Effects of the PAF receptor antagonist UK74505 on local and remote reperfusion injuries following ischaemia of the superior mesenteric artery in the rat

British Journal of Pharmacology

Volumn 131, Issue 8, 2000, Pages 1800-1808

  Souza, D G ^a   Cara, D C ^a   Cassali, G D ^a   Coutinho, S F ^a   Silveira, M R ^a   Andrade, S P ^a   Poole, S P ^b   Teixeira, M M ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

Ischaemia reperfusion; Mesenteric artery; Neutrophils; Oedema; PAF antagonist; TNF ; UK74505

Indexed keywords

BEPAFANT; FUCOIDIN; MODIPAFANT; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; HEART MUSCLE ISCHEMIA; HYPOTENSION; MALE; NEUTROPENIA; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SUPERIOR MESENTERIC ARTERY;

EID: 0034528005     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703756     Document Type: Article

References (34)

1. UK-74505, a novel and selective PAF antagonist, exhibits potent and long lasting activity in vivo
2. Zymosan-induced IL-8 release from human neutrophils involves activation via the CD11b/CD18 receptor and endogenous platelet-activating factor as an autocrine modulator
3. TCV-309, a novel platelet activating factor antagonist, inhibits leukocyte accumulation and protects against splanchnic artery occlusion shock
4. Platelet-activating factor mediates pulmonary macromolecular leak following intestinal ischaemia-reperfusion
5. Anti-adhesion therapy
6. Effects of tachykinin NK1- or PAF-receptor blockade on the lung injury induced by scorpion venom
7. TNFα potentiates oxidant and reperfusion-induced endothelial cell injury
8. Neutrophil chemoattractants generated in two phases during reperfusion of ischaemia myocardium in the rabbit: Evidence for a role for C5a and interleukin-8
9. Modipafant, a new PAF antagonist: Pharmacokinetics and disposition in rat, dog and man
10. Reperfused gut elaborates PAF that chemoattracts and primers neutrophils
11. Role of platelet-activating factor in ischaemia/reperfusion-induced leukocyte adherence
12. Therapeutic potential of inhibiting leukocyte rolling in ischaemia/reperfusion
13. Complement fragment-induced release of neutrophils from bone marrow and sequestration within pulmonary capillaries in rabbits
14. Effect of a novel potent platelet-activating factor antagonist, modipafant, in clinical asthma
15. The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusion
16. Fucoidin, but not yeast polyphosphomannan PPME, inhibits leukocyte rolling in venules of the rat mesentery
17. Platelet-activating factor antagonism: A new concept in the management of regional myocardial ischaemia-reperfusion injury
18. Therapeutic potential of platelet-activating factor antagonism in the management of myocardial infarction
19. Platelet-activating factor plays a pivotal role in the induction of experimental lung injury
20. Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice
21. Protective effects of polysaccharide fucoidin on myocardial ischaemia-reperfusion injury in rats
22. Pharmacological profile of UK-74,505, a novel and selective PAF antagonist with potent and prolonged oral activity
23. Two of the usual suspects, platelet-activating factor and its receptor, implicated in acute lung injury
24. Rat tumour necrosis factor-alpha: Expression in recombinant pichia pastoris, purification, characterization and development of a novel ELISA
25. Neutrophils accentuate renal cold ischaemia-reperfusion injury. Dose-dependent protective effect of a platelet-activating factor receptor antagonist
26. Fucoidin reduces coronary microvascular leukocyte accumulation early in reperfusion
27. Tumor necrosis factor: A master-regulator of leukocyte movement
28. Effects of a BLT receptor antagonist on local and remote reperfusion injuries after transient ischaemia of the superior mesenteric artery in rats
29. Lipid mediators, tumor necrosis factor and nitric oxide and their interactions in immune-complex-induced lung injury
30. The selectin binding polysaccharide fucoidin inhibits eosinophil recruitment in vivo
31. 1 integrins are critically involved in neutrophil locomotion in extravascular tissue in vivo
32. Pharmacologic approaches to reperfusion injury
33. Possible participation of intracellular platelet-activating factor in tumor necrosis factor-α production by rat peritoneal macrophages
34. The potential etiologic role of tumor necrosis factor in mediating multiple organ dysfunction in rats following intestinal ischaemia-reperfusion injury