Effect of 10% ethanol and sofalcone on prostaglandin E2 content, mucus gel thickness, and experimental ulcers in the stomach of developing rats

Digestion

Volumn 57, Issue 1, 1996, Pages 47-53

  Tabata, Masahiko ^a   Tomomasa, Takeshi ^a   Itoh, Ken ^a   Morikawa, Akihiro ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

Mild irritant; Mucosal injury; Mucus; Prostaglandin; Sofalcone

Indexed keywords

ALCOHOL; GASTROINTESTINAL MUCOSA PROTECTIVE AGENT; INDOMETACIN; PROSTAGLANDIN E2; SOFALCONE;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEFENSE MECHANISM; FEMALE; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH MUCOSA; STOMACH MUCUS; STOMACH ULCER; THICKNESS;

AGING; ANIMALS; ANIMALS, NEWBORN; ANTI-ULCER AGENTS; CHALCONE; CHALCONES; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; GASTRIC MUCOSA; INDOMETHACIN; MALE; MUCUS; RATS; RATS, WISTAR; STOMACH ULCER;

EID: 0030070440     PISSN: 00122823     EISSN: 14219867     Source Type: Journal    
DOI: 10.1159/000201312     Document Type: Article

References (18)

1. Brooks FP: The pathophysiology of peptic ulcer: An overview, in Brooks FP (ed): Peptic Ulcer Disease. New York, Churchill Livingstone, 1985, pp 45-151.
2. Wallace JL: Prostaglandins. NSAIDs, and cytoprotection. Gastroenterol Clin North Am 1992; 21:631-641.
3. Miller TA: Protective effects of prostaglandins against gastric mucosal damage: Current knowledge and proposed mechanisms. Am J Physiol 1983;245:G601-G623.
4. Robert A: Cytoprotection by prostaglandins. Gastroenterology 1979;77:761-767.
5. Robert A, Nezamis JE, Lancater C, Davis JP, Field SO, Hanchar AJ: Mild irritants prevent gastric necrosis through 'adaptive cytoprotection' mediated by prostaglandins. Am J Physiol 1983;245:G113-G121.
6. Konturek SJ, Radecki T, Brozozowski T, Drozdowics D, Piastucki I, Muramatsu M, Tanaka M. Aihara H: Antiulcer and gastroprotcctive effects of solon, a synthetic flavonoid derivative of sophoradin. Role of endogenous prostaglandins. Eur J Pharmacol 1986;125:185-192.
7. Kimura M, Saziki R, Arai I, Tarumoto Y, Nakane S: Effect of 2'-carboxymcthoxy-4,4'-bis(3-methyl-2-butenyloxy)chalcone on chronic gastric ulcers in rats. Jpn J Pharmacol 1984: 35:389-396.
8. Slomiany BL, Tamura S, Piotrowski J, Slomiany A: Effect of sofalcone administration on the physicochemical properties of gastric mucus. J Clin Gastroenterol 1992:14(suppl 1):S88-S93.
9. 2: Effect of sofalcone on rat gastric mucosa. Life Sci 1987;41:315-322.
10. 2 and mucosal protection in the rat. Pediatr Res 1992;31:193-195.
11. Dial EJ, Lichtenberger LM: Development of gastric mucosal protection against acid in the rat. Role of corticosteroids and prostaglandins. Gastroenterology 1986:91:318-325.
12. Kobayashi K, Arakawa T, Nakamura H, Chono S, Yamada H, Yamamoto S: Determination of prostaglandins and the effect of indo-methacin on rat gastric mucosa. Tohoku J Exp Med 1981:135:371-378.
13. Redfem JS, Lee E, Feldman M: Effect of indo-methacin on gastric mucosal prostaglandins in humans. Gastroenterology 1987;92:969-977.
14. Kerss S, Allen A, Gamer A: A simple method for measuring thickness of the mucus gel layer adherent to rat, frog, and human gastric mucosa: Influence of feeding, prostaglandin, N-ace-tylcysteine and other agents. Clin Sci 1982:63: 187-195.
15. Orihata M, Watanabe Y, Tanaka M, Okubo T, Sakakibara N: The relationship between adaptive cytoprotection and prostaglandin contents in the rat stomachs after oral administration of 0.35 N HC1. Scand J Gastroenterol 1989;24(suppl 162):79-82.
16. Hawkey CJ, Kemp RT, Walt RP, Bhaskar NK, Davies J, Filipowics B: Evidence that adaptive cytoprotection in rats is not mediated by prostaglandins. Gastroenterology 1988;94: 948-954.
17. McQueen S, Hutton D, Allen A, Gamer A: Gastric and duodenal surface mucus gel thickness in rat: Effect of prostaglandins and damaging agents. Am J Physiol 1983;245:G388-G393.
18. Wallace JL, McKnight GW: The mucoid cap over superficial gastric damage in the rat. Gastroenterology 1990,99:295-304.