In vivo genetic analysis indicates that PhoP-PhoQ and the Salmonella pathogenicity island 2 type III secretion system contribute independently to salmonella enterica serovar typhimurium virulence

Infection and Immunity

Volumn 69, Issue 12, 2001, Pages 7254-7261

  Beuzon C R ^a   Unsworth, K E ^a   Holden, D W ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SALMONELLA PATHOGENICITY ISLAND 1; SALMONELLA PATHOGENICITY ISLAND 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BACTERIAL INFECTION; BACTERIAL VIRULENCE; COLONY FORMING UNIT; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC ANALYSIS; MOUSE; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALMONELLA; SALMONELLA ENTERICA; STRAIN DIFFERENCE;

ANIMALS; BACTERIAL PROTEINS; FEMALE; GENETIC COMPLEMENTATION TEST; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; PROTEIN TRANSPORT; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION;

EID: 0035184351     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.12.7254-7261.2001     Document Type: Article

References (60)

1. Salmonella typhimurium activates virulence gene transcription within acidified macrophage phagosomes
2. Regulation of Salmonella enterica serovar Typhimurium invasion genes by csrA
3. HilA is a novel ompR/toxR family member that activates the expression of Salmonella typhimurium invasion genes
4. Co-ordinate regulation of Salmonella typhimurium invasion genes by environmental and regulatory. Factors is mediated by control of hilA expression
5. Synergistic effect of mutations in invA and lpfC on the ability of Salmonella typhimurium to cause murine typhoid
6. A PhoP-repressed gene promotes Salmonella typhimurium invasion of epithelial cells
7. PH-dependent secretion of SseB, a product of the SPI-2 type III secretion system of Salmonella typhimurium
8. Salmonella maintains the integrity of its intracellular vacuole through the action of SifA
9. Induction of Salmonella stress proteins upon infection of macrophages
10. Specialized transduction of tetracycline resistance by phage P22 in Salmonella typhimurium. II. Properties of a high-frequency-transducing lysate
11. Macrophage-dependent induction of the Salmonella pathogenicity island 2 type Ill secretion system and its role in intracellular survival
12. Type III secretion by Salmonella typhimurium does not require contact with a eukaryotic host
13. InvF is required for expression of genes encoding proteins secreted by the SPII type III secretion apparatus in Salmonella typhimurium
14. Environmental regulation of Salmonella pathogenicity island 2 gene expression
15. Mutations in Salmonella pathogenicity island 2 (SPI2) genes affecting transcription of SPI1 genes and resistance to antimicrobial agents
16. Characterization of porin and ompR mutants of a virulent strain of Salmonella typhimurium: OmpR mutants are attenuated in vivo
17. Differential regulation of Salmonella typhimurium type III secreted proteins by pathogenicity island 1 (SPI-1)encoded transcriptional activators InvF and HilA
18. Characterization of SprA, an AraC-like transcriptional regulator encoded within the Salmonella typhimurium pathogenicity island 1
19. A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells
20. Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent
21. Molecular and cellular mechanisms of Salmonella pathogenesis
22. Role of chemotaxis in the association of motile bacteria with intestinal mucosa: In vivo studies
23. Molecular genetic bases of Salmonella entry into host cells
24. Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells
25. Salmonella typhimurium phoP virulence gene is a transcriptional regulator
26. How Salmonella became a pathogen
27. Resistance to host antimicrobial peptides is necessary for Salmonella virulence
28. The Salmonella typhimurium virulence plasmid increases the growth rate of salmonellae in mice
29. Simultaneous identification of bacterial virulence genes by negative selection
30. Functional analysis of ssaJ and the ssaK/U operon, 13 genes encoding components of the type III secretion apparatus of Salmonella pathogenicity island 2
31. Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages
32. Regulation of major outer membrane porin proteins of Escherichia coli K 12 by pH
33. Identification of a novel Salmonella invasion locus homologous to Shigella ipgDE
34. Type III protein secretion systems in bacterial pathogens of animals and plants
35. Transcriptional activation of Salmonella typhimurium invasion genes by a member of the phosphorylated response-regulator superfamily
36. Secreted effector proteins of Salmonella dublin act in concert to induce enteritis
37. The Salmonella typhimurium invasion genes invF and invG encode homologues of the AraC and PulD family of proteins
38. Regulation of nonspecific acid phosphatase in Salmonella: PhoN and phoP genes
39. Molecular characterization and assembly of the needle complex of the Salmonella typhimurium type III protein secretion system
40. OmpR regulates the two-component system SsrA-SsrB in Salmonella pathogenicity island 2
41. Multiple factors independently regulate hil4 and invasion gene expression in Salmonella enterica serovar Typhimurium
42. Some hypotheses on the aetiology of fatal infections in partially resistant hosts and their application to mice challenged with Salmonella paratyphi-B or Salmonella typhimurium by intraperitoneal injection
43. A conserved amino acid sequence directing intracellular type III secretion by Salmonella typhimurium
44. Salmonella typhimurium leucine-rich repeat proteins are targeted to the SPI1 and SPI2 type III secretion systems
45. A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence
46. Constitutive expression of the phop regulon attenuates Salmonella virulence and survival within macrophages
47. A 40 kb chromosomal fragment encoding Salmonella typhimurium invasion genes is absent from the corresponding region of the Escherichia coli K-12 chromosome
48. Identification of a pathogenicity island required for Salmonella survival in host cells
49. PhoP/PhoQ transcriptional repression of Salmonella typhimurium invasion genes: Evidence for a role in protein secretion
50. A HilA-independent pathway to Salmonella typhimurium invasion gene transcription
51. Two AraC/XylS family members can independently counteract the effect of repressing sequences upstream of the hil4 promoter
52. Phage P22-mutants with increased or decreased transduction abilities
53. Influence of the Salmonella typhimurium pathogenicity island 2 type III secretion system on bacterial growth in the mouse
54. Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium
55. Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin
56. The regulation of expression of the porin gene ompC by acid pH
57. Fluorescence-based isolation of bacterial genes expressed within host cells
58. Identification of a pathogenicity island required for Salmonella enteropathogenicity
59. SopE, a secreted protein of Salmonella dublin, is translocated into the target eukaryotic cell via a sip-dependent mechanism and promotes bacterial entry
60. Salmonella SsrB activates a global regulon of horizontally acquired genes