    Wiemann, M.4
  • 19
    • 0022444914 scopus 로고
    • The relationship between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis
    • Ledwozyw, A., J. Michalak, A. Stepien, and A. Kadziolka. 1986. The relationship between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis. Clin. Chim. Acta. 155:275-284.
    • (1986) Clin. Chim. Acta , vol.155 , pp. 275-284
    • Ledwozyw, A.1    Michalak, J.2    Stepien, A.3    Kadziolka, A.4
  • 20
    • 0028018197 scopus 로고
    • Vitamin E supplementation suppresses indexes of lipid peroxidation and platelet counts in blood of smokers and nonsmokers but plasma lipoprotein concentrations remain unchanged
    • Brown, K.M., P.C. Morrice, and G. Duthie. 1994. Vitamin E supplementation suppresses indexes of lipid peroxidation and platelet counts in blood of smokers and nonsmokers but plasma lipoprotein concentrations remain unchanged. Am. J. Clin. Nutr. 60:383-387.
    • (1994) Am. J. Clin. Nutr. , vol.60 , pp. 383-387
    • Brown, K.M.1    Morrice, P.C.2    Duthie, G.3
  • 22
    • 2442713397 scopus 로고
    • Catheter replacement of the needle in percutaneous arteriography: A new technique
    • Seldinger, S. 1953. Catheter replacement of the needle in percutaneous arteriography: a new technique. Acta Radiol. 39:368-376.
    • (1953) Acta Radiol. , vol.39 , pp. 368-376
    • Seldinger, S.1
  • 23
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch, J.M., M. Lees, and H.S. Stanley. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509.
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-509
    • Folch, J.M.1    Lees, M.2    Stanley, H.S.3
  • 25
    • 0024430411 scopus 로고
    • Conjugated dienes detected in tissue lipid extracts by second-derivative spectrophotometry
    • Corongiu, F.P., S. Banni, and M. A. Dessi'. 1989. Conjugated dienes detected in tissue lipid extracts by second-derivative spectrophotometry. Free Radical Biol. & Med. 7:183-186.
    • (1989) Free Radical Biol. & Med. , vol.7 , pp. 183-186
    • Corongiu, F.P.1    Banni, S.2    Dessi', M.A.3
  • 27
    • 10244243505 scopus 로고
    • Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxides in low density lipoprotein
    • Jiang, Z.Y., J.V. Hunt, and S.P. Wolff. 1992. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxides in low density lipoprotein. Anal. Biochem. 26:853-856.
    • (1992) Anal. Biochem. , vol.26 , pp. 853-856
    • Jiang, Z.Y.1    Hunt, J.V.2    Wolff, S.P.3
  • 28
    • 0028167732 scopus 로고
    • Measurement of plasma hydroperoxide concentrations by the ferrous-xylenol orange assay in conjunction with triphenylphosphine
    • Nourooz-Zadeh, J., J. Tajaddini-Sarmadi, and S.P. Wolff. 1994. Measurement of plasma hydroperoxide concentrations by the ferrous-xylenol orange assay in conjunction with triphenylphosphine. Anal. Biochem. 220:403-409.
    • (1994) Anal. Biochem. , vol.220 , pp. 403-409
    • Nourooz-Zadeh, J.1    Tajaddini-Sarmadi, J.2    Wolff, S.P.3
  • 29
    • 0025778781 scopus 로고
    • A simple assay for lipid hydroperoxides based on triphenylphosphine oxidation and high performance liquid Chromatography
    • Nakamura, T., and H. Maeda. 1991. A simple assay for lipid hydroperoxides based on triphenylphosphine oxidation and high performance liquid Chromatography. Lipids. 26:765-768.
    • (1991) Lipids , vol.26 , pp. 765-768
    • Nakamura, T.1    Maeda, H.2
  • 31
    • 0025095542 scopus 로고
    • Transition metals as catalysts of "autoxidation" reactions
    • Miller, D.M., G.R. Buettner, and S.D. Aust. 1990. Transition metals as catalysts of "autoxidation" reactions. Free Radic. Biol. & Med. 8:95-108.
    • (1990) Free Radic. Biol. & Med. , vol.8 , pp. 95-108
    • Miller, D.M.1    Buettner, G.R.2    Aust, S.D.3
  • 32
    • 0026597915 scopus 로고
    • Redox cycling of iron and lipid peroxidation
    • Minotti, G., and S.D. Aust. 1992. Redox cycling of iron and lipid peroxidation. Lipids. 27:219-226.
