T cell receptor Vβ chain restriction and preferred CDR3 motifs of liver-kidney microsomal antigen (LKM-1)-reactive T cells from autoimmune hepatitis patients

Liver

Volumn 21, Issue 1, 2001, Pages 18-25

  Arenz, Monika ^a   Pingel, Sabine ^a   Schirmacher, Peter ^a,b   Meyer Zum Büschenfelde, Karl Hermann ^a   Löhr, Hanns F ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Autoimmune hepatitis; Autoreactive T cells; CDR3 regions; Liver kidney microsomal antigen; T cell receptor

Indexed keywords

CD4 ANTIGEN; LIVER KIDNEY MICROSOMAL ANTIGEN; NUCLEOTIDE; PEPTIDE; RECOMBINANT ANTIGEN; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ANALYSIS; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNE HEPATITIS; CELL CLONE; CELL ISOLATION; CELL SPECIFICITY; CELLULAR IMMUNITY; CLINICAL ARTICLE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DILUTION; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOLOGY; IMMUNOREACTIVITY; LIVER BIOPSY; LYMPHOCYTE ACTIVATION; MALE; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; ADULT; AGED; AUTOANTIBODIES; CLONE CELLS; DNA; FEMALE; HEPATITIS, AUTOIMMUNE; HEPATITIS, CHRONIC; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

EID: 0035139883     PISSN: 01069543     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0676.2001.210103.x     Document Type: Article

References (25)

1. Autoimmunity and liver disease
2. Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of different etiology
3. Histologic features in autoimmune hepatitis
4. Susceptibility to autoimmune chronic active hepatitis: Human leukocyte antigens DR4 and A1-B8-DR3 are independent risk factors
5. T-cell antigen receptor genes and T-cell recognition
6. Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1
7. Clonal analysis of liver-infiltrating T cells in patients with LKM-1 antibody-positive autoimmune chronic active hepatitis
8. Overlapping but distinct specificities of anti-liver-kidney microsome antibodies in autoimmune hepatitis type II and hepatitis C revealed by recombinant native CYP2D6 and novel peptide epitopes
9. Autoreactive CD4+ LKM-specific and anticlonotypic T-cell responses in LKM-1 antibody-positive autoimmune hepatitis
10. Limited T cell receptor Vβ-chain repertoire of liver-infiltrating T cells in autoimmune hepatitis
11. Limited usage of T-cell receptor β-chains and sequences of the complementarity determining region 3 of lymphocytes infiltrating in the liver of autoimmune hepatitis
12. International autoimmune hepatitis group report: Review of criteria for diagnosis of autoimmune hepatitis
13. Absence of anti-LKM-1 antibody in hepatitis C viral infection in the United States of America
14. Antigen-independent in vitro T cell expansion does not affect the T cell receptor Vβ repertoire
15. LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase
16. The human asialoglycoprotein receptor (hASGPR) is a target antigen for liver-infiltrating T cells in autoimmune chronic active hepatitis and primary biliary cirrhosis
17. A beta-galactosidase linked immunoassay for the analysis of antigens on individual cells
18. Interaction of Staphylococcus aureus toxin "superantigens" With human T cells
19. An experimentally validated panel of subfamily-specific oligonucleotide primers (V alpha 1-w29/V beta 1-w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction
20. Selection for T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis
21. Common intra-articular T cell expansions in patients with reactive arthritis: Identical β-chain junctional sequences and cytotoxicity toward HLA-B27
22. Analysis of T cell receptor Vβ repertoire in liver-infiltrating lymphocytes in chronic hepatitis C
23. Clonotypic analysis of T cells in patients with autoimmune and viral hepatitis
24. T cell repertoire in the liver of patients with autoimmune hepatitis
25. Evolution of antigen-specific T cell receptors in vivo: Preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs