Sibling correlation of deficit syndrome in the Irish Study of High- Density Schizophrenia Families

American Journal of Psychiatry

Volumn 157, Issue 7, 2000, Pages 1071-1076

  Ross, David E ^a   Kirkpatrick, Brian ^b   Karkowski, Laura M ^b   Straub, Richard E ^b   MacLean, Charles J ^b   O'Neill, F Anthony ^b   Compton, Amelia D ^b   Murphy, Bernadette ^b   Walsh, Dermot ^b   Kendler, Kenneth S ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CORRELATION FUNCTION; ENVIRONMENTAL FACTOR; FAMILY STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEGATIVE SYNDROME; PRIORITY JOURNAL; REGRESSION ANALYSIS; SCHIZOPHRENIA; SIBLING; UNITED KINGDOM;

ADULT; FAMILY; FEMALE; HUMANS; IRELAND; LOGISTIC MODELS; MALE; PHENOTYPE; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; REGRESSION ANALYSIS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 0033945423     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.157.7.1071     Document Type: Article

References (54)

1. Straub RE, MacLean CJ, O'Neill FA, Burke J, Murphy B, Duke F, Shinkwin R, Webb BT, Zhang J, Walsh D, Kendler KS: A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nat Genet 1995; 11:287-293
2. Blouin J-L, Dombroski B, Nath SK, Lasseter VK, Wolyniec PS, Nestadt G, Thornquist M, Ullrich G, McGrath J, Kasch L, Lamacz M, Thomas MG, Gehrig C, Radhakrishna U, Snyder SH, Balk KG, Neufeld K, Swartz KL, DeMarchi N, Papadimitriou GN, Dikeos DG, Stefanis CN, Chakravarti A, Childs B, Housman DE, Kazazian HH, Antonarakis SE, Pulver AE: Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet 1998; 20: 70-73
3. Faraone SV, Matise T, Svrakic D. Pepple J, Malaspina D, Suarez B, Campe C, Kambuto CT, Schmitt K, Meyer J, Markel P, Zee H, Friedman JMH, Shore D, Moldin S, Wynne D, Kaufmann C, Cloninger CR, Tsuang MT: A genome scan of the European-American schizophrenia pedigrees of the NIMH Genetics Initiative. Neuropsychiatr Genet 1998; 81:290-295
4. Kendler KS: Molecular genetics of schizophrenia, in Neurobiology of Mental Illness. Edited by Charney DS, Nestler EJ, Bunney BS. New York, Oxford University Press, 1999, pp 203-213
5. Chen WJ, Faraone SV, Tsuang MT: Linkage studies of schizophrenia: a simulation study of statistical power. Genet Epidemiol 1992; 9:123-139
6. Levinson DF: Power to detect linkage with heterogeneity in samples of small nuclear families. Am J Med Genet Neuropsychiatr Genet 1993; 48:94-102
7. Martinez MM, Goldin LR: The detection of linkage and heterogeneity in nuclear families for complex disorders: one versus two marker loci. Am J Hum Genet 1989; 44:552-559
8. Kendler KS, Diehl SR: The genetics of schizophrenia: a current, genetic-epidemiologic perspective. Schizophr Bull 1993; 19: 261-285
9. Kraepelin E: Dementia Praecox and Paraphrenia (1919). Translated by Barclay RM; edited by Robertson GM. New York, Robert E Krieger, 1971
10. Carpenter WT Jr, Heinrichs DW, Wagman AM: Deficit and non-deficit forms of schizophrenia: the concept. Am J Psychiatry 1988; 145:578-583
11. Kirkpatrick B, Buchanan RW, McKenney PD, Alphs LD, Carpenter WT Jr: The Schedule for the Deficit Syndrome: an instrument for research in schizophrenia. Psychiatry Res 1989; 30: 119-123
12. Dollfus S, Ribeyre JM, Petit M: Family history and deficit form in schizophrenia. Eur Psychiatry 1996; 1:260-267
13. Waltrip RW II, Buchanan RW, Carpenter WT Jr, Kirkpatrick B, Summerfelt A, Breier A, Rubin SA, Carbone DM: Borna disease virus antibodies and the deficit syndrome of schizophrenia. Schizophr Res 1997; 23:253-257
14. Kirkpatrick B, Ram R, Amador XF, Buchanan RW, McGlashan T, Tonen M, Bromet E: Summer birth and the deficit syndrome of schizophrenia. Am J Psychiatry 1998; 155:1221-1226
15. Fenton WS, McGlashan TH: Testing systems for assessment of negative symptoms in schizophrenia. Arch Gen Psychiatry 1992; 49:179-184