    • (1992) Lipids , vol.27 , pp. 219-226
    • Minotti, G.1    Aust, S.D.2
  • 33
    • 0023154707 scopus 로고
    • The requirement for Fe(III) in the initiation of lipid peroxidalion by Fe(II) and hydrogen peroxide
    • Minotti, G., and S.D. Aust. 1987. The requirement for Fe(III) in the initiation of lipid peroxidalion by Fe(II) and hydrogen peroxide. J. Biol. Chem. 262:1098-1104.
    • (1987) J. Biol. Chem. , vol.262 , pp. 1098-1104
    • Minotti, G.1    Aust, S.D.2
  • 34
    • 0026472376 scopus 로고
    • Iron metabolism: New perspectives in view
    • Crichton, R.R., and R.J. Ward. 1992. Iron metabolism: new perspectives in view. Biochemistry. 31:11255-11264.
    • (1992) Biochemistry , vol.31 , pp. 11255-11264
    • Crichton, R.R.1    Ward, R.J.2
  • 35
    • 0017872475 scopus 로고
    • Microsomal lipid peroxidation
    • Buege, J.A., and S.D. Aust. 1978. Microsomal lipid peroxidation. Methods Enzymol. 52:302-310.
    • (1978) Methods Enzymol. , vol.52 , pp. 302-310
    • Buege, J.A.1    Aust, S.D.2
  • 36
    • 0025050763 scopus 로고
    • Effects of (+)-1.2-bis(3,5-dioxopiperazin-1-yl)propane (ADR-529) on iron-catalyzed lipid peroxidation
    • Ryan, T.P., V.M. Samokyszyn, S. Dellis, and S.D. Aust. 1990. Effects of (+)-1.2-bis(3,5-dioxopiperazin-1-yl)propane (ADR-529) on iron-catalyzed lipid peroxidation. Chem. Res. Toxicol. 3:384-390.
    • (1990) Chem. Res. Toxicol. , vol.3 , pp. 384-390
    • Ryan, T.P.1    Samokyszyn, V.M.2    Dellis, S.3    Aust, S.D.4
  • 37
    • 0025678318 scopus 로고
    • The action of hydrogen peroxide on the formation of thiobarbituric acid reactive material from microsomes, liposomes or from DNA damaged by bleomycin or phenanthroline. Artefacts in the thiobarbituric acid test
    • Cecchini, R., O.I. Aruoma, and B. Halliwell. 1990. The action of hydrogen peroxide on the formation of thiobarbituric acid reactive material from microsomes, liposomes or from DNA damaged by bleomycin or phenanthroline. Artefacts in the thiobarbituric acid test. Fee Rad. Res. Commun. 10:245-258.
    • (1990) Fee Rad. Res. Commun. , vol.10 , pp. 245-258
    • Cecchini, R.1    Aruoma, O.I.2    Halliwell, B.3
  • 38
    • 0026781532 scopus 로고
    • The assembly and secretion of apoB 100-containing lipoproteins in Hep G2 cells
    • Boren, J., L. Graham, M. Weitesten, J. Scott, A. White, and S.-O. Olofsson. 1992. The assembly and secretion of apoB 100-containing lipoproteins in Hep G2 cells. J. Biol. Chem. 267:9858-9867.
    • (1992) J. Biol. Chem. , vol.267 , pp. 9858-9867
    • Boren, J.1    Graham, L.2    Weitesten, M.3    Scott, J.4    White, A.5    Olofsson, S.-O.6
  • 40
    • 0027131517 scopus 로고
    • Content of amioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibilty of human LDL to metal ion-dependent and -independent oxidation
    • Frei, B., and J.M. Graziano. 1993. Content of amioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibilty of human LDL to metal ion-dependent and -independent oxidation. J. Lipid Res. 34: 2135-2145.
    • (1993) J. Lipid Res. , vol.34 , pp. 2135-2145
    • Frei, B.1    Graziano, J.M.2
  • 41
    • 0028902346 scopus 로고
    • Secondary alcohol metabolites mediate iron delocalization in cytosolic fractions of myocardial biopsies exposed to anticancer anthracyclines
    • Minotti, G., A.F. Cavaliere, A. Mordente, M. Rossi, R. Schiavello, R. Zamparelli, and G.F. Possati. 1995. Secondary alcohol metabolites mediate iron delocalization in cytosolic fractions of myocardial biopsies exposed to anticancer anthracyclines. J. Clin. Invest. 95:1595-1605.
