Sodium pentobarbital reduces transmural dispersion of repolarization and prevents torsades de pointes in models of acquired and congenital long QT syndrome

Journal of Cardiovascular Electrophysiology

Volumn 10, Issue 2, 1999, Pages 154-164

  Shimizu, Wataru ^a   McMahon, Brandon ^a   Antzelevitch, Charles ^a  

^a MASONIC MEDICAL RESEARCH LABORATORY   (United States)

Author keywords

Arrhythmias; ATX II; HERG; Heterogeneity; LQTS; M cell; SCN5A; Sotalol

Indexed keywords

ATX 2; NEUROTOXIN; PENTOBARBITAL; SOTALOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; HEART LEFT VENTRICLE; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; LONG QT SYNDROME; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; TORSADE DES POINTES;

EID: 0032967122     PISSN: 10453873     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1540-8167.1999.tb00656.x     Document Type: Article

References (37)

1. Moran JM, Kehoe RF, Leob JM, et al: Extended endocardial resection for the treatment of ventricular tachycardia and ventricular fibrillation. Ann Thorac Surg 1982;34:538-550.
2. Brodman R, Fisher JD, Johnston DR, et al: Results of electrophysiologically guided operations for drug-resistant recurrent ventricular tachycardia and ventricular fibrillation due to coronary artery disease. J Thorac Cardiovasc Surg 1984;87:431-438.
3. Kron IL, Lerman BB, DiMarco JP: Extended subendocardial resection: A surgical approach to ventricular tachyarrhythmias that cannot be mapped intraoperatively. J Thorac Cardiovasc Surg 1985;90:586-591.
4. Dawson AK, Leon AS, Taylor HL: Effect of pentobarbital anesthesia on vulnerability to ventricular fibrillation. Am J Physiol 1980;239:H427-H431.
5. Hunt GB, Ross BL: Comparison of effects of three anesthetic agents on induction of ventricular tachycardia in a canine model of myocardial infarction. Circulation 1988;78:221-226.
6. Duker GD, Linhardt GS, Rahmberg M: An animal model for studying class III-induced proarrhythmias in the halothane-anesthetized dog. (Abstract) J Am Coll Cardiol 1994;23:326A.
7. Weissenburger J, Nesterenko VV, Antzelevitch C: M cells contribute to transmural dispersion of repolarization and to the development of Torsade de Pointes in the canine heart in vivo. (Abstract) PACE 1996;19(Pt II):II-707.
8. Anyukhovsky EP, Sosunov EA, Rosen MR: Regional differences in electrophysiologic properties of epicardium, midmyocardium and endocardium: In vitro and in vivo correlations. Circulation 1996;94:1981-1988.
9. El-Sherif N, Caref EB, Yin H, et al: The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome: Tridimensional mapping of activation and recovery patterns. Circ Res 1996;79:474-492.
10. El-Sherif N, Chinushi M, Caref EB, et al: Electrophysiological mechanism of the characteristic electrocardiographic morphology of torsade de pointes tachyarrhythmias in the long-QT syndrome: Detailed analysis of ventricular tridimensional activation patterns. Circulation 1997;96:4392-4399.
11. Yan GX, Antzelevitch C: Cellular basis for the electrocardiographic J wave. Circulation 1996;93:372-379.
12. Antzelevitch C, Sun ZQ, Zhang ZQ, et al: Cellular and ionic mechanisms underlying erythromycin-induced long QT and torsade de pointes. J Am Coll Cardiol 1996;28:1836-1848.
13. Shimizu W, Antzelevitch C: Sodium channel block with mexiletine is-effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long-QT syndrome. Circulation 1997;96:2038-2047.
14. Shimizu W, Antzelevitch C: Cellular basis for the electrocardiographic features of the LQT1 form of the long QT syndrome: Effects of β-adrenergic agonists, antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes. Circulation 1998;98:2314-2322.
15. Shimizu W, Antzelevitch C: Characteristics of spontaneous as well as stimulation-induced torsade de pointes in LQT2 and LQT3 models of the long QT syndrome. (Abstract) Circulation 1997;96:I-554.
