Evidence for an elevation in serum interleukin-2 and tumor necrosis factor-α levels before the clinical manifestations of preeclampsia

American Journal of Reproductive Immunology

Volumn 38, Issue 2, 1997, Pages 89-93

  Hamai, Yoko ^a   Fujii, Tomoyuki ^a   Yamashita, Takahiro ^a   Nishina, Hidenori ^a   Kozuma, Shiro ^a   Mikami, Yasuyo ^b   Taketani, Yuji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO HOSPITAL   (Japan)

Author keywords

Early pregnancy; Immune regulation; Interleukin 2; Preeclampsia; Tumor necrosis factor

Indexed keywords

INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FETOPLACENTAL UNIT; FIRST TRIMESTER PREGNANCY; HUMAN; IMMUNOREGULATION; PREECLAMPSIA; PRIORITY JOURNAL;

EID: 0030798819     PISSN: 87558920     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0897.1997.tb00281.x     Document Type: Article

References (16)

1. Toder V, Blank M, Gleicher N, Voljovich I, Mashiah S, Nebel L: Activity of natural killer cells in normal pregnancy and edema-protein-hypertension gestosis. Am J Obstet Gynecol 1983;145:7-10.
2. Hara N, Fujii T, Okai T, Taketani Y: Histochemical demon- stration of interleukin-2 in decidua cells of patients with preeclampsia. Am J Reprod Immunol 1995; 34:44-51.
3. Sunder-Plassmann G, Derfler K, Wagner L, Stockenhuber F, Endler M, Nowotny C, Balcke P: Increased serum activity of interleukin-2 in patients with pre-eclampsia. J Autoimmun 1989;2:203-205.
4. Vince GS, Starkey PM, Austgulen R, Kwiatkowski D, Redman CW: Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with preeclampsia. Br J Obstet Gynaecol 1995; 102;20-25.
5. Kupfermine MJ, Peaceman AM, Wigton TR, Rehnberg KA, Socol ML: Tumor necrosis factor-alpha is elevated in plasma and amniotic fluid of patients with severe preeclampsia. Am J Obstet Gynecol 1994;170:1752-1759.
6. Wegmann TG, Athanassakis I, Guilbert L, Branch D, Dy M, Menu E, Chaouat G: The role of M-CSF and GM-CSF in fostering placental growth, fetal growth, and fetal survival. Transplant Proc 1989;21:566-568.
7. Robb RJ: Interleukin-2: the molecule and its function. Immunol Today 1984;5:203-209.
8. Starkey PM: Expression on cells of early human pregnancy decidua, of the p75, IL-2 and p145, IL-4 receptor proteins. Immunology 1991;73:64-70.
9. Ferry BL, Starkey PM, Sargent IL, Watt GM, Jackson M, Redman CW: Cell populations in the human early pregnancy decidua: Natural killer activity and response to interleukin- 2 of CD56-positive large granular lymphocytes. Immunology 1990;70:446-452.
10. Stark JM: Pre-eclampsia and cytokine induced oxidative stress. Br J Obstet Gynaecol 1993;100:105-109.
11. Arai K, Lee F, Miyajima A, Miyatake S, Arai N, Yokota T: Cytokines: Coordinators of immune and inflammatory responses. Annu Rev Biochem 1990;59:783-836.
12. Le J, Vilcek J: Biology of disease. Tumor necrosis factor and interleukin-1: Cytokines with multiple overlapping biological activities. Lab Invest 1987;56:234-248.
13. Beutler B, Cerami A: The biology of cachectin/TNF - α primary mediator of the host response. Annu Rev Immunol 1989;7:625-655.
14. Beutler B, Cerami A: Cachectin: More than a tumor necrosis factor. N Engl J Med 1987;316:379-385.
15. Khong TY, De Wolf F, Robertson WB, Brosens I: Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small- for-gestational age infants. Br J Obstet Gynaecol 1986;93:1049-1059.
16. De Groot CJ, O'Brien TJ, Taylor RN: Biochemical evidence of impaired trophoblastic invasion of decidual stroma in women destined to have preeclampsia. Am J Obstet Gynecol 1996; 175:24-29.