Synthesis and in-vitro/in-vivo evaluation of orally administered entacapone prodrugs

Journal of Pharmacy and Pharmacology

Volumn 53, Issue 11, 2001, Pages 1489-1498

  Leppanen J ^a   Savolainen, J ^a   Nevalainen, T ^a   Forsberg, M ^a   Huuskonen, J ^a   Taipale, H ^a   Gynther, J ^b   Mannisto P T ^a   Jarvinen T ^b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b Finncovery Ltd   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL ESTER DERIVATIVE; ACYLOXY ETHER; ACYLOXYACYL ESTER DERIVATIVE; ALKYLOXYCARBONYL ESTER; CATECHOL METHYLTRANSFERASE INHIBITOR; DIPIVALOYL ESTER; ENTACAPONE; LEVODOPA; MONOPIVALOYL ESTER; PRODRUG; TOLCAPONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; DRUG BIOAVAILABILITY; DRUG DETERMINATION; DRUG HYDROLYSIS; DRUG RELEASE; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; EVALUATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; MALE; NONHUMAN; PARKINSON DISEASE; RAT; SERUM; STRUCTURE ANALYSIS;

ADMINISTRATION, ORAL; ANIMALS; ANTIPARKINSON AGENTS; BIOLOGICAL AVAILABILITY; CATECHOLS; ESTERS; ETHERS; HALF-LIFE; HUMANS; HYDROLYSIS; MALE; MEMBRANE LIPIDS; PRODRUGS; RATS; RATS, WISTAR; SOLUBILITY; WATER;

EID: 0035170117     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357011778025     Document Type: Article

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