16. Yan GX, Shimizu W, Antzelevitch C: Characteristics and distribution of M cells in arterially-perfused canine left ventricular wedge preparations. Circulation 1998;98:1921-1927.
17. Yan GX, Antzelevitch C: Cellular basis for the normal T wave and the electrocardiographic manifestations of the long QT syndrome. Circulation 1998;98:1928-1936.
18. Shimizu W, Antzelevitch C: Cellular and ionic basis for T wave alternans under long QT conditions. Circulation 1999;(In press).
19. + channel blockade, °-adrenergic simulation, and rapid pacing in a cellular model mimicking the SCN5A and HERG defects present in the long-QT syndrome. Circ Res 1996;78:1009-1015.
20. Chinushi M, Restivo M, Caref EB, et al: The electrophysiological basis of arrhythmogenicity of QT/T alternans in the long QT syndrome: Tridimensional analysis of the kinetics of cardiac repolarization. Circ Res 1998;83:614-628.
21. Priano LL, Traber DL, Wilson RD: Barbiturate anaesthesia: An abnormal physiologic situation. J Pharmacol Ther 1969;165:126-135.
22. Lindmar R, Loffelholz K, Weide W: Inhibition by pentobarbital of the acetylcholine release from the postganglionic parasympathetic neuron of the heart. J Pharmacol Ther 1979;210:166-173.
23. Urthaler F, Krames BL, James TN: Selective effects of pentobarbital on automaticity and conduction in the intact canine heart. Cardiovasc Res 1974;8:46-57.
24. Nattel S, Wang ZG, Matthews C: Direct electrophysiological actions of pentobarbital at concentrations achieved during general anesthesia. Am J Physiol 1990;259:H1743-H1751.
25. Luo CH, Rudy Y: A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circ Res 1995;74:1097-1113.
26. Antzelevitch C, Sicouri S, Litovsky SH, et al: Heterogeneity within the ventricular wall: Electrophysiology and pharmacology of epicardial, endocardial and M cells. Circ Res 1991;69:1427-1449.
27. Antzelevitch C, Sicouri S: Clinical relevance of cardiac arrhythmias generated by afterdepolarizations: The role of M cells in the generation of U waves, triggered activity and torsade de pointes. J Am Coll Cardiol 1994;23:259-277.
28. Antzelevitch C, Sicouri S, Lukas A, et al: Regional differences in the electrophysiology of ventricular cells: Physiological and clinical implications. In Zipes DP, Jalife J, eds: Cardiac Electrophysiology: From Cell to Bedside. W.B. Saunders Co., Philadelphia, 1995, pp. 228-245.
29. Sicouri S, Antzelevitch C: A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle: The M cell. Circ Res 1991;68:1729-1741.
30. Sicouri S, Quist M, Antzelevitch C: Evidence for the presence of M cells in the guinea pig ventricle. J Cardiovasc Electrophysiol 1996;7:503-511.
31. Drouin E, Charpentier F, Gauthier C, et al: Electrophysiological characteristics of cells spanning the left ventricular wall of human heart: Evidence for the presence of M cells. J Am Coll Cardiol 1995;26:185-192.
32. Sicouri S, Antzelevitch C: Electrophysiologic characteristics of M cells in the canine left ventricular free wall. J Cardiovasc Electrophysiol 1995;6:591-603.
33. Ks contributes to the longer action potential of the M cell. Circ Res 1995;76:351-365.
34. Eddlestone GT, Zygmunt AC, Antzelevitch C: Larger late sodium current contributes to the longer action potential of the M cell in canine ventricular myocardium. (Abstract) PACE 1996:19(Pt II):II-569.
35. Gilat E, Rubinstein I, Binah O: Effect of sodium pentobarbital on the transmembrane action potential and the slow inward current of guinea pig ventricular myocytes. J Cardiovasc Pharmacol 1987;10:485-488.
36. Sun ZQ, Eddlestone GT, Antzelevitch C: Ionic mechanisms underlying the effects of sodium pentobarbital to diminish transmural dispersion of repolarization. (Abstract) PACE 1997;20:II-1116.
37. Sicouri S, More S, Litovsky SH, et al: Chronic amiodarone reduces transmural dispersion of repolarization in the canine heart. J Cardiovasc Electrophysiol 1997;8:1269-1279.