Combinatorial library cloning of human antibodies to Streptococcus pneumoniae capsular polysaccharides: Variable region primary structures and evidence for somatic mutation of Fab fragments specific for capsular serotypes 6B, 14, and 23F

Infection and Immunity

Volumn 69, Issue 2, 2001, Pages 853-864

  Lucas, A H ^a   Moulton, K D ^a   Tang, V R ^a   Reason, D C ^a  

^a CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; PNEUMOCOCCUS VACCINE; POLYSACCHARIDE;

ADULT; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; BACTERIAL GENE; BACTERIAL IMMUNITY; BACTERIAL MEMBRANE; DNA POLYMORPHISM; FEMALE; GENE LIBRARY; GENE STRUCTURE; HUMAN; HUMAN EXPERIMENT; MALE; MOLECULAR CLONING; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEROTYPE; SOMATIC MUTATION; STREPTOCOCCUS PNEUMONIAE; VACCINATION;

ADULT; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL CAPSULES; BASE SEQUENCE; CLONING, MOLECULAR; COMBINATORIAL CHEMISTRY TECHNIQUES; FEMALE; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; PNEUMOCOCCAL VACCINES; STREPTOCOCCUS PNEUMONIAE;

EID: 0035145467     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.2.853-864.2001     Document Type: Article

References (71)

