Reexpression of a cluster of silenced transgenes is associated with their rearrangement

Genes Chromosomes and Cancer

Volumn 32, Issue 4, 2001, Pages 311-323

  McBurney, Michael W ^a   Lau, Stephen ^a   Jardine, Karen ^a   Yang, Xiaofeng ^a   Davies, Bryan ^a  

^a OTTAWA REGIONAL CANCER CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA METHYLATION; EMBRYO; GENE CLUSTER; GENE EXPRESSION; GENE INACTIVATION; GENE LOCUS; GENE REARRANGEMENT; GENE SEQUENCE; GENE SILENCING; GENETIC RECOMBINATION; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TANDEM REPEAT; TRANSGENE; TUMOR SUPPRESSOR GENE;

ANIMALS; AZACITIDINE; CLONE CELLS; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REARRANGEMENT; GENE SILENCING; LAC OPERON; MICE; MULTIGENE FAMILY; PHOSPHOGLYCERATE KINASE; RECOMBINANT FUSION PROTEINS; TRANSFECTION; TRANSGENES; TUMOR CELLS, CULTURED;

EID: 0035167232     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.1196     Document Type: Article

References (43)

1. Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter
2. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines
3. DNA methylation of two X chromosome genes in female somatic and embryonal carcinoma cells
4. Inhibition of herpes simplex thymidine kinase gene expression by bv DNA methylation viation is an indirect effect
5. Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene
6. Reactivation of silenced virally transduced genes by inhibitors of histone deacetylase
7. lacZ sequences prevent regulated expression of housekeeping genes
8. Demethylation of the progesterone receptor CpG island is not required for progesterone receptor gene expression
9. Promoter-region hypermethylation and gene silencing in human cancer
10. Reactivation of hprt on the inactive X chromosome with DNA demethylating agents
11. Cancer epigenetics comes of age
12. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
13. Effect of regional DNA methylation on gene expression
14. Simplified mammalian DNA isolation procedure
15. DNA methylation pattern of a tandemly repeated LacZ transgene indicates that most copies are silent
16. Thc (epi)genetic control of mammalian X-chromosome inactivation
17. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA
18. Inactive X chromosomal DNA docs not function in DNA-mediated cell transformation for the hypoxanthine phosphoribosyltransferase gene
19. Mcthylation of the hprt gene on the inactive X occurs after chromosome inactivation
20. Mechanisms of silencing in Saccharomyces cerevisiae
21. Suppression of crossing-over by DNA methylation in Ascobolus
22. Clonal lines of teratocarcinoma cells in vitro: Differentiation and cytogenetic characteristics
23. P19 embryonal carcinoma cells
24. Gene silencing in the development of cancer
25. The mouse Pgk-1 gene promoter contains an upstream activator sequence
26. The murine Pgk-1 promoter drives wide-spread but not uniform expression in transgenic mice
27. A role for RNA processing in regulating expression from transfected genes
28. Long-term silencing of retroviral vectors is resistant to reversal by trichostatin A and 5-azacytidine
29. Differential nuclear protein binding to 5-azacytosine-containing DNA as a potential mechanism for 5-aza-2′-deoxycytidine resistance
30. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
31. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
32. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
33. X chromosome reactivation in mouse embryonal carcinoma cells
34. Homologous recombination between transfected DNAs
35. Induced crossing-over in Drosophila melanogaster germ cells of DNA repair-proficient and repair-deficient (mei-9L1) males following laryal feeding with 5-azacytidine and mitomycin C
36. Cell culture methods and induction of differentiation of embryonal carcinoma cell lines
37. Genes transfected into embryonal carcinoma stem cells are both lost and inactivated at high frequency
38. Activation of the lac repressor in the transgenic mouse
39. DNA methylation: A molecular lock
40. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
41. A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells
42. The sins of the fathers and mothers: Genomic imprinting in mammalian development