    • (1995) J. Clin. Invest. , vol.95 , pp. 1595-1605
    • Minotti, G.1    Cavaliere, A.F.2    Mordente, A.3    Rossi, M.4    Schiavello, R.5    Zamparelli, R.6    Possati, G.F.7
  • 42
    • 0018729867 scopus 로고
    • Studies on the mobilization of iron from ferritin by isolated rat liver mitochondria
    • Ulvik, R., and I. Romslo. 1979. Studies on the mobilization of iron from ferritin by isolated rat liver mitochondria. Biochim. Biophys. Acta. 588:256-271.
    • (1979) Biochim. Biophys. Acta , vol.588 , pp. 256-271
    • Ulvik, R.1    Romslo, I.2
  • 43
    • 0025211779 scopus 로고
    • Quantitation of Protein
    • Stoscheck, C.M. 1990. Quantitation of Protein. Methods Enzymol. 182: 50-68.
    • (1990) Methods Enzymol. , vol.182 , pp. 50-68
    • Stoscheck, C.M.1
  • 45
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.). 227:680-685.
    • (1970) Nature (Lond.) , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 46
    • 0026030318 scopus 로고
    • On the identification of a conjugated diene component of duodenal bile as 9Z.11E-octodecadienoic acid
    • Smith, G.N., M. Taj, and J.M. Braganza. 1991. On the identification of a conjugated diene component of duodenal bile as 9Z.11E-octodecadienoic acid. Free Radical Biol. & Med. 10:13-21.
    • (1991) Free Radical Biol. & Med. , vol.10 , pp. 13-21
    • Smith, G.N.1    Taj, M.2    Braganza, J.M.3
  • 47
    • 0022873302 scopus 로고
    • Lipid peroxidation and molecular damage to polyunsaturated fatty acids in rat liver. Recognition of two classes of hydroperoxides formed under conditions in vivo
    • Corongiu, F.P., G. Poli, M.U. Dianzani, K.H. Cheeseman, and T.F. Slater. 1986. Lipid peroxidation and molecular damage to polyunsaturated fatty acids in rat liver. Recognition of two classes of hydroperoxides formed under conditions in vivo. Chem. Biol. Interact. 59:147-155.
    • (1986) Chem. Biol. Interact. , vol.59 , pp. 147-155
    • Corongiu, F.P.1    Poli, G.2    Dianzani, M.U.3    Cheeseman, K.H.4    Slater, T.F.5
  • 48
    • 0023113392 scopus 로고
    • Effect of oxygen tension on the generation of alkanes and malondialdehyde by peroxidizing rat liver microsomes
    • Reiter, R., and R.F. Burk. 1987. Effect of oxygen tension on the generation of alkanes and malondialdehyde by peroxidizing rat liver microsomes. Biochem. Pharmacol. 36:925-929.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 925-929
    • Reiter, R.1    Burk, R.F.2
  • 49
    • 0021288833 scopus 로고
    • An overview of methods used for detecting lipid peroxidation
    • Slater, T.F. 1984. An overview of methods used for detecting lipid peroxidation. Methods Enzymol. 105:283-293.
    • (1984) Methods Enzymol. , vol.105 , pp. 283-293
    • Slater, T.F.1
  • 51
    • 0022266582 scopus 로고
    • 2 dependent release of fatty acids from peroxidized membranes
    • 2 dependent release of fatty acids from peroxidized membranes. J. Free Radicals Biol. & Med. 1:263-271.
    • (1985) J. Free Radicals Biol. & Med. , vol.1 , pp. 263-271
    • Sevanian, A.1    Kim, E.2
  • 53
    • 0025973262 scopus 로고
    • Early measurement of systemic lipid peroxidation products in the plasma of major blunt trauma patients
    • Girotti, M.J., N. Khan, and B.A. McLellan. 1991. Early measurement of systemic lipid peroxidation products in the plasma of major blunt trauma patients. J. Trauma. 31:32-35.
