Association of abnormal smooth pursuit eye movements with the deficit syndrome in schizophrenic patients

American Journal of Psychiatry

Volumn 153, Issue 9, 1996, Pages 1158-1165

  Ross, David E ^a,b   Thaker, Gunvant K ^a   Buchanan, Robert W ^a   Lahti, Adrienne C ^a   Medoff, Deborah ^a   Bartko, John J ^a   Moran, Marianne ^a   Hartley, Julie ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; HUMAN; HYPOTHESIS; INFRARED RADIATION; MAJOR CLINICAL STUDY; NEGATIVE SYNDROME; OCULOGRAPHY; PREDICTION; PRIORITY JOURNAL; SCHIZOPHRENIA; SMOOTH PURSUIT EYE MOVEMENT; STEADY STATE;

EID: 0029762045     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.153.9.1158     Document Type: Article

References (42)

1. Levy D, Holzman P, Marthyssc S, Mendell N: Eye tracking and schizophrenia: a selective review. Schizophr Bull 1994; 20:47-62
2. Iacono WG, Moreau M, Beiser M, Fleming JA, Lin TY: Smooth-pursuit eye tracking in first-episode psychotic patients and their relatives. J Abnorm Psychol 1992; 101: 104-116
3. Clementz BA, Grove WM, Iacono WG, Sweeney JA: Smooth-pursuit eye movement dysfunction and liability for schizophrenia: implications for genetic modeling. J Abnorm Psychol 1992; 101:117-129
4. Sweeney J, Clementz B, Escobar M, Li S, Pauler D, Haas G: Mixture analysis of pursuit eye-tracking dysfunction in schizophrenia. Biol Psychiatry 1993; 34:331-341
5. Ross DE, Ochs AL, Pandurangi AK, Thacker LR, Kendler KS: Mixture analysis of smooth pursuit eye movements in schizophrenia. Psychophysiology 1996; 33:390-397
6. Clementz B, Iacono W, Grove W: The construct validity of root-mean-square error for quantifying smooth-pursuit eye tracking abnormalities in schizophrenia. Biol Psychiatry 1996; 39:448-450
7. Rashbass C: The relationship between saccadic and smooth tracking eye movements. J Physiol 1961; 159:326-338
8. Levin S, Luebke A, Zee DS, Hain TC, Robinson DA, Holzman PS: Smooth pursuit eye movements in schizophrenics: quantitative measurements with the search-coil technique. J Psychiatr Res 1988; 22:195-206
9. Clementz B, McDowell J: Smooth pursuit in schizophrenia: abnormalities of open- and closed-loop responses. Psychophysiology 1994; 31:79-86
10. Buchanan R, Carpenter W: Domains of psychopathology: an approach for the reduction of heterogeneity in schizophrenia. J Nerv Ment Dis 1994; 182:193-204
11. Overall JE, Gorham DR: The Brief Psychiatric Rating Scale. Psychol Rep 1962; 10:799-812
12. Blackwood D, Young A, McQueen J, Martin M, Roxborough H, Muir W, Clair DS, Kean D: Magnetic resonance imaging in schizophrenia: altered brain morphology associated with P300 abnormalities and eye tracking dysfunction. Biol Psychiatry 1991; 30:753-769
13. Andreasen NC: Scale for the Assessment of Negative Symptoms (SANS): conceptual and theoretical foundations. Br J Psychiatry Suppl 1989; 7:49-58
14. Katsanis J, Iacono W: Clinical, neuropsychological, and brain structural correlates of smooth-pursuit eye tracking performance in chronic schizophrenia. J Abnorm Psychol 1991; 100: 526-534
15. Sweeney J, Haas G, Clementz B, Escobar M, Drake K, Francis A: Eye tracking dysfunction in schizophrenia: characterization of component eye movement abnormalities, diagnostic specificity and the role of attention. J Abnorm Psychol 1994; 103:222-230
16. Kelly P, Rennie C, Gordon E, Anderson J, Howson A, Meares R: Smooth pursuit eye tracking dysfunction and negative symptoms in schizophrenia. Psychiatry Res 1990; 34:89-97
17. Keefe R, Siever L, Mohs R, Peterson A, Mahon T, Bergman R, Davis K: Eye tracking, schizophrenic symptoms, and schizotypal personality disorder. Eur Arch Psychiatry Neurol Sci 1989; 239: 39-42
18. Lieberman J, Jody D, Alvir J, Ashtari M, Levy D, Bogerts B, Degreef G, Mayerhoff D, Cooper T: Brain morphology, dopamine and eye tracking in first episode schizophrenia: prevalence and clinical correlates. Arch Gen Psychiatry 1993; 50:357-368
19. Siever LJ, Haier RJ, Coursey RD, Sostek AJ, Murphy DL, Holzman PS, Buchsbaum MS: Smooth pursuit eye tracking impairment: relation to other "markers" of schizophrenia and psychologic correlates. Arch Gen Psychiatry 1982; 39:1001-1005
