Eye tracking disorder in schizophrenia is characterized by specific ocular motor defects and is associated with the deficit syndrome

Biological Psychiatry

Volumn 42, Issue 9, 1997, Pages 781-796

  Ross, David E ^a   Thaker, Gunvant K ^a   Buchanan, Robert W ^a   Kirkpatrick, Brian ^a   Lahti, Adrienne C ^a   Medoff, Deborah ^a   Bartko, John J ^a   Goodman, Jason ^a   Tien, Allen ^b  

^a UNIVERSITY OF MARYLAND   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Eye movements; Mixture analysis; Saccades; Schizophrenia; Smooth pursuit

Indexed keywords

ADULT; ARTICLE; DISEASE ASSOCIATION; EYE TRACKING; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTOR ACTIVITY; NEGATIVE SYNDROME; OCULOGRAPHY; OPHTHALMOPLEGIA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; SCHIZOPHRENIA; SMOOTH PURSUIT EYE MOVEMENT;

ADULT; ATTENTION; CEREBRAL CORTEX; ELECTROOCULOGRAPHY; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE NET; OCULAR MOTILITY DISORDERS; PSYCHIATRIC STATUS RATING SCALES; PURSUIT, SMOOTH; SACCADES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 0030727745     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(96)00492-1     Document Type: Article

References (72)