16. Kirkpatrick B, Buchanan R, Breier A, Carpenter WT Jr: Case identification and stability of the deficit syndrome of schizophrenia. Psychiatry Res 1993; 47:47-56
17. Fenton WS, McGlashan TH: Antecedents, symptom progression, and long-term outcome of the deficit syndrome in schizophrenia. Am J Psychiatry 1994; 151:351-356
18. Kirkpatrick B, Buchanan RW, Breier A, Carpenter WT Jr: Depressive symptoms and the deficit syndrome of schizophrenia. J Nerv Ment Dis 1994; 182:452-455
19. Kirkpatrick B, Amador XF, Flaum M, Yale SA, Gorman JM, Carpenter WT Jr, Tohen M, McGlashan T: The deficit syndrome in the DSM-IV field trial, I: alcohol and other drug abuse. Schizophr Res 1996; 20:69-77
20. Kirkpatrick B, Ram R, Bromet E: The deficit syndrome in the Suffolk County Mental Health Project. Schizophr Res 1996; 22: 119-126
21. Amador XF, Kirkpatrick B, Buchanan RW, Carpenter WT, Marcinko L, Yale SA: Stability of the diagnosis of deficit syndrome in schizophrenia. Am J Psychiatry 1999; 156:637-639
22. Buchanan RW, Kirkpatrick B, Heinrichs DW, Carpenter WT Jr: Clinical correlates of the deficit syndrome of schizophrenia. Am J Psychiatry 1990; 147:290-294
23. Tamminga CA, Thaker GK, Buchanan R, Kirkpatrick B, Alphs LD, Chase TN, Carpenter WT Jr: Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome. Arch Gen Psychiatry 1992; 49:522-530
24. Buchanan RW, Breier A, Kirkpatrick B, Elkashef A, Munson RC, Gellad F, Carpenter WT Jr: Structural abnormalities in deficit and nondeficit schizophrenia. Am J Psychiatry 1993; 150:59-65
25. Lahti AC, Holcomb HH, Carpenter WT, Zhao M, Buchanan RW, Tamminga CA: Blood flow activation differences during an auditory task in schizophrenic patients with and without primary negative symptoms (abstract). Schizophr Res 1997; 24: 167
26. Thaker G, Kirkpatrick B, Buchanan RW, Ellsberry R, Lahti A, Tamminga C: Oculomotor abnormalities and their clinical correlates in schizophrenia Psychopharmacol Bull 1989; 25: 491-497
27. Buchanan R, Strauss M, Kirkpatrick B, Holstein C, Breier A, Carpenter W: Neuropsychological impairments in deficit vs non-deficit forms of schizophrenia. Arch Gen Psychiatry 1994; 51: 804-811
28. Ross DE, Thaker GK, Buchanan RW, Lahti AC, Medoff D, Bartko JJ, Moran M, Hartley J: Association of abnormal smooth pursuit eye movements with the deficit syndrome in schizophrenic patients. Am J Psychiatry 1996; 153:1158-1165
29. Buchanan RW, Strauss ME, Breier A, Kirkpatrick B, Carpenter WT Jr: Attentional impairments in deficit and nondeficit forms of schizophrenia. Am J Psychiatry 1997; 154:363-370
30. Bustillo JR, Thaker G, Buchanan RW, Moran M, Kirkpatrick B, Carpenter WT Jr: Visual information-processing impairments in deficit and nondeficit schizophrenia. Am J Psychiatry 1997; 154:647-654
31. Ross DE, Thaker GK, Buchanan RW, Kirkpatrick B, Lahti AC, Medoff D, Bartko JJ, Goodman J, Tien AY: Eye tracking disorder in schizophrenia is characterized by specific ocular motor defects and is associated with the deficit syndrome. Biol Psychiatry 1997; 42:781-796
32. Breier A, Buchanan RW, Kirkpatrick B, Davis OR, Irish D, Summerfelt A, Carpenter WT Jr: Effects of clozapine on positive and negative symptoms in outpatients with schizophrenia. Am J Psychiatry 1994; 151:20-26
33. Kopelowicz A, Liberman RP, Mintz J, Zarate R: Comparison of efficacy of social skills training for deficit and nondeficit negative symptoms in schizophrenia. Am J Psychiatry 1997; 154: 424-425
34. Kirkpatrick B, Ross DE, Walsh D, Karkowski L, Kendler KS: Family characteristics of deficit and nondeficit schizophrenia in the Roscommon Family Study. Schizophr Res (in press)
