Oxidative stress-induced metabolic alterations in rat brain astrocytes studied by multinuclear NMR spectroscopy

Journal of Neuroscience Research

Volumn 58, Issue 4, 1999, Pages 576-585

  Brand, Annette ^b   Leibfritz, Dieter ^b   Richter Landsberg, Christiane ^a  

^a UNIVERSITY OF OLDENBURG   (Germany)

^b UNIVERSITY OF BREMEN   (Germany)

Author keywords

Cytotoxicity; Energy metabolism; Glial cells; Hydrogen peroxide; NMR spectroscopy

Indexed keywords

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN METABOLISM; CELL CULTURE; CELL METABOLISM; CELL STRUCTURE; GLYCOLYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OSMOREGULATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BRAIN; BRAIN CHEMISTRY; CELL SURVIVAL; CELLS, CULTURED; COLORING AGENTS; ENERGY METABOLISM; GLUCOSE; GLUTAMINE; GLYCOLYSIS; HYDROGEN PEROXIDE; MAGNETIC RESONANCE SPECTROSCOPY; OSMOTIC PRESSURE; OXIDANTS; OXIDATIVE STRESS; RATS;

EID: 0033571766     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19991115)58:4<576::AID-JNR10>3.0.CO;2-D     Document Type: Article

References (41)

