A comparison of the effect of inducers on the expression of glutathione-S-transferases in the liver of the intact rat and in hepatocytes in primary culture

Hepatology

Volumn 23, Issue 4, 1996, Pages 881-887

  Langouët, Sophie ^a   Morel, Fabrice ^a   Meyer, David J ^b   Fardel, Olivier ^a   Corcos, Laurent ^a   Ketterer, Brian ^b   Guillouzo, Andre ^a  

^a PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DITHIOLE 3 THIONE DERIVATIVE; 3 METHYLCHOLANTHRENE; AFLATOXIN B1; DACTINOMYCIN; ENZYME INDUCING AGENT; GLUTATHIONE TRANSFERASE; MESSENGER RNA; OLTIPRAZ; PHENOBARBITAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME SUBUNIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER CARCINOGENESIS; LIVER CELL CULTURE; LIVER CYTOSOL; LIVER TOXICITY; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT; XENOBIOTIC METABOLISM;

ANIMALS; CELLS, CULTURED; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE TRANSFERASE; LIVER; MALE; METHYLCHOLANTHRENE; PHENOBARBITAL; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 85045533706     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510230432     Document Type: Article

References (9)

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3. Harris JM, Meyer DJ, Coles B, Ketterer B. A novel glutathione transferase (13-13) isolated from the matrix of rat liver mitochondria having structural similarity to class theta enzymes. Biochem J 1991;278:137-141.
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5. 1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry. Cancer Res 1991;51:5501-5506.
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8. Morel F, Fardel O, Meyer DJ, Langouët S, Gilmore KS, Meunier B, Tu CPD, Kensler TW, Ketterer B, Guillouzo A. Preferential increase of glutathione S-transferase class α transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones. Cancer Res 1993;53:231-234.
9. Igarashi T, Irokawa N, Ono S, Ohmori S, Ueno K, Kitagawa H, Satoh T. Differences in the effects of phenobarbital and 3-methylcholanthrene treatment on subunit composition of hepatic glutathione S-transferase in male and female rats. Xenobiotica 1987;17:127-137.