Interferon-β interrupts interleukin-6-dependent signaling events in myeloma cells

Blood

Volumn 89, Issue 1, 1997, Pages 261-271

  Berger, Lloyd C ^b   Hawley, Robert G ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; GUANOSINE TRIPHOSPHATE; INTERLEUKIN 6; PHOSPHOTYROSINE; PROTEIN KINASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOREGULATION; MITOGENESIS; MYELOMA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0031036356     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.1.261.261_261_271     Document Type: Article

References (68)

1. Hirano T, Akira S, Taga T, Kishimoto T: Biological and clinical aspects of interleukin 6. Immunol Today 11:443, 1990
2. Hibi M, Murakami M, Saito M, Hirano T, Taga T. Kishimoto T: Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63:1149, 1990
3. Hawley RG: Hematopathology of interleukin-6-type cytokines. Stem Cells 12:155, 1994 (suppl 1)
4. Kishimoto T, Akira S, Narazaki M, Taga T: Interleukin-6 family of cytokines and gp130. Blood 86:1243, 1995
5. Lutticken C, Wegenka UM, Yuan J, Buschmann J, Schindler C, Ziemiecki A, Harpur AG, Wilks AF, Yasukawa K, Taga T, Kishimoto T, Barbieri G, Pellegrini S, Sendtner M, Heinrich PC, Horn F: Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp 130. Science 263:89, 1994
6. Stahl N, Boulton TG, Farruggella T, Ip NY, Davis S, Witthuhn BA, Quelle FW, Silvennoinen O, Barbieri G, Pellegrini S, Ihle JN, Yancopoulos GD: Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 βreceptor components. Science 263:92, 1994
7. Berger LC, Hawley TS, Lust JA, Goldman SJ, Hawley RG: Tyrosine phosphorylation of JAK-TYK kinases in malignant plasma cell lines growth-stimulated by interleukins 6 and 11. Biochem Biophys Res Commun 202:596, 1994
8. Narazaki M, Witthuhn BA, Yoshida K, Silvennoinen O, Yasukawa K, Ihle JN, Kishimoto T, Taga T: Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130. Proc Natl Acad Sci USA 91:2285, 1994
9. Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Silvennoinen O: Signaling through the hematopoietic cytokine receptors. Annu Rev Immunol 13:369, 1995
10. Sadowski HB, Shuai K, Darnell JE Jr, Gilman MZ: A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science 261:1739, 1993
11. Akira S, Nishio Y, Inoue M, Wang X-J, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M, Kishimoto T: Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91 -related transcription factor involved in the gp130-mediated signaling pathway. Cell 77:63, 1994
12. Zhong Z, Wen Z, Darnell JE Jr: Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264:95, 1994
13. Stahl N, Farruggella J, Boulton TG, Zhong Z, Darnell JE Jr, Yancopoulos GD: Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267:1349, 1995
14. Nakafuku M, Satoh T, Kaziro Y: Differentiation factors, including nerve growth factor, fibroblast growth factor, and interleukin-6, induce an accumulation of an active Ras·GTP complex in rat pheochromocytoma PC12 cells. J Biol Chem 267:19448, 1992
15. Egan SE, Weinberg RA: The pathway to signal achievement. Nature 365:781, 1993
16. Yin T, Yang Y-C: Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and on-costatin M in mouse 3T3-L1 cells. J Biol Chem 269:3731, 1994
17. Boulton TG, Stahl N, Yancopoulos GD: Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J Biol Chem 269:11648, 1994
18. Daeipour M, Kumar G, Amaral MC, Nel AE: Recombinant IL-6 activates p42 and p44 mitogen-activated protein kinases in the IL-6 responsive B cell line, AF-10. J Immunol 150:4743, 1993
19. shc, Raf-1, and MEK-1 in the IL-6-induced mitogenactivated protein kinase cascade of a growth-responsive B cell line. J Immunol 153:4436, 1994
20. Sabourin LA, Hawley RG: Suppression of programmed death and G, arrest in B-cell hybridomas by interleukin-6 is not accompanied by altered expression of immediate early response genes. J Cell Physiol 145:564, 1990
