Reciprocal regulation of cyclic GMP content by cyclic GMP-phosphodiesterase and guanylate cyclase in SHR with CsA-induced nephrotoxicity

British Journal of Pharmacology

Volumn 134, Issue 5, 2001, Pages 995-1002

  Hosogai, N ^a   Seki, J ^a   Goto, T ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Cyclic GMP; Cyclic GMP phosphodiesterase; Cyclosporin A; Guanylate cyclase; Nephrotoxicity; NO synthase

Indexed keywords

CYCLIC GMP; CYCLIC GMP PHOSPHODIESTERASE; CYCLOSPORIN; GUANYLATE CYCLASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CREATININE CLEARANCE; DRUG EFFECT; ENZYME ACTIVITY; ISOLATED KIDNEY; KIDNEY PERFUSION; MALE; NEPHROTOXICITY; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; RAT; SODIUM EXCRETION; SPONTANEOUSLY HYPERTENSIVE RAT; UREA NITROGEN BLOOD LEVEL;

EID: 0035160554     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704337     Document Type: Article

References (34)

1. Cyclosporin nephrotoxicity: Pathophysiology and comparison with FK-506
2. Protective effects of dietary L-arginine supplementation on chronic cyclosporine nephrotoxicity
3. L-Arginine and allopurinol protect against cyclosporine nephrotoxicity
4. Cyclosporine A up-regulates angiotensin II receptors and calcium responses in human vascular smooth muscle cells
5. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
6. Low nitric oxide production in patients with chronic renal failure
7. Role of NO in cyclosporin nephrotoxicity: Effects of chronic NO inhibition and NO synthases gene expression
8. Atrial natriuretic peptide blunts the cellular effects of cyclosporine in smooth muscle
9. Renal endothelial and macula densa NOS: Integrated response to changes in extracellular fluid volume
10. Increased nitrovasodilator sensitivity in endothelial nitric oxide synthase knockout mice: Role of soluble guanylyl cyclase
11. Chronic cyclosporine therapy impairs endothelium-dependent relaxation in the renal artery of the rat
12. Expression of endothelial and inducible nitric oxide synthase in human glomerulonephritis
13. 2+
14. Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases
15. Activation of guanylate cyclase from rat liver and other tissues by sodium azide
16. Biosynthesis and homeostatic roles of nitric oxide in the normal kidney
17. Atrial natriuretic factor improves renal function and lowers systolic blood pressure in renal allograft recipients treated with cyclosporin A
18. Soluble guanylate cyclase gene expression and localization in rat lung after exposure to hypoxia
19. Pleiotropic regulation of vascular smooth muscle tone by cyclic GMP-dependent protein kinase
20. Role of reactive oxygen species in the signalling cascade of cyclosporine A-mediated up-regulation of eNOS in vascular endothelial cells
21. Effect of cyclosporin A and analogues on cytosolic calcium and vasoconstriction: Possible lack of relationship to immunosuppressive activity
22. Dihydrotestosterone is the active androgen in the maintenance of nitric oxide mediated penile erection in the rat
23. Contribution of phosphodiesterase isoenzymes and cyclic nucleotide efflux to the regulation of cyclic GMP levels in aortic smooth muscle cells
24. Cellular mechanisms of cyclosporine A-associated side-effects: Role of endothelin
25. Related articles cyclosporine nephrotoxicity
26. Transcriptional induction of endothelial nitric oxide gene by cyclosporine A. A role for activator protein-1
27. Role of nitric oxide in cyclosporine A-induced hypertension
28. Role of endothelin ET(A) receptors in the hypertension produced by 4-day L-nitroarginine methyl ester and cyclosporine treatment
29. Nephrotoxicity of cyclosporine in spontaneously hypertensive rats: Effects on blood pressure and vascular lesions
30. Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis
31. Multiple cyclic nucleotide phosphodiesterase activities from rat brain
32. Depressed renal and vascular nitric oxide synthase expression in cyclosporine-induced hypertension
33. Role of macula densa NOS in tubuloglomerular feedback
34. Cyclosporin A increases hypoxia and free radical production in rat kidneys: Prevention by dietary glycine