Activation of the human RANTES gene promoter in a macrophage cell line by lipopolysaccharide is dependent on stress-activated protein kinases and the IκB kinase cascade: Implications for exacerbation of allergic inflammation by environmental pollutants

Clinical Immunology

Volumn 90, Issue 3, 1999, Pages 287-301

  Hiura, Timothy S ^a   Kempiak, Stephan J ^a   Nel, Andre E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

LPS; Promoter; RANTES

Indexed keywords

ENVIRONMENTAL CHEMICAL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; RANTES; STRESS ACTIVATED PROTEIN KINASE; TERT BUTYLHYDROQUINONE;

ALLERGY; ARTICLE; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOREGULATION; IMMUNOTOXICITY; MACROPHAGE; MACROPHAGE ACTIVATION; PRIORITY JOURNAL; PROMOTER REGION;

EID: 0032900164     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.1998.4659     Document Type: Article

References (40)

1. Bradley, B. L., Azzawi, M., Jacobson, M., Assoufi, B., Collins, J. V., Irani, A. M., Schwartz, L. B., Durham, S. R., Jeffery, P. K., and Kay, A. B., Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: Comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J. Allergy Clin. Immunol. 8, 661-674, 1991.
2. Kita, H., and Gleich, G. J., Chemokines active on eosinophils: Potential roles in allergic inflammation. J. Exp. Med. 183, 2421-2426, 1996.
3. Alam, R., York, J., Boyars, M., Stafford, S., Grant, J. A., Lee, J., Forsythe, P., Sim, T., and Ida, N., Increased MCP-1, RANTES, and MIP-1alpha in bronchoalveolar lavage fluid of allergic asthmatic patients. Am. J. Respir. Crit. Care Med. 153, 1398-1404, 1996.
4. Baggiolini, M., Loetscher, P., and Moser, B., Interleukin-8 and the chemokine family. Int. J. Immunopharm. 17, 103-108, 1995.
5. Baggiolini, M., Dewald, B., and Moser, B., Human chemokines: An update. Ann. Rev. Immunol. 15, 675-705, 1997.
6. Schall, T. J., Biology of the RANTES/SIS cytokine family. Cytokine 3, 165-183, 1991.
7. Folkard, S. G., Westwick, J., and Millar, A. B., Production of interleukin-8, RANTES and MCP-1 in intrinsic and extrinsic asthmatics. Eur. Respir. J. 10, 2097-2104, 1997.
8. Thomas, L. H., Friedland, J. S., Sharland, M., and Becker, S., Respiratory syncytial virus-induced RANTES production from human bronchial epithelial cells is dependent on nuclear factor-kappa B nuclear binding and is inhibited by adenovirus-mediated expression of inhibitor of kappa B alpha. J. Immunol. 161, 1007-1016, 1998.
9. Nelson, P. J., Kim, H. T., Manning, W. C., Goralski, T. J., and Krensky, A. M., Genomic organization and transcriptional regulation of the RANTES chemokine gene. J. Immunol. 151, 2601-2612, 1993.
10. Danoff, T. M., Lalley, P. A., Chang, Y. S., Heeger, P. S., and Neilson, E. G., Cloning, genomic organization, and chromosomal localization of the Scya gene encoding the murine chemokine RANTES. J. Immunol. 152, 1182-1189, 1994.
11. Nelson, P. J., Ortiz, B. D., Pattison, J. M., and Krensky, A. M., Identification of a novel regulatory region critical for expression of the RANTES chemokine in activated T lymphocytes. J. Immunol. 157, 1139-1148, 1996.
12. Ortiz, B. D., Krensky, A. M., and Nelson, P. J., Kinetics of transcription factors regulating the RANTES chemokine gene reveal a developmental switch in nuclear events during T-lymphocyte maturation. Mol. Cell. Biol. 16, 202-210, 1996.
13. Moriuchi, H., Moriuchi, M., and Fauci, A. S., Nuclear factor-kappa B potently up-regulates the promoter activity of RANTES, a chemokine that blocks HIV infection. J. Immunol. 158, 3483-3491, 1997.
14. Shin, H. S., Drysdale, B. E., Shin, M. L., Noble, P. W., Fisher, S. N., and Paznekas, W. A., Definition of a lipopolysaccharide-responsive element in the 5′-flanking regions of MuRantes and crg-2. Mol. Cell. Biol. 14, 2914-2925, 1994.
15. Kwon, O. J., Jose, P. J., Robbins, R. A., Schall, T. J., Williams, T. J., and Barnes, P. J., Glucocorticoid inhibition of RANTES expression in human lung epithelial cells. Am. J. Respir. Cell. Mol. Biol. 12, 488-496, 1995.
16. Kayama, F., Yoshida, T., Kodama, Y., Matsui, T., Matheson, J. M., and Luster, M. I., Proinflammatory cytokines and interleukin 6 in the renal response to bacterial endotoxin. Cytokine 9, 688-695, 1997.
17. Platts-Mills, T. A., Sporik, R. B., Chapman, M. D., and Heymann, P. W., The role of domestic allergens. Ciba Found. Symp. 206, 173-189, 1997.
18. Michel, O., Kips, J., Duchateau, J., Vertongen, F., Robert, L., Collet, H., Pauwels, R., and Sergysels, R., Severity of asthma is related to endotoxin in house dust. Am. J. Respir. Crit. Care Med. 154, 1641-1646, 1996.