1. Diagnostic and Statistical Manual of Mental Disorders. 3rd ed rev. 1987;American Psychiatric Press, Washington, DC.
2. Abel LA, Ziegler AS. Smooth pursuit eye movements in schizophrenics - What constitutes assessment? Biol Psychiatry. 24:1988;746-761.
3. Abel LA, Friedman L, Jesberger JA, Malki A, Meltzer HY. Quantitative assessment of smooth pursuit gain and catch-up saccades in schizophrenia and affective disorders. Biol Psychiatry. 29:1991;1063-1072.
4. Andreasen N. The Scale for the Assessment of Negative Symptoms (SANS) Conceptual and Theoretical Foundations . Br J Psychiatry. 155:1989;49-52.
5. Bahill A, McDonald J. Frequency limitations and optimal step size for the two-point central difference derivate algorithm with applications to human eye movement data. IEEE Trans Biomed Eng. 3:1983;191-194.
6. Bahill A, Clark M, Stark L. The main sequence, a tool for studying human eye movements. Math Biosci. 24:1975;191-204.
7. Blackwood D, Clair DS, Muir W, Duffy J. Auditory P300 and eye tracking dysfunction in schizophrenic pedigrees. Arch Gen Psychiatry. 48:1991;899-909.
8. Buchanan R, Carpenter W. Domains of psychopathology An approach for the reduction of heterogeneity in schizophrenia . J Nerv Ment Dis. 182:1994;193-204.
9. Buchanan R, Kirkpatrick B, Heinrichs D, Carpenter W. Clinical correlates of the deficit syndrome of schizophrenia. Am J Psychiatry. 147:1990;290-294.
10. Buchanan R, Breier A, Kirkpatrick B, et al. Structural abnormalities in deficit and nondeficit schizophrenia. Am J Psychiatry. 150:1993;59-65.
11. Campion D, Thibaut F, Denise P, Courtin P, Pottier M, Levillain D. SPEM impairment in drug-naive schizophrenic patients Evidence for a trait marker . Biol Psychiatry. 32:1992;891-902.
12. Carpenter W, Buchanan R. Domains of psychopathology relevant to the study of etiology and treatment in schizophrenia. Schulz S, Tamminga C. Schizophrenia Scientific Progress . 1989;13-22 Oxford Press, New York.
13. Carpenter W, Heinrichs D, Wagman A. Deficit and nondeficit forms of schizophrenia The concept . Am J Psychiatry. 145:1988;578-583.
14. Carpenter W, Buchanan R, Kirkpatrick B, Tamminga C, Wood F. Strong inference, theory testing and the neuroanatomy of schizophrenia. Arch Gen Psychiatry. 50:1993;825-831.
15. Clementz BA, Sweeney JA, Hirt M, Haas G. Pursuit gain and saccadic intrusions in first-degree relatives of probands with schizophrenia. J Abnorm Psychol. 99:1990;327-335.
16. Clementz BA, Grove WM, Iacono WG, Sweeney JA. Smooth-pursuit eye movement dysfunction and liability for schizophrenia Implications for genetic modeling . J Abnorm Psychol. 101:1992;117-129.
17. Cohen J. Statistical Power Analysis. 1988;Erlbaum, Hillsdale, NJ.
18. Dodge R. Five types of eye movement in the horizontal meridian plane of the field of regard. Am J Physiol. 8:1903;307-329.
19. Fenton W, McGlashan T. Antecedents, symptom progression, and long-term outcome of the deficit syndrome in schizophrenia. Am J Psychiatry. 151:1994;351-356.
20. Friedman L, Jesberger JA, Meltzer HY. A model of smooth pursuit performance illustrates the relationship between gain, catch-up saccade rate, and catch-up saccade amplitude in normal controls and patients with schizophrenia. Biol Psychiatry. 30:1991;537-556.
21. Friedman L, Abel L, Jesberger J, Malki A, Meltzer H. Saccadic intrusions into smooth pursuit in patients with schizophrenia or affective disorders and normal controls. Biol Psychiatry. 31:1992;1110-1118.
22. Friedman L, Jesberger JA, Meltzer HY. Effect of typical antipsychotic medications and clozapine on smooth pursuit performance in patients with schizophrenia. Psychiatry Res. 41:1992;25-36.
23. Friedman L, Jesberger J, Siever L, Thompson P, Mohs R, Meltzer H. Smooth pursuit performance in patients with affective disorders or schizophrenia and normal controls Analysis with specific oculomotor measures, RMS error and qualitative ratings . Psychol Med. 25:1995;387-403.
24. Gelenberg A, Bassuk E, Schoonover S. The Practitioner's Guide to Psychoactive Drugs. 1991;Plenum Medical Book Company, New York.