    • (1991) J. Trauma , vol.31 , pp. 32-35
    • Girotti, M.J.1    Khan, N.2    McLellan, B.A.3
  • 54
    • 0025990443 scopus 로고
    • Differential detection of plasma lipid hydroperoxides in sepsis
    • Keen, R.R., L. Stella, D.P. Flanigan, and W.E. Lands. 1991. Differential detection of plasma lipid hydroperoxides in sepsis. Crit. Care Med. 19:1114-1119
    • (1991) Crit. Care Med. , vol.19 , pp. 1114-1119
    • Keen, R.R.1    Stella, L.2    Flanigan, D.P.3    Lands, W.E.4
  • 55
    • 0028151550 scopus 로고
    • Monitoring oxidative damage in patients with liver cirrhosis and different daily alcohol intake
    • Clot, P., M. Tabone, S. Arico, and E. Albano. 1994. Monitoring oxidative damage in patients with liver cirrhosis and different daily alcohol intake. Gut. 35:1637-1643.
    • (1994) Gut , vol.35 , pp. 1637-1643
    • Clot, P.1    Tabone, M.2    Arico, S.3    Albano, E.4
  • 56
    • 0025940814 scopus 로고
    • Free and bound malondialdehyde measured as thiobarbituric acid adduct by HPLC in serum and plasma
    • Carbonneau, M.A., E. Peuchant, D. Sess, P. Canioni, and M. Clerc. 1991. Free and bound malondialdehyde measured as thiobarbituric acid adduct by HPLC in serum and plasma. Clin. Chem. 37:1423-1429.
    • (1991) Clin. Chem. , vol.37 , pp. 1423-1429
    • Carbonneau, M.A.1    Peuchant, E.2    Sess, D.3    Canioni, P.4    Clerc, M.5
  • 57
    • 0028231572 scopus 로고
    • Elevated plasma lipid peroxide content correlates with rapid plasma clearance of all-trans retinoic acid in patients with advanced cancer
    • Muindi, J.F., H.I. Scher, J.R. Rigas, R.P. Warrell, and C.W. Young. 1994. Elevated plasma lipid peroxide content correlates with rapid plasma clearance of all-trans retinoic acid in patients with advanced cancer. Cancer Res. 54:2125-2128.
    • (1994) Cancer Res. , vol.54 , pp. 2125-2128
    • Muindi, J.F.1    Scher, H.I.2    Rigas, J.R.3    Warrell, R.P.4    Young, C.W.5
  • 58
    • 0027048748 scopus 로고
    • Effects of tumor necrosis factor-α on peroxidation of plasma lipoprotein lipids in experimental animals and patients
    • Donagh, J., E.T. Fossel, R.L. Kradin, S.M. Dubinett, M. Laposata, and Y.A. Hallaq. 1992. Effects of tumor necrosis factor-α on peroxidation of plasma lipoprotein lipids in experimental animals and patients. Blood. 80:3217-3226.
    • (1992) Blood , vol.80 , pp. 3217-3226
    • Donagh, J.1    Fossel, E.T.2    Kradin, R.L.3    Dubinett, S.M.4    Laposata, M.5    Hallaq, Y.A.6
  • 59
  • 60
    • 0027375273 scopus 로고
    • Serum beta-carotene and antioxidant micronutrients in children with cancer. The "Cancer children and antioxidant micronutrients" French Study Group
    • Malvy, D.J., B. Burtschy, J. Arnaud, D. Sommelet, G. Leverger, L. Dostalova, J. Drucker, and O. Amedee-Manesme. 1993. Serum beta-carotene and antioxidant micronutrients in children with cancer. The "Cancer children and antioxidant micronutrients" French Study Group. Int. J. Epidemiol. 22: 761-771.
    • (1993) Int. J. Epidemiol. , vol.22 , pp. 761-771
    • Malvy, D.J.1    Burtschy, B.2    Arnaud, J.3    Sommelet, D.4    Leverger, G.5    Dostalova, L.6    Drucker, J.7    Amedee-Manesme, O.8
  • 61
    • 0027700754 scopus 로고
    • Critical re-appraisal of vitamins and trace minerals in nutritional support of cancer patients
    • Stahelin, B. 1993. Critical re-appraisal of vitamins and trace minerals in nutritional support of cancer patients. Support. Care Cancer. 1:295-297.
    • (1993) Support. Care Cancer , vol.1 , pp. 295-297
    • Stahelin, B.1
  • 63
    • 0025832631 scopus 로고
    • 2 by adriamycin in vitro. Role of drug-lipid interactions
    • 2 by adriamycin in vitro. Role of drug-lipid interactions. J. Biol. Chem. 266:6302-6307.