1. Ankarcrona M, Dypbuki JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P. 1995. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15:961-973.
2. Aoshima M, Satoh T, Sakai N, Yamada M, Enokido Y, Ikeuchi T, Hatanaka H. 1997. Generation of free radicals during lipid hydroperoxide-triggered apoptosis in PC12h cells. Biophys Biochem Acta 1345:35-42.
3. Atabay C, Cagnoli CM, Kharlamov E, Ikonomovic MD, Manev H. 1996. Removal of serum from primary cultures of cerebellar granule neurons induces oxidative stress and DNA fragmentation: protection with antioxidants and glutamate receptor antagonists. J Neurosci Res 43:465-475.
4. Atlante A, Gagliardi S, Minervini GM, Ciotti MT, Marra E, Calissano P. 1997. Glutamate neurotoxicity in rat cerebellar granule cells: a major role for xanthine oxidase in oxygen radical formation. J Neurochem 68:2038-2045.
5. Ben-Yoseph O, Boxer PA, Ross BD. 1996. Assessment of the role of the glutathione and pentose phosphate pathways in the protection of primary cerebrocortical culture from oxidative stress. J Neurochem 66:2329-2337.
6. Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA. 1995. Apoptosis and necrosis: two distinct events induced respectively by mild and intense insults with NMDA or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 92:7162-7166.
7. Borenfreund E, Puerner JA. 1986. Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol Lett 24:19-124
8. Brand A, Richter-Landsberg C, Leibfritz D. 1993 Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci 15:289-298.
9. Brand A, Richter-Landsberg C, Leibfritz D. 1997. Metabolism of acetate in rat brain neurons, astrocytes, and cocultures: metabolic interactions between neurons and glia cells, monitored by NMR spectroscopy. Cell Mol Biol 43:645-657.
10. Brand A, Leibfritz D, Hamprecht B, Dringen R. 1998. Metabolism of cysteine in astroglial cells: synthesis of hypotaurine and taurine. J Neurochem 71:827-832.
11. +-ATPase activity of the brain microsomal membranes. Cell Biol Int Rep 16: 927-936.
12. Flögel U, Niendorf T, Serkova N, Brand A, Leibfritz D. 1995. Changes in organic solutes, volume, energy state and metabolism associated with osmotic stress in a glial cell line: A multinuclear NMR study. Neurochem Res 20:793-802.
13. Gaitonde MK, Evison E, Evans GM. 1983. The rate of utilization of glucose via hexose-monophosphate shunt in brain. J Neurochem 41:1253-1269.
14. Goa J. 1953. A micro Biuret method for protein determination. Scand J Clin Lab Invest 5: 218-222.
15. Halliwell B. 1992. Reactive oxygen species and the central nervous system. J Neurochem 59: 1609-1623.
16. Huxtable RJ. 1989. Taurine in the central nervous system and the mammalian actions of taurine. Progr Neurobiol 32:471-533.
17. Huxtable RJ. 1992. Physiological action of taurine. Physiol Rev 72:101-163.
18. Isaacks RE, Bender AS, Kim CY, Prieto NM, Norenberg, MD. 1994. Osmotic regulation of myo-inositol uptake in primary astrocyte cultures. Neurochem Res 19:331-338.
19. Jesberger JA, Richardson JS. 1991. Oxygen free radicals and brain dysfunction. Intern J Neurosci 57:1-17.
20. Kimelberg HK. 1991. Swelling and volume control in brain astroglial cells. In: Gilles R, Hoffman EK, Bolis L, editors. Advances in comparative and environmental physiology 9: volume and osmolality control in animal cells. Berlin, Heidelberg, Germany: Springer-Verlag, p. 81-117.
21. Kimelberg HK, Ransom BR. 1986. Physiological and pathological aspects of astrocytic swelling. In: Federoff S, Vernadakis A, editors. Astrocytes, vol 3. Orlando: Academic Press. p. 129-166.
22. Kimelberg HK, Goderie SK, Higman S, Pang S, Waniewski RA. 1990. Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures. J Neurosci 10:1583-1591.
23. Leist M, Nicotera P. 1998. Apoptosis, excitoxicity, and neuropathology. Exp Cell Res 239: 183-201.
24. Lindsay R. 1986. Reactive gliosis. In: Fedoroff S, Vernadakis A, editors. Astrocytes: cell biology and pathology of astrocytes, vol 3. New York: Academic Press, p. 231-262.
25. McCarthy KD, DeVellis J. 1980. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 85:890-902.
26. 2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons. J Neurochem 65:1740-1751.
27. Mischel RE, Kim YS, Sheldon RA, Ferriero DM. 1997. Hydrogen peroxide is selectively toxic to immature murine neurons in vitro. Neurosci Lett 231:17-20.
28. Oliver CN, Starke-Reed PE, Stadtman ER, Liu GJ, Carney JM, Floyd RA. 1990. Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain. Proc Natl Acad Sci USA 87:5144-5147.
29. Pasantes-Morales H, Schousboe A. 1988. Volume regulation in astrocytes: a role for taurine as osmoeffector. J Neurosci Res 20:505-509.
30. Perry TL, Hansen S. 1973. Quantification of free amino compounds of rat brain: identification of hypotaurine. J Neurochem 21:1009-1011.
31. Ratan RR, Murphy TM, Baraban MJ. 1994. Oxidative stress induces apoptosis in embryonic cortical neurons. J Neurochem 62:376-379.
32. Reier PJ. 1986. Gliosis following CNS injury: the anatomy of astrocytic scars and their influences on axonal elongation. In: Fedoroff S, Vernadakis A, editors. Astrocytes. Cell biology and pathology of astrocytes, vol 3. New York: Academic Press. p. 263-324.
33. Richter-Landsberg C, Besser A. 1994. Effects of organotins on rat brain astrocytes inculture. J Neurochem 63:2202-2209.
34. Richter-Landsberg C, Vollgraf U. 1998. Mode of cell injury and death after hydrogen peroxide exposure in cultured oligodendroglia cells. Exp Cell Res 244:218-229.
35. Saransaari P, Oja SS. 1997. Enhanced taurine release in cell-damaging conditions in the developing and aging mouse hippocampus. Neuroscience 79:847-854.
36. Satoh T, Enokido Y, Aoshima H, Uchimara Y, Hatanaka H. 1997. Changes in mitochondrial membrane potential during oxidative stress-induced apoptosis. J Neurosci Res 50:413-420.
37. Schor NF. 1988. Inactivation of mammalian brain glutamine synthetase by oxygen radicals. Brain Res 456:17-21.
38. Shaka AJ, Keeler J, Frenkiel T, Freeman R. 1983. An improved sequence for broadband decoupling: WALTZ-16. J Magn Reson 52:335-338.
39. 2+ exchanger. Glia 12:36-342.
40. Vitarella D, DiRisio DJ, Kimelberg HJ, Ascher M. 1994. Potassium and taurine release are highly correlated with regulatory volume decrease in neonatal primary rat astrocyte cultures. J Neurochem 63:1143-1149.
41. Whittemore ER, Loo DT, Cotman C. 1994. Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons. NeuroReport 5:1485-1488.