21. L. Cancer Res 55:2262, 1995
22. Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe O, Tanaka H, Kuramoto A, Kishimoto T: Autocine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 332:83, 1988
23. Zhang XG, Klein B, Bataille R: Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma. Blood 74:11, 1989
24. Klein B, Zhang X-G, Lu Z-Y, Bataille R: Interleukin-6 in human multiple myeloma. Blood 85:863, 1995
25. Matsuda T, Takahashi-Tezuka M, Fukada T, Okuyama Y, Fujitani Y, Tsukada S, Mano H, Hirai H, Witte ON, Hirano T: Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines. Blood 85:627, 1995
26. Nakajima K, Wall R: Interleukin-6 signals activating junB and TIS11 gene transcription in a B-cell hybridoma. Mol Cell Biol 11:1409, 1991
27. Ravichandran KS, Lorenz U, Shoelson SE, Burakoff SJ: Interaction of She with Grb2 regulates association of Grb2 with mSos. Mol Cell Biol 15:593, 1995
28. Billadeau D, Jelinek DF, Shah N, LeBien TW, Van Ness B: Introduction of an activated N-ras oncogene alters the growth characteristics of the interleukin 6-dependent myeloma cell line ANBL6. Cancer Res 55:3640, 1995
29. Nakajima T, Kinoshita S, Sasagawa T, Sasaki K, Naruto M, Kishimoto T, Akira S: Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci USA 90:2207, 1993
30. Pelech SL, Charest DL, Mordret GP, Siow YL, Palaty C, Campbell D, Charlton L, Samiei M, Sanghera JS: Networking with mitogen-activated protein kinases. Mol Cell Biochem 127:157, 1993
31. Daum G, Eisenmann-Tappe I, Fries H-W, Troppmair J, Rapp UR: The ins and outs of Raf kinases. Trends Biochem Sci 19:474, 1994
32. Aitken A: 14-3-3 proteins on the MAP. Trends Biochem Sci 20:95, 1995
33. Shuai K, Ziemiecki A, Wilks AF, Harpur AG, Sadowski HB, Gilman MZ, Darnell JE Jr: Polypeptide signaling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature 366:580, 1993
34. Ziemiecki A, Harpur AG, Wilks AF: Jak protein tyrosine kinases: Their role in cytokine signalling. Trends Cell Biol 4:207, 1994
35. Darnell JE Jr, Kerr IM, Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415, 1994
36. David M, Petricoin E III, Benjamin C, Pine R, Weber MJ, Larner AC: Requirement for MAP kinase (ERK2) activity in interferon α-and interferon β-stimulated gene expression through STAT proteins. Science 269:1721, 1995
37. Uze G, Lutfalla G, Gresser I: Genetic transfer of a functional human interferon a receptor into mouse cells: Cloning and expression of its cDNA. Cell 60:225, 1990
38. Colamonici OR, Domanski P: Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21. J Biol Chem 268:10895, 1993
39. Novick D, Cohen B, Rubinstein M: The human interferon αl β receptor: Characterization and molecular cloning. Cell 77:391, 1994
40. 2-microglobulin in the human myeloma cell line U-266 and in an α-interferon resistant U-266 subline. Scand J Haematol 37:280, 1986
41. Mandelli F, Avvisati G, Tribalto M: Biology and treatment of multiple myeloma. Curr Opin Oncol 4:73, 1992
42. Schwabe M, Brini AT, Bosco MC, Rubboli F, Egawa M, Zhao J, Princier GL, Kung H: Disruption by interferon-α of an autocrine interleukin-6 growth loop in IL-6-dependent U266 myeloma cells by homologous and heterologous down-regulation of the IL-6 receptor α-and β-chains. J Clin Invest 94:2317, 1994
43. De Maeyer E, De Maeyer-Guignard J: Interferons and Other Regulatory Cytokines. New York, NY, Wiley, 1988
44. Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A, Miyata T, Taniguchi T: Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell 58:729, 1989
45. Williams BRG: Transcriptional regulation of interferon-stimulated genes. Eur J Biochem 200:1, 1991
46. Xu J, Kim S, Chen M, Rockow S, Yi SE, Wagner AJ, Hay N, Weichselbaum RR, Li W: Blockage of the early events of mitogenic signaling by interferon-gamma in macrophages in response to colony-stimulating factor-1. Blood 86:2774, 1995