20. Siever LJ, Coursey RD, Alterman IS, Buchsbaum MS, Murphy DL: Impaired smooth-pursuit eye movement: vulnerability marker for schizotypal personality disorder in a normal volunteer population. Am J Psychiatry 1984; 141:1560-1566
21. Siever LJ, Keefe R, Bernstein DP, Coccaro EF, Klar HM, Zemishlany Z, Peterson AE, Davidson M, Mahon T, Horvath T, Mohr R: Eye tracking impairment in clinically identified patients with schizotypal personality disorder. Am J Psychiatry 1990; 147:740-745
22. Kendler K, Ochs A, Gorman A, Hewitt J, Ross D, Mirsky A: The structure of schizotypy: a pilot multitrait twin study. Psychiatry Res 1991; 36:19-36
23. Siever LJ, Friedman L, Moskowitz, J, Mitropoulou V, Keefe R, Roitman S, Merhige D, Trestman R, Silverman J, Mohs R: Eye movement impairment and schizotypal psychopathology. Am J Psychiatry 1994; 151:1209-1215
24. Thaker GK, Cassady S, Adami H, Moran M, Ross DE: Eye movements in spectrum personality disorders: comparison of community subjects and relatives of schizophrenic patients. Am J Psychiatry 1996; 153:362-368
25. Simons R, Katkin W: Smooth pursuit eye movements in subjects reporting physical anhedonia and perceptual aberrations. Psychiatry Res 1985; 14:275-289
26. Carpenter WT Jr, Heinrichs DW, Wagman AMI: Deficit and nondeficit forms of schizophrenia: the concept. Am J Psychiatry 1988; 145:578-583
27. Kirkpatrick B, Buchanan RW, McKenney PD, Alphs LD, Carpenter WT Jr: The Schedule for the Deficit Syndrome: an instrument for research in schizophrenia. Psychiatry Res 1989; 30: 119-123
28. Tamminga CA, Thaker GK, Buchanan R, Kirkpatrick B, Alphs LD, Chase TN, Carpenter WT: Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome. Arch Gen Psychiatry 1992; 49:522-530
29. Buchanan R, Breier A, Kirkpatrick B, Elkashef A, Munson RC, Gellad F, Carpenter WT Jr: Structural abnormalities in deficit and nondeficit schizophrenia. Am J Psychiatry 1993; 150:59-65
30. Thaker G, Kirkpatrick B, Buchanan RW, Ellsberry R, Lahti A, Tamminga C: Oculomotor abnormalities and their clinical correlates in schizophrenia. Psychopharmacol Bull 1989; 25:491-497
31. Spitzer RL, Williams JBW, Gibbon M, First MB: Instruction Manual for the Structured Clinical Interview for DSM-III-R (SCID). New York, New York State Psychiatric Institute, Biometrics Research, 1988
32. Hollingshead AB, Redlich FC: Social Class and Mental Illness: A Community Study. New York, John Wiley & Sons, 1958
33. Gelenberg A, Bassuk E, Schoonover S: The Practitioner's Guide to Psychoactive Drugs. New York, Plenum, 1991
34. Pfohl B, Blum N, Zimmerman M, Stangl D: Structured Interview for DSM-III-R Personality, Revised (SIDP-R). Iowa City, University of Iowa College of Medicine, Department of Psychiatry, 1989
35. Schooler NR, Kane JM: Research diagnoses for tardive dyskinesia (letter). Arch Gen Psychiatry 1982; 39:486-487
36. Dodge R: Five types of eye movement in the horizontal meridian plane of the field of regard. Am J Physiol 1903; 8:307-329
37. Bahill AT, McDonald JD: Frequency limitations and optimal step size for the two-point central difference derivative algorithm with applications to human eye movement data. IEEE Trans Biomed Eng 1983; 3:191-194
38. Bahill A, Clark M, Stark L: The main sequence, a tool for studying human eye movements. Math Biosci 1975; 24:191-204
39. Abel LA, Ziegler AS: Smooth pursuit eye movements in schizophrenies - what constitutes assessment? Biol Psychiatry 1988; 24:746-761
40. Cohen J: Statistical Power Analysis. Hillsdale, NJ, Lawrence Erlbaum Associates, 1988
41. Friedman L, Jesberger JA, Meltzer HY: A model of smooth pursuit performance illustrates the relationship between gain, catch-up saccade rate, and catch-up saccade amplitude in normal controls and patients with schizophrenia. Biol Psychiatry 1991; 30: 537-556
42. Ross DE, Thaker GK, Holcomb HH, Cascella NG, Medoff DR, Tamminga CA: Abnormal smooth pursuit eye movements in schizophrenic patients are associated with cerebral glucose metabolism in oculomotor regions. Psychiatry Res 1995; 58:53-67