Interferon-γ-responsive neuronal sites in the normal rat brain: Receptor protein distribution and cell activation revealed by Fos induction

Brain Research Bulletin

Volumn 52, Issue 1, 2000, Pages 61-74

  Robertson, Brita ^a   Kong, Guo Ying ^b   Peng, Ze Chun ^b   Bentivoglio, Marina ^b   Kristensson, Krister ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF VERONA   (Italy)

Author keywords

Brain; Cytokines; Hypothalamus; Nervous system; Pain; Virus

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; RECOMBINANT GAMMA INTERFERON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; BRAIN; CELL ACTIVATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFECTION; INFLAMMATION; MALE; MICROPHOTOGRAPHY; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

ANIMALS; BRAIN; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAVENTRICULAR; INTERFERON TYPE II; MALE; NEURONS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, INTERFERON; REFERENCE VALUES; TISSUE DISTRIBUTION;

EID: 0034194486     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(00)00240-9     Document Type: Article

References (31)

1. Bach E.A., Aguet M., Schreiber R.D. The IFNγ receptor A paradigm for cytokine receptor signaling . Annu. Rev. Immunol. 15:1997;563-591.
2. Bannister, L. H. Sensory terminals of peripheral nerves. In: Landon, D. N., ed. The peripheral nerve. London: Chapman and Hall; 1976:396-454.
3. Behbehani M.M. Functional characteristics of the midbrain periaqueductal gray. Prog. Neurobiol. 46:1995;575-605.
4. Boehm U., Klamp T., Groot M., Howard J.C. Cellular responses to interferon-γ Annu. Rev. Immunol. 15:1997;749-795.
5. Charney D.S., Deutch A. A functional neuroanatomy of anxiety and fear Implications for the pathophysiology and treatment of anxiety disorders . Crit. Rev. Neurobiol. 10:1996;419-446.
6. Ericsson A., Liu C., Hart R.P., Sawchenko P.E. Type 1 interleukin-1 receptor in the rat brain Distribution, regulation, and relationship to sites of IL-1-induced cellular activation . J. Comp. Neurol. 361:1995;681-698.
7. Farrar M.A., Schreiber R.D. The molecular cell biology of interferon-γ and its receptor. Annu. Rev. Immunol. 11:1993;571-611.
8. Grau V., Herbst B., van der Meide P.H., Steiniger B. Activation of microglial and endothelial cells in the rat brain after treatment with interferon-gamma in vivo. Glia. 19:1997;181-189.
9. Herrera D.G., Robertson H.A. Activation of c-fos in the brain. Prog. Neurobiol. 50:1996;83-107.
10. Horwitz M.S., Evans C.F., Klier F.G., Oldstone B.A. Detailed in vivo analysis of interferon-γ induced major histocompatibility complex expression in the central nervous system Astrocytes fail to express major histocompatibility complex class I and II molecules . Lab. Invest. 79:1999;235-242.
11. Krout K.E., Jansen A.S., Loewry A.D. Periaqueductal gray matter projection to the parabrachial nucleus in rat. J. Comp. Neurol. 401:1998;437-454.
12. Lu B., Ebensberger C., Dembic Z., Wang Y., Kvatyuk M., Lu T., Coffman R.L., Pestka S., Rothman P.B. Targeted disruption of the interferon-γ receptor 2 gene results in severe immune defects in mice. Proc. Natl. Acad. Sci. USA. 95:1998;8233-8238.
13. Lundkvist G.B., Robertson B., Mhlanga J.D.M., Rottenberg M., Kristensson K. Expression of an oscillating interferon-γ receptor in the suprachiasmatic nuclei. NeuroReport. 9:1998;1059-1063.
14. Lundkvist, G. B.; Andersson, A.; Robertson, B.; Rottenberg, M. E.; Kristensson, K. Light-dependent regulation and postnatal development of the interferon-γ receptor in the rat suprachiasmatic nuclei. Brain Res. 849:231-234; 1999.
15. Molander C., Hongpaisan J., Persson J.K.E. Distribution of c-fos expressing dorsal horn neurons after electrical stimulation of low threshold sensory fibers in the chronically injured sciatic nerve. Brain Res. 644:1994;74-82.
16. Neumann H., Schmidt H., Cavalié A., Jenne D., Wekerle H. Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system Differential regulation by interferon (IFN)-γ and tumor necrosis factor (TNF)-α J. Exp. Med. 185:1997;305-316.
17. Neumann H., Schmidt H., Wilharm E., Behrens L., Wekerle H. Interferon-γ gene expression in sensory neurons evidence for autocrine gene regulation . J. Exp. Med. 186:1997;2023-2031.
18. Peng Z.-C., Chen S., Fusco M., Vantini G., Bentivoglio M. Fos induction by nerve growth factor in the adult male rat brain. Brain Res. 632:1993;57-67.
19. Peng Z.-C., Mohammed A.H., Olsson T., Edlund C., Kristensson K. Interferon-γ and a factor derived from trypanosomes cause behavioural changes in the rat. Behav. Brain Res. 62:1994;171-175.
20. Peng Z.-C., Kristensson K., Bentivoglio M. Distribution and temporal regulation of the immune response in the rat brain to intracerebroventricular injection of interferon-γ Exp. Neurol. 154:1998;403-417.
21. Popko B., Corbin J.G., Baerwald K.D., Dupree J., Garcia A.M. The effects of interferon-γ on the central nervous system. Mol. Neurobiol. 14:1997;19-35.
22. Radzioch D., Varesio L. c-fos mRNA expression in macrophages is downregulated by interferon-γ at the post-transcriptional level. Mol. Cell Biol. 11:1991;2718-2722.
23. Robertson B., Xu X.-J., Hao J.-X., Wiesenfeld-Hallin Z., Mhlanga J., Grant G., Kristensson K. Interferon-γ receptors in nociceptive pathways Role in neuropathic pain-related behavior . NeuroReport. 8:1997;1311-1316.
24. Swanson, L. W. Brain maps: Structure of the rat brain. Amsterdam: Elsevier; 1992.
25. Swanson, L. W. Brain maps: Computer graphics files. Amsterdam: Elsevier; 1993.
26. Torres C., Aránguez I., Rubio N. Expression of interferon-γ receptors on murine oligodendrocytes and its regulation by cytokines and mitogens. Immunology. 86:1995;250-255.
27. Valente G., Ozmen L., Novelli F., Geuna M., Palestro G., Forni G., Garotta G. Distribution of interferon-γ receptor in human tissues. Eur. J. Immunol. 22:1992;2403-2412.
28. Wan Y.J., Levi B.Z., Ozato K. Induction of c-fos gene expression by interferons. J. Interferon Res. 8:1988;105-112.
29. Watkins L.R., Maier S.F., Goehler L.E. Immune activation The role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states . Pain. 63:1995;289-302.
30. Vikman K., Robertson B., Grant G., Liljeborg A., Kristensson K. Interferon-γ receptors are expressed at synapses in the rat superficial dorsal horn and lateral spinal nucleus. J. Neurocytol. 27:1998;749-760.
31. Willis W.D., Westlund K.N. Neuroanatomy of the pain system and of the pathways that modulate pain. J. Clin. Neurophysiol. 14:1997;2-31.