25. Gibbons R, Dorus E, Ostrow D, Pandez G, Davis J, Levy D. Mixture distributions in psychiatric research. Biol Psychiatry. 19:1984;935-961.
26. Goldreich D, Krauzlis R, Lisberger S. Effect of changing feedback delay on spontaneous oscillations in smooth pursuit eye movements of monkeys [published erratum appears in J Neurophysiol 1992;68(1), following table of contents]. J Neurophysiol. 67:1992;625-638.
27. Grove WM, Lebow BS, Clementz BA, Cerri A, Medus C, Iacono WG. Familial prevalence and co-aggregation of schizotypy indicators A multitrait family study . J Abnorm Psychol. 100:1991;115-121.
28. Hollingshead A, Redlich S. Social Class and Mental Illness A Community Study . 1988;Wiley, New York.
29. Iacono W, Clementz B. A strategy for elucidating genetic influences on complex psychopathological syndromes (with special reference to ocular motor functioning in schizophrenia). Chapman L, Chapman J, Fowles D. Progress in Experimental Personality and Psychopathology Research Models and Methods of Psychopathology . 1993;11-65 Springer, New York.
30. Iacono WG, Moreau M, Beiser M, Fleming JA, Lin TY. Smooth-pursuit eye tracking in first-episode psychotic patients and their relatives. J Abnorm Psychol. 101:1992;104-116.
31. Katsanis J, Iacono W. Clinical, neuropsychological, and brain structural correlates of smooth-pursuit eye tracking performance in chronic schizophrenia. J Abnorm Psychol. 100:1991;526-534.
32. Keefe R, Siever L, Mohs R, et al. Eye tracking, schizophrenic symptoms, and schizotypal personality disorder. Eur Arch Psychiatry Neurol Sci. 239:1989;39-42.
33. Kelly P, Rennie C, Gordon E, Anderson J, Howson A, Meares R. Smooth pursuit eye tracking dysfunction and negative symptoms in schizophrenia. Psychiatry Res. 34:1990;89-97.
34. Kendler K, Ochs A, Gorman A, Hewitt J, Ross D, Mirsky A. The structure of schizotypy A pilot multitrait twin study . Psychiatry Res. 36:1991;19-36.
35. Kirkpatrick B, Buchanan R. Anhedonia and the deficit syndrome of schizophrenia. Psychiatry Res. 31:1989;25-30.
36. Kirkpatrick B, Buchanan RW, McKenney PD, Alphs LD, Carpenter WT. The Schedule for the Deficit Syndrome An instrument for research in schizophrenia . Psychiatry Res. 30:1989;119-123.
37. Leigh RJ, Zee DS. The Neurology of Eye Movements. 1991;FA Davis Company, Philadelphia.
38. Levin S, Luebke A, Zee DS, Hain TC, Robinson DA, Holzman PS. Smooth pursuit eye movements in schizophrenics Quantitative measurements with the search-coil technique . J Psychiatr Res. 22:1988;195-206.
39. Levy D, Holzman P, Matthysse S, Mendell N. Eye tracking dysfunction and schizophrenia A critical perspective . Schizophr Bull. 19:1993;461-505.
40. Lieberman J, Jody D, Alvir J, et al. Brain morphology, dopamine and eye tracking in first episode schizophrenia. Prevalence and clinical correlates. Arch Gen Psychiatry. 50:1993;357-368.
41. Lisberger SG, Morris EJ, Tychsen L. Visual motion processing and sensory-motor integration for smooth pursuit eye movements. Annu Rev Neurosci. 10:1987;97-129.
42. Luebke AE, Robinson DA. Transition dynamics between pursuit and fixation suggest different systems. Vision Res. 28:1988;941-946.
43. MacLean C, Morton N, Elston R, Yee S. Skewness in commingling distributions. Biometrics. 32:1976;695-699.
44. Mather JA, Neufeld RWJ, Merskey H, Russell NC. Disruption of saccade production during oculomotor tracking in schizophrenia and the use of its changes across target velocity as a discriminator of the disorder. Psychiatry Res. 43:1992;93-109.
45. McGue M, Gerrard J, Lebowitz M, Rao D. Commingling in the distributions of immunoglobin levels. Hum Hered. 39:1989;196-201.
46. Moser A, Kompf A, Arolt V, Resch T. Quantitative analysis of eye movements in schizophrenia. Neuro-ophthalmology. 10:1990;73-80.
47. Overall J, Gorman D. The brief psychiatric rating scale in psychopharmacologic research. Psychol Res. 10:1961;799-812.
48. Pfohl B, Blum N, Zimmerman M, Stangl D. Structured Interview for DSM-III-R Personality (SIDP-R). 1989;University of Iowa Department of Psychiatry, Iowa City, IA.
