Trypanosome RNA editing: Simple guide RNA features enhance U deletion 100-fold

Molecular and Cellular Biology

Volumn 21, Issue 3, 2001, Pages 884-892

  Cruz Reyes, J ^a   Zhelonkina, A ^a   Rusche, L ^a   Sollner Webb, B ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTOZOAL PROTEIN; RNA;

ARTICLE; BASE PAIRING; GENE DELETION; GENE INSERTION; GENE SEQUENCE; NONHUMAN; PRIORITY JOURNAL; RNA EDITING; RNA STRUCTURE; TRYPANOSOMA;

ANIMALS; BASE PAIRING; BASE SEQUENCE; DNA PRIMERS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RNA EDITING; RNA STABILITY; RNA, GUIDE; RNA, MESSENGER; RNA, PROTOZOAN; SEQUENCE DELETION; TRYPANOSOMA BRUCEI BRUCEI;

PROTOZOA; TRYPANOSOMA;

EID: 0035136534     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.3.884-892.2001     Document Type: Article

References (36)

1. The mechanism of U insertion/deletion RNA editing in kinetoplastid mitochondria
2. Association of guide RNA binding protein gBP21 with active RNA editing complexes in Trypanosoma brucei
3. Mechanism and evolution of RNA editing in kinetoplastida
4. A model for RNA editing in kinetoplastid mitochondria: "guide" RNA molecules transcribed from maxicircle DNA provide the edited information
5. Guide RNAs in kinetoplastid mitochondria have a nonencoded 3′ oligo(U) tail involved in recognition of the preedited region
6. Chimeric gRNA-mRNA molecules with oligo(U) tails covalently linked at sites of RNA editing suggest that U addition occurs by transesterification
7. Kinetoplast RNA editing does not require the terminal 3′ OH of the gRNA terminus but can inhibit in vitro U insertion
8. Guide RNA-directed uridine-insertion RNA editing in vitro
9. RNA editing: World's smallest introns
10. Trypanosome U-deletional RNA editing involves gRNA-directed endonuclease cleavage, terminal U-exonuclease and RNA ligase activities
11. Trypanosoma brucei RNA editing: Adenosine nucleotides inversely affect U deletion and U insertion reactions at mRNA cleavage
12. Trypanosoma brucei U insertion and U deletion activities co-purify with an enzymatic editing complex but are differentially optimized
13. Unexpected electrophoretic migration of RNA with different 3′ termini causes a RNA sizing ambiguity that can be resolved using nuclease P1-generated sequencing ladders
14. Defining the editing "reaction."
15. A threedimensional working model for a guide RNA from Trypanosoma brucei
16. Uridylate addition and RNA ligation contribute to the specificity of kinetoplastid insertion RNA editing
17. RNA editing: A mechanism for gRNA-specified uridylate insertion into precursor mRNA
18. RNA editing: Getting U into RNA
19. In vitro uridine insertion RNA editing mediated by cis-acting guide RNAs
20. Trypanosoma brucei gBP21
21. Different Trypanosoma brucei guide RNA molecules associate with an identical complement of mitochondrial proteins in vitro
22. The involvement of gRNA-binding protein gBP21 in RNA editing - An in vitro and in vivo analysis
23. Identification by UV crosslinking of oligo(U)-binding proteins in mitochondria of the insect trypanosomatid Crithidia fasciculata
24. Kinetoplast RNA editing associated protein 1 (REAP-1): A novel editing complex protein with repetitive domains
25. Trypanosoma brucei guide RNA poly(U) tail formation is stabilized by cognate mRNA
26. Site-specific modification of pre-mRNA: The 2′ hydroxyl group at the splice site
27. RNA binding properties of the mitochondrial Y-box protein RBP16
28. Resolution of the RNA editing gRNA-directed endonuclease from two other endonucleases of Trypanosoma brucei mitochondria
29. Purification of a functional enzymatic editing complex from Trypanosoma brucei mitochondria
30. The secondary structure of guide RNA molecules from Trypanosoma brucei
31. RNA editing: Transfer of genetic information from gRNA to precursor mRNA in vitro
32. Direct visualization of uridylate deletion in vitro suggests a mechanism for kinetoplastid RNA editing
33. A guide to RNA editing
34. Trypanosoma RNA editing: Resolved
35. RNA editing in kinetoplastid protozoa
36. Trypanosoma brucei TBRGG1, a mitochondrial oligo(U)-binding protein that co-localizes with an in vitro RNA editing activity