    • (1991) J. Biol. Chem. , vol.266 , pp. 6302-6307
    • Mustonen, P.1    Kinnunen, P.K.2
  • 64
    • 0023597360 scopus 로고
    • An investigation into the mechanism of citrate-Fe(II) dependent lipid peroxidation
    • Minotti, G., and S.D. Aust. 1987. An investigation into the mechanism of citrate-Fe(II) dependent lipid peroxidation. Free Radical Biol. & Med. 3:379-387.
    • (1987) Free Radical Biol. & Med. , vol.3 , pp. 379-387
    • Minotti, G.1    Aust, S.D.2
  • 65
    • 0022853319 scopus 로고
    • The involvement of iron in lipid peroxidation: Importance of ferric to ferrous ratios in initiation
    • Braughler, J.M., L.A. Duncan, and R.L. Chase. 1986. The involvement of iron in lipid peroxidation: importance of ferric to ferrous ratios in initiation. J. Biol. Chem. 261:10282-10289.
    • (1986) J. Biol. Chem. , vol.261 , pp. 10282-10289
    • Braughler, J.M.1    Duncan, L.A.2    Chase, R.L.3
  • 66
    • 0023507965 scopus 로고
    • Delayed ferrous iron-dependent peroxidation of rat liver microsomes
    • Goddard, J.G., and G.D. Sweeney. 1987. Delayed ferrous iron-dependent peroxidation of rat liver microsomes. Arch. Biochem. Biophys. 259:372-381.
    • (1987) Arch. Biochem. Biophys. , vol.259 , pp. 372-381
    • Goddard, J.G.1    Sweeney, G.D.2
  • 68
    • 0025372139 scopus 로고
    • Ferric iron dependent lipid peroxidation in erythrocyte membranes: Effects of phytic acid and butylated hydroxytoluene
    • Ko, K.M., and D.V. Godin. 1990. Ferric iron dependent lipid peroxidation in erythrocyte membranes: effects of phytic acid and butylated hydroxytoluene. Mol. Cell. Biochem. 95:125-131.
    • (1990) Mol. Cell. Biochem. , vol.95 , pp. 125-131
    • Ko, K.M.1    Godin, D.V.2
  • 69
    • 0025688198 scopus 로고
    • NADPH- and NADH- dependent oxygen radical generation by rat liver nuclei in the presence of redox cycling agents and iron
    • Kukielka, E., and A.I. Cederbaum. 1990. NADPH- and NADH- dependent oxygen radical generation by rat liver nuclei in the presence of redox cycling agents and iron. Arch. Biochem. Biophys. 283:326-333.
    • (1990) Arch. Biochem. Biophys. , vol.283 , pp. 326-333
    • Kukielka, E.1    Cederbaum, A.I.2
  • 71
    • 0025240095 scopus 로고
    • NADPH- and adriamycin-dependent microsomal release of iron and lipid peroxidation
    • Minotti, G. 1990. NADPH- and adriamycin-dependent microsomal release of iron and lipid peroxidation. Arch. Biochem. Biophys. 277:268-276.
    • (1990) Arch. Biochem. Biophys. , vol.277 , pp. 268-276
    • Minotti, G.1
  • 72
    • 0023855409 scopus 로고
    • Tin-protoporphyrin inhibits heme oxygenase and prevents the decline in hepatic heme and cytochrome P-450 contents produced in nude mice by tumor transplantation
    • Wissel, P.S., R.A. Galbraith, S. Sassa, and A. Kappas. 1988. Tin-protoporphyrin inhibits heme oxygenase and prevents the decline in hepatic heme and cytochrome P-450 contents produced in nude mice by tumor transplantation. Biochem. Biophy. J. Res. Commun. 150:822-827.
    • (1988) Biochem. Biophy. J. Res. Commun. , vol.150 , pp. 822-827
    • Wissel, P.S.1    Galbraith, R.A.2    Sassa, S.3    Kappas, A.4
  • 73
    • 0027364195 scopus 로고
    • Interleukin-2-dependent transcriplional and post-transeriptional regulation of transferrin receptor mRNA
    • Seiser, C., S. Teixeira, and L.C. Kuhn. 1993. Interleukin-2-dependent transcriplional and post-transeriptional regulation of transferrin receptor mRNA. J. Biol. Chem. 268:13074-13080.
