Lymphocyte activation in allergic reactions elicited by small-molecular-weight compounds

International Archives of Allergy and Immunology

Volumn 113, Issue 1-3, 1997, Pages 173-176

  Merk, Hans F ^a   Baron, Jens ^a   Hertl, Michael ^a   Niederau, Doris ^a   Rübben, Albert ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Chloramphenicol; Cytochrome P450; Fragrances; Lymphocyte transformation test; Monocytes; P Phenylenediamine; Sulfonamides

Indexed keywords

CHLORAMPHENICOL; CYTOCHROME P450; PHENYLENEDIAMINE; SULFAMETHOXAZOLE;

ALLERGIC REACTION; CONFERENCE PAPER; GENE EXPRESSION; LYMPHOCYTE ACTIVATION; MONOCYTE; PRIORITY JOURNAL;

CHLORAMPHENICOL; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; HYPERSENSITIVITY; LYMPHOCYTE ACTIVATION; MOLECULAR WEIGHT; MONOCYTES; PHENYLENEDIAMINES; SULFONAMIDES;

EID: 0030993525     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000237538     Document Type: Article

References (22)

1. Basketter DA, Pendlington RU, Sarll A, Scholcs E: The role of P450 IA in the activation of prohaptens in skin sensitization (abstract), J Invest Dermatol 1996; 106:915.
2. Beaune PH, Guengerich FP: Human drug metabolism in vitro, Pharmacol Ther 1988;37: 193-211.
3. Dietrich A, Kawakubo Y, Rzany B, Schöpf F,: Patients with severe cutaneous drug reactions (EM, SJS, TEN) have a reduced N-acetylating capacity (abstract), J Invest Dermatol 1993; 100:519.
4. Fujino T, Park SS, Gelboin H V: Phenotyping of cytochrome P-450 in human tissue with monoclonal antibodies, Proc Nat Acad Sei USA 1982;79:3682-3686.
5. Gonzalez FJ: Molecular genetics of the P-450 superfamily, Pharmacol Ther 1990;45:1-38.
6. Guengerich FP, Liebler DC: Enzymatic activation of chemicals to toxic metabolites, C'rit Rev Toxicol 1985:14:259-307.
7. Herd M, Jugert F, Merk HF: CD8+ dermal T-cells from a sulfamethoxazole-induced bullous exanthem proliferate in response to drug-modified liver microsomes, Br J Dermatol 1995; 132:215-220.
8. Herd M, Niederau D, Merk HF: The use of epidermal and dermal T-lymphocytc clones in studies on the pathophysiology of bullous drug eruptions; in Maibach 11 (ed): Dermatological Research Techniques, Boca Raton, CRC Press 1996. pp 11-22.
9. Herd M, Merk HF: Lymphocyte activation in cutaneous drug reactions, J Invest Dermatol 105;1995:95-98
10. Lcedcr JS, Cannon M, Nakhooda A, Spielberg SP: Drug metabolite toxicity assessed in human lymphocytes with a purified, reconstituted cytochrome P-450 system, J Pharmacol Exp Ther 1988;245:956-962.
11. Merk HF, Niederau D, Herd M, Jugert F: Drug metabolism and drug allergy; in Ring J, Przybil-la B (eds): New Trends in Allergy III, Heidelberg, Springer, 1991. pp 269-280.
12. Merk HF: Skin metabolism; in Lepoittevin JP, Basketter D, Dooms-Goossens A, Karlberg AT (eds): Molecular Basis of Allergic Contact Dermatitis, Heidelberg, Springer, in press
13. Meyer UA: Molecular genetics and the future of pharmacogenetics, Pharmacol Ther 1990;46: 349-355.
14. Ncbert DW, Nelson DR, Adesnik M, Coon MJ, Estabrook RW, Gonzales FJ, Guengerich FP, Gunsalus IC, Johnson EF, Kemper B, Levin W, Phillips IR, Sato R, Waterman MR: The P450 superfamily: Update on listing of all genes and recommended nomenclature of the chromosomal loci, DNA 1989;8:1-13.
15. Niederau D, Herd M, Boccker C, Geisel J, Merk H: CD4+ antigen-specific cytotoxic T lymphocytes are present in contact hypersensitivity reactions to fragrances (abstract), J Invest Dermatol 1994;102:480.
16. Park BK, Pirmohamcd M, Kitteringham NR: The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity, Pharmacol Ther 1995:68:385-424.
17. Rieder MJ, Uetrecht J, Shear NH, Spielberg SP: Synthesis and in vitro toxicity of hydroxylaminc metabolites of sulfonamides, J Pharmacol Exp Ther 1988;244:724-728.
18. Rieder MJ, Uetrecht J, Shear NH, Cannon M, Miller M, Spielberg SP: Diagnosis of sulfonamide hypersensitivity reactions by in-vitro ‘rc-challenge’ with hydroxylamine metabolites, Ann Int Med I989;l 10:286-289.
19. Shear NH, Spielberg SP, Grant DM, Tang BK, Kalow W: Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity, Ann Int Med 1986:105:179-184.
20. Vesell ES: Pharmacogenetic perspectives: Genes, drugs and disease, Hepatology 1984:4: 959-965.
21. Ziegler-Heitbrock HWL, Thiel E, Fiitterer A, Herzog Riethmüller G: Establishment of a human cell line (Mono MAC6) with characteristics of mature monocytes, Int J Cancer 1988:41: 456-461.
22. Zwadlo-Klarwasser G, Bent St, Haubeck HD, Sorg C, Schmutzler W: Glucocorticoid-induced appearance of the macrophage subtype RM3/1 in peripheral blood of man, Int Arch Appl Immunol 1990;91:175-180