47. ras upon T-cell activation. Nature 346:719, 1990
48. Rozakis-Adcock M, McGlade J, Mbamalu G, Pelicci G, Daly R, Li W, Batzer A, Thomas S, Brugge J, Pelicci PG, Schlessinger J, Pawson T: Association of the She and Grb2/Sem5 SH2-containing proteins is implicated in the activation of the Ras pathway by tyrosine kinases. Nature 360:689, 1992
49. Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG: A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70:93, 1992
50. Smith DB, Berger LC, Wildeman AG: Modified glutathione S-transferase fusion proteins for simplified analysis of protein-protein interactions. Nucleic Acids Res 21:359, 1993
51. Anthes JC, Zhan Z, Gilchrest H, Egan RW, Siegel MI, Billah MM: Interferon-α down-regulates the interleukin-6 receptor in a human multiple myeloma cell line, U266. Biochem J 309:175, 1995
52. Feng G-S, Hui C-C, Pawson T: SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 259:1607, 1993
53. Vogel W, Lammers R, Huang J, Ullrich A: Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Science 259:1611, 1993
54. Murakami M, Narazaki M, Hibi M, Yawata H, Yasukawa K, Hamaguchi M, Taga T, Kishimoto T: Critical cytoplasmic region of the interleukin 6 signal transducer gp 130 is conserved in the cytokine receptor family. Proc Natl Acad Sci USA 88:11349, 1991
55. Satoh T, Nakamura S, Taga T, Matsuda T, Hirano T, Kishimoto T, Kaziro Y: Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin-6. Mol Cell Biol 8:3346, 1988
56. Schwab G, Siegall CB, Aarden LA, Neckers LM, Nordan RP: Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266. Blood 77:587, 1991
57. Kazlauskas A, Feng G-S, Pawson T, Valius M: The 64-kDa protein that associates with the platelet-derived growth factor receptor β subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp. Proc Natl Acad Sci USA 90:6939, 1993
58. Bennett AM, Tang TL, Sugimoto S, Walsh CT, Neel BG: Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor β to ras. Proc Natl Acad Sci USA 91:7335, 1994
59. Li W, Nishimura R, Kashishian A, Batzer AG, Kim WH, Cooper JA, Schlessinger J: A new function for a phosphotyrosine phosphatase: Linking GRB2-Sos to a receptor tyrosine kinase. Mol Cell Biol 14:509, 1994
60. Liu L, Damen JE, Cutler RL, Krystal G: Multiple cytokines stimulate the binding of a common 145-kilodalton protein to She at the Grb2 recognition site of She. Mol Cell Biol 14:6926, 1994
61. Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G: The 145-kDa protein induced to associate with She by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase. Proc Natl Acad Sci USA 93:1689, 1996
62. Kavanaugh WM, Williams LT: An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. Science 266:1862, 1994
63. Marx J: Two major signal pathways linked. Science 262:988, 1993
64. Guschin D, Rogers N, Briscoe J, Witthuhn B, Watling D, Horn F, Pellegrini S, Yasukawa K, Heinrich P, Stark GR, Ihle JN, Kerr IM: A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6. EMBO J 14:1421, 1995
65. Fuhrer DK, Feng GS, Yang YC: Syp associates with gp130 and Janus kinase 2 in response to interleukin-11 in 3T3-L1 mouse preadipocytes. J Biol Chem 270:24826, 1995
66. Briscoe J, Rogers NC, Witthuhn BA, Watling D, Harpur AG, Wilks AF, Stark GR, Ihle JN, Kerr IM: Kinase-negative mutants of JAK1 can sustain interferon-γ-inducible gene expression but not an antiviral state. EMBO J 15:799, 1996
67. Zhuang H, Patel SV, Tong-Chuan H, Sonsteby SK, Niu Z, Wojchowski DM: Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2. J Biol Chem 269:21411, 1994
68. David M, Chen HE, Goelz S, Larner AC, Neel BG: Differential regulation of the α/β interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol Cell Biol 15:7050, 1995