19. Burrell, R., Human responses to bacterial endotoxin. Circ. Shock 43, 137-153, 1994.
20. Diaz-Sanchez, D., Jyrala, M., Ng, D., Nel, A. E., and Saxon, A., In vivo nasal challenge with diesel exhaust particles enhances expression of the CC chemokines rantes, MIP-1a and MCP-3 in humans. Am. J. Respir. Cell. Mol. Biol., in press, 1998.
21. Nel, A., Diaz-Sanchez, D., Ng, D., Hiura, T., and Saxon, A., Enhancement of allergic inflammation by the interaction between diesel exhaust particles (DEP) and the immune system. J. Allergy Clin. Immunol. 102, 539-554, 1998.
22. Minden, A., and Karin, M., Regulation and function of the JNK subgroup of MAP kinases. Biochim. Biophys. Acta 1333, F85-104, 1997.
23. Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M., and Karin, M., The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 91, 243-252, 1997.
24. DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., and Karin, M., A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 388, 548-554, 1997.
25. Regnier, C. H., Song, H. Y., Gao, X., Goeddel, D. V., Cao, Z., and Rothe, M., Identification and characterization of an IkappaB kinase. Cell 90, 373-383, 1997.
26. Minden, A., Lin, A., McMahon, M., Lange-Carter, C., Derijard, B., Davis, R. J., Johnson, G. L., and Karin, M., Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266, 1719-1723, 1994.
27. Faris, M., Kokot, N., Lee, L., and Nel, A. E., Regulation of interleukin-2 transcription by inducible stable expression of dominant negative and dominant active mitogen-activated protein kinase kinase kinase in jurkat T cells. Evidence for the importance of Ras in a pathway that is controlled by dual receptor stimulation. J. Biol. Chem. 271, 27366-27373, 1996.
28. Faris, M., Latinis, K. M., Kempiak, S. J., Koretzky, G. A., and Nel, A., Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter. Mol. Cell. Biol. 18, 5414-5424, 1998.
29. Ng, D., Kokot, N., Hiura, T., Faris, M., Saxon, A., and Nel, A., Macrophage activation by polycyclic aromatic hydrocarbons: Evidence for the involvement of stress-activated protein kinases, activator protein-1, and antioxidant response elements. J. Immunol. 161, 942-951, 1998.
30. Hambleton, J., Weinstein, S. L., Lem, L., and DeFranco, A. L., Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc. Natl. Acad. Sci. USA 93, 2774-2778, 1996.
31. Sweet, M. J., and Hume, D. A., Endotoxin signal transduction in macrophages. J. Leukocyte Biol. 60, 8-26, 1996.
32. Petrak, D., Memon, S. A., Birrer, M. J., Ashwell, J. D., Zacharchuk, C. M., Dominant negative mutant of c-Jun inhibits NF-AT transcriptional activity and prevents IL-2 gene transcription. J. Immunol. 153, 2046-2051, 1994.
33. Ling, L., Cao, Z., and Goeddel, D. V., NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Proc. Natl. Acad. Sci. USA 95, 3792-3797, 1998.
34. Peterson, B., and Saxon, A., Global increases in allergic respiratory disease: The possible role of diesel exhaust particles. Ann. Allergy Asthma Immunol. 77, 263-270, 1996.
35. Gonzalo, J. A., Lloyd, C. M., Wen, D., Albar, J. P., Wells, T. N., Proudfoot, A., Martinez, A. C., Dorf, M., Bjerke, T., Coyle, A. J., et al., The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness. J. Exp. Med. 188, 157-167, 1998.
36. Kimata, H., Yoshida, A., Ishioka, C., Fujimoto, M., Lindley, I., and Furusho, K., RANTES and macrophage inflammatory protein 1 alpha selectively enhance immunoglobulin (IgE) and IgG4 production by human B cells. J. Exp. Med. 183, 2397-2402, 1996.
37. Manni, A., Kleimberg, J., Ackerman, V., Bellini, A., Patalano, F., and Mattoli, S., Inducibility of RANTES mRNA by IL-1beta in human bronchial epithelial cells is associated with increased NF-kappaB DNA binding activity. Biochem. Biophys. Res. Commun. 220, 120-124, 1996.
38. Jenkins, F., Cockerill, P. N., Bohmann, D., and Shannon, M. F., Multiple signals are required for function of the human granulocyte-macrophage colony-stimulating factor gene promoter in T cells. J. Immunol. 155, 1240-1251, 1995.
39. Wissink, S., van de Stolpe, A., Caldenhoven, E., Koenderman, L., and van der Saag, P. T., NF-kappa B/Rel family members regulating the ICAM-1 promoter in monocytic THP-1 cells. Immunobiology 190, 50-64, 1997.
40. Shakhov, A. N., Collart, M. A., Vassalli, P., Nedospasov, S. A., and Jongeneel, C. V., Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages. J. Exp. Med. 171, 35-47, 1990.