1. Human antibodies elicited by a pneumococcal vaccine express idiotypic determinants indicative of VH3 gene segment usage
2. H3b gene subfamily is highly polymorphic
3. Restricted Ig H chain V gene usage in the human response to Haemophilus influenzae type b capsular polysaccharide
4. Streptococcus pneumoniae: Virulence factors, pathogenesis, and vaccines
5. Avidty of IgG for Streptococcus pneumoniae type 6B and 23F polysaccharides in infants primed with pneumococcal conjugates and boosted with polysaccharide or conjugate vaccines
6. Differences in the avidity of antibodies evoked by four different pneumococcal conjugate vaccines in early childhood
7. Pneumococcal infections
8. T cell regulation of the antibody response to bacterial polysaccharide antigens: An examination of some general characteristics and their implications
9. Assembly of combinatorial libraries on phage surfaces: The gene III site
10. The human immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments
11. The progeny of a single virgin B cell predominates the human recall B cell response to the capsular polysaccharide of Haemophilus influenzae type b
12. Immunogenetic analysis of the immune response to pneumococcal polysaccharide
13. Efficacy of heptavalent conjugate pneumococcal vaccine (Wyeth Lederle) in 7000 infants and children: Results of the Northern California Kaiser Permanente efficacy trial
14. Avidity maturation, repertoire shift, and strain differences in antibodies to bacterial levan, a type 2 thymus-independent polysaccharide antigen
15. Pneumococcal conjugate vaccine primes for polysaccharide-inducible IgG2 antibody responses in children with recurrent otitis media acuta
16. Analysis of heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction
17. Mechanisms of host defense against infection with Streptococcus pneumoniae
18. Pneumococcal polysaccharide vaccine efficacy: An evaluation of current recommendations
19. A pneumococcal capsular polysaccharide vaccine induces a repertoire shift with increased VH3 expression in peripheral blood B cells from human immunodeficiency virus (HIV)-uninfected but not HIV-infected persons
20. H segments
21. The protection: The unit of humoral immunity selected by evolution
22. Safety and immunogenicity of tetravalent pneumococcal vaccines containing 6B, 14, 19F and 23F polysaccharides coupled to either tetanus toxoid or diphtheria toxoid in young infants and their boosterability by native polysaccharide antigens
23. Somatic insertions and deletions shape the human antibody repertoire
24. Variable region expression in the antibody responses of infants vaccinated with Haemophilus influenzae type b polysaccharide-protein conjugates: Description of a new λ light chain-associated idiotype and the relation between idiotype expression, avidity, and vaccine formulation
25. The first dose of a Haemophilus influenzae type b conjugate vaccine reactivates memory B cells: Evidence for extensive clonal selection, intraclonal affinity maturation and multiple isotype switches to IgA2
26. New vaccines for the prevention of pneumococcal infections
27. Immunoglobulin VH clan and family predicts variable domain structure and may influence antigen binding
28. Conjugate vaccines against Streptococcus pneumoniae
29. Differences within mono- and dizygotic twin-pairs in spectrotypes and clones of IgG2 antibodies to pneumococcal polysaccharide typed and C-polysaccharide after vaccination
30. The human immunoglobulin kappa locus. Characterization of the duplicated A regions
31. Genetic basis and somatic evolution of a human polysaccharide-specific antibody repertoire
32. Oligoclonality of serum immunoglobulin G antibody responses to Streptococcus pneumoniae capsular polysaccharide serotypes 6B, 14, and 23F
33. An idiotypic marker associated with a germ-line encoded κ light chain variable region that predominates the vaccine-induced human antibody response to Haemophilus influenzae b polysaccharide
34. Role of κII-A2 L chain CDR-3 junctional residues in human antibody binding to the Haemophilus influenzae type b polysaccharide
35. Polysaccharide vaccines as probes of antibody repertoires in man
36. Systemic immunization with pneumococcal vaccine induces a predominant IgA2 response of peripheral blood lymphocytes and increases of both serum and secretory anti-pneumococcal antibodies
37. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus
38. Protective and nonprotective monoclonal antibodies to Cryptococcus neoforroans originating from one B cell
39. Identification of cross-reactive antibodies with low opsonophagocytic activity for Streptococcus pneumoniae
40. Immunologic priming of young children by pneumococcal glycoprotein conjugate, but not polysaccharide vaccines
41. Insertions and deletions in hypervariable loops of antibody heavy chains contribute to molecular diversity
42. The human immunoglobulin lambda variable (IGLV) genes and joining (IGLJ) segments
43. The human immunoglobnlin heavy variable genes
44. The repertoire of human antibodies to the carbohydrate capsule of Streptococcus pneumoniae 6B
45. Human immunoglobnlin heavy-chain variable region genes: Organization, polymorphism, and expression
46. Predominant V-region gene configurations in the human antibody response to Haemophilus influenzae capsule polysaccharide
47. Analysis of human monoclonal antibodies elicited by vaccination with a Cryptococcus neoformans glucuronooxylomannan capsular polysaccharide vaccine
48. Human Feb fragments specific for the Haemophilus influenzae b polysaccharide isolated from a bacteriophage combinatorial library use variable region gene combinations and express idiotype that mirror in vivo expression
49. Considerations for formulating the second-generation pneumococcal capsular polysaccharide vaccine with emphasis on the cross-reactive types within groups
50. Reduction in functional antibody activity against Streptococcus pneumoniae in vaccinated elderly individuals highly correlates with decreased IgG antibody avidity
51. Prevalence and polymorphism of human VH3 genes
52. The human immunoglobulin kappa locus: Polymorphism and haplotypes of Caucasoid and non-Caucasoid individuals
53. Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. III. A single VκII gene and one of several J genes are joined by an invariant arginine to form the most common L chain V region
54. L families
55. Structure-function studies of human monoclonal antibodies to pneumococcus type 3 polysaccharide
56. Pneumococcal disease: Prospects for a new generation of vaccines
57. Variable region diversity in circulating human antibodies specific for the capsular polysaccharide of Haemophilus influenzae type b
58. H family-restricted staphylococcal B cell superantigen
59. High-frequency representation of a single VH gene in the expressed human B cell repertoire
60. Repertoire of human antibodies against the polysaccharide capsule of Streptococcus pneumoniae serotype 6B
61. Role oft cells and germinal center formation in the generation of immune responses to the thymus-independent carbohydrate dextran B512
62. κ domain
63. H segments with different hypervariable loops
64. Avidity as a determinant of the protective efficacy of human antibodies to pneumococcal capsular polysaccharides
65. Reaction of germinal centers in the T-cell-independent response to the bacterial polysaccharide α(1-6)dextran
66. Human anti-gal heavy, chains: Preferential use of VHIII and the presence of somatic mutations
67. Structure and specificity of anti-ganglioside autoantibodies associated with motor nenropathies
68. Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes
69. Molecular and functional characteristics of a protective human monoclonal antibody to serotype 8 Streptococcus pneumoniae capsular polysaccharide