35. lacono W, Clementz B: A strategy for elucidating genetic influences on complex psychopathological syndromes (with special reference to ocular motor functioning in schizophrenia), in Progress in Experimental Personality and Psychopathology Research: Models and Methods of Psychopathology. Edited by Chapman L, Chapman J, Fowles D. New York, Springer, 1993, pp 11-65
36. Levy D, Holzman P, Matthysse S, Mendell N: Eye tracking dysfunction and schizophrenia: a critical perspective. Schizophr Bull 1993; 19:461-505
37. Arolt V, Lencer R, Nolte A, Muller-Myhsok B, Purmann S, Schurmann M, Leutelt J, Pinnow M, Schwinger E: Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease. Am J Med Genet 1996; 67:564-579
38. Kendler KS, O'Neill FA, Burke J, Murphy B, Duke F, Straub RE, Shinkwin R, Ni Nuallain M, MacLean CJ, Walsh D: Irish study of high-density schizophrenia families: field methods and power to detect linkage. Am J Med Genet 1996; 67:179-190
39. Spitzer RL, Williams JBW, Gibbon M: Structured Clinical Interview for DSM-III-R (SCID). New York, New York State Psychiatric Institute, Biometrics Research, 1987
40. Kendler KS, Lieberman JA, Walsh D: The Structured Interview for Schizotypy (SIS): a preliminary report. Schizophr Bull 1989; 15:559-571
41. Kendler KS, McGuire M, Gruenberg AM, Walsh D: An epidemiologic, clinical, and family study of simple schizophrenia in County Roscommon, Ireland. Am J Psychiatry 1994; 151:27-34
42. Kendler KS, McGuire M, Gruenberg AM, O'Hare A, Spellman M, Walsh D: The Roscommon Family Study, I: methods, diagnosis of probands, and risk of schizophrenia in relatives. Arch Gen Psychiatry 1993; 50:527-540
43. Kendler KS, Karkowski-Shuman L, O'Neill FA. Straub RE, MacLean CJ, Walsh D: Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish Study of High-Density Schizophrenia Families: evidence for possible etiologic heterogeneity. Am J Psychiatry 1997; 154:191-198
44. Burke JG, Murphy BM, Bray JC, Walsh D, Kendler KS: Clinical similarities in siblings with schizophrenia. Am J Med Genet 1996; 67:239-243
45. Hwu HG, Wu YC, Lee SF. Yeh LL, Gwo SC, Hsu HC, Chang CJ, Chen WJ: Concordance of positive and negative symptoms in coaffected sib-pairs with schizophrenia. Am J Med Genet 1997; 74:1-6
46. Dworkin RH, Lenzenweger MF: Symptoms and the genetics of schizophrenia: implications for diagnosis. Am J Psychiatry 1984; 141:1541-1546
47. Dworkin RH, Lenzenweger MF, Moldin SO, Skillings GF, Levick SE: A multidimensional approach to the genetics of schizophrenia, Am J Psychiatry 1988; 145:1077-1083
48. DeLisi LE, Goldin LR, Maxwell E, Kazuba DM, Gershon ES: Clinical features of illness in siblings with schizophrenia or schizoaffective disorder. Arch Gen Psychiatry 1987; 44:891-896
49. Verdoux H, van Os J, Sham P, Jones P, Gilvarry K, Murray R: Does familiality predispose to both emergence and persistence of psychosis? a follow-up study. Br J Psychiatry 1996; 168:620-662; correction, 169:116
50. Van Os J, Marcelis M, Sham P, Jones P, Gilvarry K, Murray R: Psychopathological syndromes and familial morbid risk of psychosis. Br J Psychiatry 1997; 170:241-246
51. Kendler KS, McGuire M, Gruenberg AM, Walsh D: Clinical heterogeneity in schizophrenia and the pattern of psychopathology in relatives: results from an epidemiologically based family study. Acta Psychiatr Scand 1994; 89:294-300
52. Straub RE, MacLean CJ, O'Neill FA, Walsh D, Kendler KS: Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish families. Mol Psychiatry 1997; 2:148-155
53. Kendler KS, MacLean CJ, O'Neill FA, Burke J, Murphy B, Duke F, Shinkwin R, Easter SM, Webb BT, Zhang J, Walsh D, Straub RE: Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families. Am J Psychiatry 1996; 153:1534-1540
54. Straub RE, MacLean CJ, Martin RB, Ma Y, Myakishev MV, Harris-Kerr C, Webb BT, O'Neill FA, Walsh D, Kendler KS: A schizophrenia locus may be located in region 10p15-p11. Am J Med Genet Neuropsychiatr Genet 1998; 81:296-301