    • (1993) J. Biol. Chem. , vol.268 , pp. 13074-13080
    • Seiser, C.1    Teixeira, S.2    Kuhn, L.C.3
  • 74
    • 0026666346 scopus 로고
    • r 66,000 Microsomal Iron Protein that stimulates NADPH oxidation
    • r 66,000 Microsomal Iron Protein that stimulates NADPH oxidation. J. Biol. Chem. 267:7611-7614.
    • (1992) J. Biol. Chem. , vol.267 , pp. 7611-7614
    • Minotti, G.1    Ikeda-Saito, M.2
  • 75
    • 0027080934 scopus 로고
    • Cellular pool of transient ferric iron, chelatable by desferrioxamine and distinct from ferritin, that is involved in oxidative injury
    • Rothman, R.A., J.A. Serroni, and J.L. Farber. 1992. Cellular pool of transient ferric iron, chelatable by desferrioxamine and distinct from ferritin, that is involved in oxidative injury. Mol. Pharmacol. 42:703-710.
    • (1992) Mol. Pharmacol. , vol.42 , pp. 703-710
    • Rothman, R.A.1    Serroni, J.A.2    Farber, J.L.3
  • 76
    • 0026730687 scopus 로고
    • Stoichiometry of Fe(II) oxidation during ceruloplasmin-catalyzed loading of ferrilin
    • deSilva, D., and S.D. Aust. 1992. Stoichiometry of Fe(II) oxidation during ceruloplasmin-catalyzed loading of ferrilin. Arch. Biochem. Biophys. 298: 259-264.
    • (1992) Arch. Biochem. Biophys. , vol.298 , pp. 259-264
    • DeSilva, D.1    Aust, S.D.2
  • 77
    • 0024545103 scopus 로고
    • Adriamycin-dependent release of iron from microsomal membranes
    • Minotti, G. 1989. Adriamycin-dependent release of iron from microsomal membranes. Arch. Biochem. Biophys. 268:398-403.
    • (1989) Arch. Biochem. Biophys. , vol.268 , pp. 398-403
    • Minotti, G.1
  • 78
    • 10244258963 scopus 로고
    • Prospective studies of tocopherol prophylaxis for anthracycline cardiac toxicity
    • Weitzman, S.A., B. Lorell, R.W. Carey, S. Kaufman, and T.P. Stossel. 1980. Prospective studies of tocopherol prophylaxis for anthracycline cardiac toxicity. Am. J. Cardiol. 56:157-161.
    • (1980) Am. J. Cardiol. , vol.56 , pp. 157-161
    • Weitzman, S.A.1    Lorell, B.2    Carey, R.W.3    Kaufman, S.4    Stossel, T.P.5
  • 79
    • 0020583667 scopus 로고
    • A randomized controlled trial assessing the prevention of doxorubicin cardiomyopathy by N-acetyleysteine
    • Myers. C., R. Bonow, S. Palmieri, J. Jenkins, B. Corden, G. Locker, J. Doroshow, and S.A. Epstein. 1983. A randomized controlled trial assessing the prevention of doxorubicin cardiomyopathy by N-acetyleysteine. Sem. Oncol. 10(Suppl.):53-55.
    • (1983) Sem. Oncol. , vol.10 , Issue.SUPPL. , pp. 53-55
    • Myers, C.1    Bonow, R.2    Palmieri, S.3    Jenkins, J.4    Corden, B.5    Locker, G.6    Doroshow, J.7    Epstein, S.A.8
  • 80
    • 0028538590 scopus 로고
    • Cytoprotection: Concepts and challenges
    • Muggia, F.M. 1994. Cytoprotection: concepts and challenges. Support. Care Cancer. 2:377-379.
    • (1994) Support. Care Cancer , vol.2 , pp. 377-379
    • Muggia, F.M.1
  • 81
    • 0028945064 scopus 로고
    • Doxorubicin reduces the iron (III) complexes of the hydrolysis products of the antioxidant cardioprotective agent dexrazoxane (ICRF-187) and produces hydroxyl radicals
    • Malisza, K.L., and B.B. Hasinoff. 1995. Doxorubicin reduces the iron (III) complexes of the hydrolysis products of the antioxidant cardioprotective agent dexrazoxane (ICRF-187) and produces hydroxyl radicals. Arch. Biochem. Biophys. 316:6811-688.
    • (1995) Arch. Biochem. Biophys. , vol.316 , pp. 6811-7688
    • Malisza, K.L.1    Hasinoff, B.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.