49. Radant AD, Hommer DW. A quantitative analysis of saccades and smooth pursuit during visual pursuit tracking A comparison of schizophrenics with normals and substance abusing controls . Schizophr Res. 6:1992;225-235.
50. Rashbass C. The relationship between saccadic and smooth tracking eye movements. J Physiol. 159:1961;326-338.
51. Robinson D. The mechanics of human smooth pursuit eye movement. J Physiol. 180:1965;569-591.
52. Robinson DA, Gordon JL, Gordon SE. A model of the smooth pursuit eye movement system. Biol Cybern. 55:1986;43-57.
53. Ross DE, Ochs AL, Hill MP, Goldberg SC, Pandurangi AK, Winfrey J. The erratic nature of eye movements in schizophrenic patients as revealed by high resolution techniques. Biol Psychiatry. 24:1988;675-688.
54. Ross DE, Thaker GK, Holcomb HH, Cascella NG, Medoff DR, Tamminga CA. Abnormal smooth pursuit eye movements in schizophrenic patients are associated with cerebral glucose metabolism in oculomotor regions. Psychiatry Res. 58:1995;53-67.
55. Ross DE, Ochs AL, Pandurangi AK, Thacker LR, Kendler KS. Mixture analysis of smooth pursuit eye movements in schizophrenia. Psychophysiology. 33:1996;390-397.
56. Ross DE, Thaker GK, Buchanan RW, et al. Association of abnormal smooth pursuit eye movements with the deficit syndrome in schizophrenic patients. Am J Psychiatry. 153:1996;1158-1165.
57. Schmid-Burgk W, Becker W, Diekmann V, Jurgens R, Kornhuber HH. Disturbed smooth pursuit and saccadic eye movements in schizophrenia. Arch Psychiatry Neurol Sci. 232:1982;381-389.
58. Schooler N, Kane J. Research diagnoses for tardive dyskinesia. Am J Psychiatry. 39:1982;486-487.
59. Siever LJ, Haier RJ, Coursey RD, et al. Smooth pursuit eye tracking impairment Relation to other 'markers' of schizophrenia and psychologic correlates . Arch Gen Psychiatry. 39:1982;1001-1005.
60. Siever LJ, Coursey RD, Alterman IS, Buchsbaum M, Murphy DL. Impaired smooth pursuit eye movement Vulnerability marker for schizotypal personality disorder in a normal volunteer population . Am J Psychiatry. 141:1984;1560-1566.
61. Siever L, Keefe R, Bernstein D, et al. Eye tracking impairment in clinically identified patients with schizotypal personality disorder. Am J Psychiatry. 147:1990;740-745.
62. Siever L, Friedman L, Moskowitz J, et al. Eye movement impairment and schizotypal psychopathology. Am J Psychiatry. 151:1994;1209-1215.
63. Simons R, Katkin W. Smooth pursuit eye movements in subjects reporting physical anhedonia and perceptual aberrations. Psychiatry Res. 14:1985;275-289.
64. Sweeney J, Haas G, Li S. Neuropsychological and eye movement abnormalities in first-episode and chronic schizophrenia. Schizophr Bull. 18:1992;283-293.
65. Sweeney J, Clementz B, Escobar M, Li S, Pauler D, Haas G. Mixture analysis of pursuit eye-tracking dysfunction in schizophrenia. Biol Psychiatry. 34:1993;331-340.
66. Sweeney J, Haas G, Clementz B, Escobar M, Drake K, Francis A. Eye tracking dysfunction in schizophrenia Characterization of component eye movement abnormalities, diagnostic specificity and the role of attention . J Abnorm Psychol. 103:1994;222-230.
67. Tamminga CA, Thaker GK, Buchanan R, et al. Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome. Arch Gen Psychiatry. 49:1992;522-530.
68. Thaker G, Cassady S, Adami H, Moran M, Ross D. Eye movements in spectrum personality disorders Comparison of a community sample with relatives of schizophrenic patients . Am J Psychiatry. 153:1996;362-368.
69. Thaker GK, Ross DE, Moran MJ, Lahti A, Buchanan R, Ellsberry RL. Does pursuit abnormality in schizophrenia represent a deficit in the predictive mechanism? Psychiatry Res. 159:1996;221-237.
70. Thaker G, Kirkpatrick B, Buchanan RW, Ellsberry R, Lahti A, Tamminga C. Oculomotor abnormalities and their clinical correlates in schizophrenia. Psychopharmacol Bull. 25:1989;491-497.
71. Thode H, Finch S, Mendell N. Simulated percentage points of the likelihood ratio tests for the mixture of two normals. Biometrics. 44:1988;1195-1201.
72. Wagman A, Heinrichs D, Carpenter W. Deficit and non-deficit forms of schizophrenia Neuropsychological evaluation . Psychiatry Res. 22:1987;319-330.