Genetic alterations in patients with primary aldosteronism

Hypertension Research

Volumn 24, Issue 5, 2001, Pages 469-474

  Takeda, Y ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

CYP11B2 gene; Messenger RNA; Polymorphism; Primary aldosteronism

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; DNA; GLUCOCORTICOID; MESSENGER RNA; POTASSIUM ION; STEROID 11BETA MONOOXYGENASE;

ADRENAL CORTEX CARCINOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; CUSHING SYNDROME; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; HUMAN; HYPERTENSION; HYPOKALEMIA; IDIOPATHIC DISEASE; MONOCYTE; NONHUMAN; PRIMARY HYPERALDOSTERONISM; PROMOTER REGION; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SHORT SURVEY;

ALDOSTERONE SYNTHASE; HUMANS; HYPERALDOSTERONISM; POLYMORPHISM, GENETIC;

EID: 0035162688     PISSN: 09169636     EISSN: None     Source Type: Journal    
DOI: 10.1291/hypres.24.469     Document Type: Short Survey

References (50)

1. Hypertension caused by a truncated epithelial sodium channel gamma subunit: Genetic heterogeneity of Liddle syndrome
2. Several homozygous mutations in the gene for 11β-hydroxysteroid dehydrogenase type 2 in patients with apparent mineralocorticoid excess
3. Human hypertension caused by mutations in the kidney isozyme of 11β-hydroxysteroid dehydrogenase
4. Activating mineralocorticoid receptor mutations in hypertension exacerbated by pregnancy
5. A novel genetic locus for low renin hypertension: Familial hyperaldosteronism type II maps to chromosome 7 (7p22)
6. Mineralocorticoid hypertension
7. Urinary excretion of 19-noraldosterone, 18,19-dihydroxycorticosterone and 18-hydroxy-19-norcorticosterone in patients with aldosterone-producing adenoma or idiopathic hyperaldosteronism
8. Idiopathic hyperaldosteronism
9. Primary aldosteronism
10. The changing clinical spectrum of primary aldosteronism
11. Effects of corticotropin-releasing factor (CRF) on aldosterone and 18-hydroxycorticosterone in essential hypertension and primary aldosteronism
12. Predictive value of preoperative tests in discriminating bilateral adrenal hyperplasia from an aldosterone-producing adrenal adenoma
13. The unique steroidogenesis of the aldosteronoma in the differential diagnosis of primary aldosteronism
14. The significance of elevated levels of plasma 18-hydroxycorticosterone in patients with primary aldosteronism
15. The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex
16. Regulation of aldosterone synthase cytochrome P-450 in rat adrenals by angiotensin II and potassium
17. Plasma aldosterone and renin activity response to ACTH infusion in dexamethasone-suppressed normal and sodium depleted man
18. The acute and chronic effects of adrenocorticotropin on the levels of messenger ribonucleic acid and protein of steroidogenic enzymes in rat adrenal in vivo
19. Regulation of aldosterone synthase in human vascular endothelial cells by angiotensin II and adrenocorticotropin
20. Cardiac aldosterone production in genetically hypertensive rats
21. Genetic analysis of aldosterone synthase in patients with idiopathic hyperaldosteronism
22. Genetic analysis of the cytochrome P-450c17α (CYP17) and aldosterone synthase (CYP11B2) in Japanese patients with 17α-hydroxylase deficiency
23. Molecular variants in the P450c11AS gene as determinants of aldosterone synthase activity in the Dahl rat model of hypertension
24. Artificial mutations in P450c11AS (aldosterone synthase) can increase enzymatic activity: A model for low-renin hypertension?
25. Genetic variation in P450c11AS in Chilean patients with low renin hypertension
26. A chimeric 11β-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension
27. Primary aldosteronism-some genetic, morphological, and biochemical aspects of subtypes
28. Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol
29. Aldosterone-producing adenomas do not contain glucocorticoid-remediable aldosteronism chimeric gene duplications
30. A new test for familial hyperaldosteronism type I aids in the detection of curable hypertension
31. Diagnosis of glucocorticoid-remediable aldosteronism in primary aldosteronism: Aldosterone response to dexamethasone and long polymerase chain reaction for chimeric gene
32. Primary aldosteronism: A new understanding
33. G protein gene mutations in patients with multiple endocrinopathies
34. Mutations in CYP11B1 gene converting 11β-hydroxylase into an aldosterone-producing enzyme are not present in aldosterone-producing adenomas
35. Adrenal incidentaloma and patients with homozygous or heterozygous congenital adrenal hyperplasia
36. Steroid 21-hydroxylase mutations and 21-hydroxylase messenger ribonucleic acid expression in human adrenocortical tumors
37. Zona fasciculata-like cells determine the response of plasma aldosterone to metoclopramide and aldosterone synthase messenger ribonucleic acid level in aldosterone-producing adenoma
38. Aldosterone synthesis in the hearts of stroke-prone spontaneously hypertensive rats
39. Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 (IL-4)m IL5, and γ-interferon, but not IL-2 by activated murine T cells
40. Estrogen biosynthesis in THP1 cells is regulated by promoter switching of the aromatase (CYP19) gene
41. Synthesis of 19-noraldosterone, 18-hydroxy-19-norcorticos-teorne and 18,19-dihydroxycorticosterone in the human aldosterone-producing adenoma
42. Structural analysis and evaluation of the aldosterone synthase gene in hypertension
43. Associations between aldosterone synthase gene polymorphism and the adrenocortical function in males
44. Haplotype analysis of CYP11B2
45. Angiotensin II and potassium regulate human CYP11B2 transcription through common cis-elements
46. 173 Arg and -344T/C variants of CYP11B2 in Japanese patients with low-renin hypertension
47. Aldosterone synthase gene in patients suffering from hyperaldosteronism
48. Idiopathic hyperaldosteronism: Analysis of aldosterone synthase gene
49. CYP11B2 gene polymorphisms in idiopathic hyperaldosteronism
50. Lack of association between genetic polymorphism of CYP11B2 and hypertension in Japanese